Brief Communication

Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216

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Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.

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  1. 1.

    Nakashima T, et al. Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216. J Antibiot. 2014;67:253–60.

  2. 2.

    Nakashima T, Kamiya Y, Iwatsuki M, Takahashi Y, Ōmura S. Mangromicins, six new anti-oxidative agents isolated from a culture broth of the actinomycete, Lechevalieria aerocolonigenes K10-0216. J Antibiot. 2014;67:533–9.

  3. 3.

    Nakashima T, et al. Mangromicin C, a new analog of mangromicin. J Antibiot. 2015;68:220–2.

  4. 4.

    Nakashima T, et al. New steroidal compounds from an actinomycete strain, Lechevalieria aerocolonigenes K10-0216. J Antibiot. 2015;68:348–50.

  5. 5.

    Takada H, et al. Total synthesis and determination of the absolute configuration of naturally occurring mangromicin A, with potent antitrypanosomal activity. Org Lett. 2017;19:230–3.

  6. 6.

    Nakashima T, Takahashi Y, Ōmura S. Search for new compounds from Kitasato microbial library by physicochemical screening. Biochem Pharmacol. 2017;15:42–55.

  7. 7.

    Tsurumi Y, et al. WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. J Antibiot. 1994;48:1066–72.

  8. 8.

    Goshima S, et al. Report from the committee on antimicrobial susceptibility testing, Japanese Society of Chemotherapy. Chemotherapy. 1990;38:102–5.

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We are grateful to Dr Kenichiro Nagai and Ms Noriko Sato, School of Pharmacy, Kitasato University for measurements of MS and NMR data.


This study was supported by funding from the Institute for Fermentation, Osaka (IFO), Japan.

Author information


  1. Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan

    • Tōru Kimura
    • , Yuki Inahashi
    • , Hirotaka Matsuo
    • , Takuya Suga
    • , Masato Iwatsuki
    • , Kazuro Shiomi
    •  & Takuji Nakashima
  2. Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan

    • Yuki Inahashi
    • , Hirotaka Matsuo
    • , Takuya Suga
    • , Masato Iwatsuki
    • , Kazuro Shiomi
    • , Yōko Takahashi
    • , Satoshi Ōmura
    •  & Takuji Nakashima


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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Takuji Nakashima.

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