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Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216

The Journal of Antibioticsvolume 71pages606608 (2018) | Download Citation

Abstract

Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.

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Acknowledgements

We are grateful to Dr Kenichiro Nagai and Ms Noriko Sato, School of Pharmacy, Kitasato University for measurements of MS and NMR data.

Funding

This study was supported by funding from the Institute for Fermentation, Osaka (IFO), Japan.

Author information

Affiliations

  1. Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

    • Tōru Kimura
    • , Yuki Inahashi
    • , Hirotaka Matsuo
    • , Takuya Suga
    • , Masato Iwatsuki
    • , Kazuro Shiomi
    •  & Takuji Nakashima
  2. Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan

    • Yuki Inahashi
    • , Hirotaka Matsuo
    • , Takuya Suga
    • , Masato Iwatsuki
    • , Kazuro Shiomi
    • , Yōko Takahashi
    • , Satoshi Ōmura
    •  & Takuji Nakashima

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Takuji Nakashima.

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DOI

https://doi.org/10.1038/s41429-018-0038-y