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Tissue-resident macrophages exacerbate lung injury after remote sterile damage

Cellular & Molecular Immunology volume 21, pages 332–348 (2024)Cite this article

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A Correction to this article was published on 01 March 2024

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Abstract

Remote organ injury, which is a common secondary complication of sterile tissue damage, is a major cause of poor prognosis and is difficult to manage. Here, we report the critical role of tissue-resident macrophages in lung injury after trauma or stroke through the inflammatory response. We found that depleting tissue-resident macrophages rather than disrupting the recruitment of monocyte-derived macrophages attenuated lung injury after trauma or stroke. Our findings revealed that the release of circulating alarmins from sites of distant sterile tissue damage triggered an inflammatory response in lung-resident macrophages by binding to receptor for advanced glycation end products (RAGE) on the membrane, which activated epidermal growth factor receptor (EGFR). Mechanistically, ligand-activated RAGE triggered EGFR activation through an interaction, leading to Rab5-mediated RAGE internalization and EGFR phosphorylation, which subsequently recruited and activated P38; this, in turn, promoted RAGE translation and trafficking to the plasma membrane to increase the cellular response to RAGE ligands, consequently exacerbating inflammation. Our study also showed that the loss of RAGE or EGFR expression by adoptive transfer of macrophages, blocking the function of RAGE with a neutralizing antibody, or pharmacological inhibition of EGFR activation in macrophages could protect against trauma- or stroke-induced remote lung injury. Therefore, our study revealed that targeting the RAGE-EGFR signaling pathway in tissue-resident macrophages is a potential therapeutic approach for treating secondary complications of sterile damage.

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Acknowledgements

We thank Xuegang Sun, Zaisheng Qin, Yuanliang Liu and Zhiyun Zeng (Southern Medical University) for their technical assistance. This work was supported by the National Key R&D Program of China (2021YFC2701700 to JT and XYH), the National Natural Science Foundation of China (81671957 and 81873951 to JT, 82200093 to HHZ), the Guangdong Natural Science Foundation (2023A1515012498 to HHZ), and the Medical Scientific Research Foundation of Guangdong Province (A2022256 to HHZ).

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  1. These authors contributed equally: Hanhui Zhong, Jingjing Ji, Jinling Zhuang.

Authors and Affiliations

  1. The Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China

    Hanhui Zhong, Jinling Zhuang, Ziying Xiong, Pengyun Xie, Xiaolei Liu, Wangli Tian & Jing Tang

  2. The Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou, China

    Jingjing Ji

  3. The Department of Respiratory Medicine, Guangdong Provincial Hospital of Integrated Chinese and Western Medicine, Foshan, China

    Jundi Zheng

  4. Pediatric Intensive Care Unit, Senior Department of Pediatrics, the Seventh Medical Center of PLA General Hospital, Beijing, China

    Xiaoyang Hong

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Contributions

JT and XYH conceived and supervised the study. HHZ and JJJ designed and performed the experiments and analyzed the data with JLZ, who also prepared the figures. ZYX, XLL, PYX, WLT, and JDZ performed the experiments. JT revised the manuscript. All the authors performed critical reviews of the manuscript. HHZ, XYH, and JT wrote the manuscript.

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Correspondence to Xiaoyang Hong or Jing Tang.

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Additional information

The original online version of this article was revised: The wrong Supplementary file was originally published with this article; it has now been replaced with the correct file. In detail, the western blotting of t-EGFR in Supplementary Figure 14a was mistakenly presented with an incorrect image. Supplementary Figure 14a has been corrected. The corrected Supplementary Figure 14 is shown below. The error and correction did not impact the conclusion of the paper. The authors regret the error. The original article has been corrected.

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Zhong, H., Ji, J., Zhuang, J. et al. Tissue-resident macrophages exacerbate lung injury after remote sterile damage. Cell Mol Immunol 21, 332–348 (2024). https://doi.org/10.1038/s41423-024-01125-1

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