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The Passerini three-component reaction of aldehyde end-functionalized polymers via RAFT polymerization using chain transfer agents featuring aldehyde

Abstract

In this study, a novel pyrazole–carbodithioate-based chain transfer agent (CTA) featuring an aldehyde group (CTA-CHO) was designed and synthesized for RAFT polymerization. The obtained CTA-CHO was employed for the RAFT polymerization of styrene to afford well-defined polystyrenes bearing an aldehyde at their chain ends with low Ð values (~1.1). In addition, the reactivity of the aldehyde moiety at the end of the chain was precisely evaluated, while the Passerini three-component reaction was successfully performed on the aldehyde group.

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Acknowledgements

RK gratefully acknowledges the Leading Initiative for Excellent Young Researchers (LEADER) and a Grant-in-Aid for Scientific Research (C) (no. 19K05578) for financial support.

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Correspondence to Ryohei Kakuchi.

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Kakuchi, R., Okura, Y. The Passerini three-component reaction of aldehyde end-functionalized polymers via RAFT polymerization using chain transfer agents featuring aldehyde. Polym J 52, 1057–1066 (2020). https://doi.org/10.1038/s41428-020-0368-z

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