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Characteristics of ethylenediamine tetra-acetic acid treatment on iron(III)-induced modified catechol chitosan hydrogels under different pH conditions

Polymer Journal volume 55, pages 1335–1345 (2023)Cite this article

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Abstract

Modified catechol chitosan was synthesized to examine the intricate connections between Fe(III) and catechol under different pH conditions. The conjugation of the catechol moieties, which determines the structure of the hydrogel, was evaluated by nuclear magnetic resonance spectroscopy and ultraviolet‒visible spectroscopy. The gel formation was well maintained by the dual cross-linking networks of the electrostatic interactions between catechol chitosan solution (CCS) and Fe3+ along with the covalent catechol-coupling-based coordinate bonds. Three pH conditions of 3, 5, and 7 were applied for ethylenediamine tetra-acetic acid (EDTA) treatment as a triggering factor in modifying the uniform hydrogel structure. The hydrogels demonstrated enhanced mechanical strength and cohesiveness at a pH of 5, and rheology analysis was used to determine the storage and loss moduli. Several analysis and characterization techniques were utilized to describe the cross-linking components and confirm the physical properties of the chitosan backbone polymer chain in the modified iron-induced hydrogel frameworks before and after EDTA treatment.

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Acknowledgements

This research was supported by the Basic Science Research Program administered through the National Research Foundation of Korea (NRF) and funded by the Ministry of Education (2020R1A6A1A06046728, 2022R1A2C1010580, and 2022R1A6C101A779-23).

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Authors and Affiliations

  1. Department of Chemistry and Research Institute for Convergence of Basic Science, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea

    Ngoc Quang Nguyen, Jungju Ryu & Daewon Sohn

  2. Department of Chemistry, Shivaji University, Kolhapur, 416004, MS, India

    Govind Kolekar

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  1. Ngoc Quang Nguyen
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NQN: Conceptualization, Investigation, Formal analysis, Writing-original draft. JR: Writing-review and editing. GK: Writing-review and editing. DS: Supervision, Writing-review and editing.

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Correspondence to Daewon Sohn.

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Nguyen, N.Q., Ryu, J., Kolekar, G. et al. Characteristics of ethylenediamine tetra-acetic acid treatment on iron(III)-induced modified catechol chitosan hydrogels under different pH conditions. Polym J 55, 1335–1345 (2023). https://doi.org/10.1038/s41428-023-00827-z

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