Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Vascular macrophages sense octanal and drive athero-inflammation

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1

References

  1. Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, et al. Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Science. 2022;375:214–21.

    Article  CAS  Google Scholar 

  2. Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol. 2009;183:787–91.

    Article  CAS  Google Scholar 

  3. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. CANTOS Trial Group. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377:1119–31.

    Article  CAS  Google Scholar 

  4. McArdle S, Buscher K, Ghosheh Y, Pramod AB, Miller J, Winkels H, et al. Migratory and dancing macrophage subsets in atherosclerotic lesions. Circ Res. 2019;125:1038–51.

    Article  CAS  Google Scholar 

  5. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010;464:1357–61.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (Nos. 81970373, 31770977 and 81920108003), the Postdoctoral Science Foundation of China and Shandong Province (No. 2018M630789 and No. 201901009), the Shandong Provincial Natural Science Foundation (ZR2020YQ53), the National Key Research and Development Program of China (2021YFF0501403), the Taishan Scholars Program of Shandong Province (ZM and ZC), and the Fundamental Research Funds for the Central Universities (No. 2018JC001).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Meng Zhang or Cheng Zhang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Qiao, L., Zhang, M. & Zhang, C. Vascular macrophages sense octanal and drive athero-inflammation. Cell Mol Immunol 19, 1077–1078 (2022). https://doi.org/10.1038/s41423-022-00896-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41423-022-00896-9

Search

Quick links