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Synthesis and antibacterial activity of novel arylbis(indol-3-yl)methane derivatives

The Journal of Antibiotics volume 74, pages 219–224 (2021)Cite this article

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Abstract

A series of new compounds—arylbis(indol-3-yl)methylium derivatives—were synthesized and their antimicrobial activity was evaluated. All the compounds turned out to be highly active, with MIC depending on their structure and the length of N-alkyl residues. The parent triarylmethane compounds possess weaker activity.

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Fig. 1
Scheme 1
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Scheme 2

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Acknowledgements

The research was supported by a grant from the Russian Science Foundation (project no. 16-15-10300P).

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Authors and Affiliations

  1. Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow, 119021, Russia

    Alexey A. Panov, Sergey N. Lavrenov, Elena P. Mirchink, Elena B. Isakova, Alexander M. Korolev & Alexey S. Trenin

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  1. Alexey A. Panov
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  2. Sergey N. Lavrenov
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  3. Elena P. Mirchink
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  4. Elena B. Isakova
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  5. Alexander M. Korolev
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  6. Alexey S. Trenin
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Correspondence to Alexey A. Panov.

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Panov, A.A., Lavrenov, S.N., Mirchink, E.P. et al. Synthesis and antibacterial activity of novel arylbis(indol-3-yl)methane derivatives. J Antibiot 74, 219–224 (2021). https://doi.org/10.1038/s41429-020-00389-9

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