Abstract
The coculture of marine red algal-derived endophytic fungi Aspergillus terreus EN-539 and Paecilomyces lilacinus EN-531 induced the production of a new terrein derivative, namely asperterrein (1) and a known dihydroterrein (2), which were not detected in the axenic cultures of both strains. The production of the known secondary metabolites terrein (3), butyrolactone I (4), and dankasterone (6), derived from A. terreus EN-539, were depressed significantly in the coculture. Compounds 1–3 exhibited inhibitory activity against Alternaria brassicae, Escherichia coli, Physalospora piricola, and Staphylococcus aureus with MIC values ranging from 4 to 64 μg ml−1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tan RX, Zou WX. Endophytes: a rich source of functional metabolites. Nat Prod Rep. 2001;18:448–59.
Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016;79:629–61.
Pettit RK. Mixed fermentation for natural product drug discovery. Appl Microbiol Biot. 2009;83:19–25.
Strobel GA. Endophytes as sources of bioactive products. Microbes Infect. 2003;5:535–44.
Bertrand S, et al. Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery. Biotechnol Adv. 2014;32:1180–204.
Meng LH, et al. Citrifelins A and B, citrinin adducts with a tetracyclic framework from cocultures of marine-derived isolates of Penicillium citrinum and Beauveria feline. J Nat Prod. 2015;78:2301–5.
Li XD, et al. Aspewentins D–H, 20-nor-isopimarane derivatives from the deep sea sediment-derived fungus Aspergillus wentii SD-310. J Nat Prod. 2016;79:1347–53.
Li HL, Li XM, Liu H, Meng LH, Wang BG. Two new diphenylketones and a new xanthone from Talaromyces islandicus EN-501, an endophytic fungus derived from the marine red alga Laurencia okamurai. Mar Drugs. 2016;14:223–30.
Li HL, et al. Antioxidant hydroanthraquinones from the marine algal-derived endophytic fungus Talaromyces islandicus EN-501. J Nat Prod. 2017;80:162–68.
Shipe WD, Sorensen EJ. Convergent, enantioselective syntheses of guanacastepenes A and E featuring a selective cyclobutane fragmentation. J Am Chem Soc. 2006;128:7025–35.
Hosoe T, et al. Inhibitory effects of dihydroterrein and terrain isolated from Aspergillus novofumigatus on platelet aggregation. Mycotoxins. 2009;59:75–82.
Malmstrøm J, et al. Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor. J Nat Prod. 2002;65:364–7.
Arakawa M, Someno T, Kawada M, Ikeda D. A new terrein glucoside, a novel inhibitor of angiogenin secretion in tumor angiogenesis. J Antibiot. 2008;61:442–8.
Wang Y, Zheng JK, Liu PP, Wang W, Zhu WM. Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium. Mar Drugs. 2011;9:1368–78.
Rao KV, et al. Butyrolactones from Aspergillus terreus. Chem Pharm Bull. 2000;48:559–62.
Amagata T, Doi M, Tohgo M, Minoura K, Numata A. Dankasterone, a new class of cytotoxic steroid produced by a Gymnascella species from a marine sponge. Chem Commun. 1999;14:1321–2.
Acknowledgements
This work was financially supported by the National Natural Science Foundation of China (31330009). H-LL thanks the Natural Science Foundation of Shandong Province (ZR2018BD031) and China Postdoctoral Science Foundation (2018M632732) for the support. B-GW appreciates the support of Taishan Scholar Program from Shandong Province.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
About this article
Cite this article
Li, HL., Li, XM., Yang, SQ. et al. Induced terreins production from marine red algal-derived endophytic fungus Aspergillus terreus EN-539 co-cultured with symbiotic fungus Paecilomyces lilacinus EN-531. J Antibiot 73, 108–111 (2020). https://doi.org/10.1038/s41429-019-0242-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41429-019-0242-4
This article is cited by
-
A new steroid with potent antimicrobial activities and two new polyketides from Penicillium variabile EN-394, a fungus obtained from the marine red alga Rhodomela confervoides
The Journal of Antibiotics (2024)
-
Natural products from marine fungi as a source against agricultural pathogenic fungi
Applied Microbiology and Biotechnology (2023)
-
Aspergillus co-cultures: A recent insight into their secondary metabolites and microbial interactions
Archives of Pharmacal Research (2023)
-
Co-culture: stimulate the metabolic potential and explore the molecular diversity of natural products from microorganisms
Marine Life Science & Technology (2021)
-
Antimicrobial compounds from marine fungi
Phytochemistry Reviews (2021)