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New phenolic bisabolane sesquiterpenoid derivatives with cytotoxicity from Aspergillus tennesseensis

The Journal of Antibioticsvolume 71pages538542 (2018) | Download Citation

Abstract

Three new bisabolane sesquiterpenoid esters, aspertenols A–B (13), and six known compounds (49) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were elucidated by extensive spectroscopic analysis. The cytotoxicities of 19 against A549, K562, and ASPC cell lines were tested by using the CCK8 method. Compounds 1, 3, 4, 6, 7, and 9 showed inhibition on K562 cell line with IC50 values in the range from 16.6 to 72.7 μM. Compounds 1, 4, and 9 showed moderate inhibitory activity against A549 with IC50 of 43.5, 70.2, and 61.1 μM, respectively.

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Acknowledgements

This work was supported in part by the National Natural Science Foundation of China (81673334).

Author information

Author notes

  1. Li Liu and Ruixing Liu contributed equally to this work

Affiliations

  1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, China

    • Li Liu
    • , Ruixing Liu
    • , Buddha Bahadur Basnet
    • , Li Bao
    • , Junjie Han
    • , Long Wang
    •  & Hongwei Liu
  2. Savaid Medicine School, University of Chinese Academy of Sciences, Beijing, 100049, China

    • Li Liu
    • , Ruixing Liu
    • , Li Bao
    • , Junjie Han
    •  & Hongwei Liu
  3. International College, University of Chinese Academy of Sciences, Beijing, 100049, China

    • Buddha Bahadur Basnet

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding authors

Correspondence to Long Wang or Hongwei Liu.

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DOI

https://doi.org/10.1038/s41429-018-0025-3

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