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Analysis of uterine CD49a+ NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion

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Fig. 1


  1. 1.

    Moffett, A. & Shreeve, N. First do no harm: uterine natural killer (NK) cells in assisted reproduction. Hum. Reprod. 30, 1519–1525 (2015).

    CAS  Article  Google Scholar 

  2. 2.

    Sacks, G. Enough! Stop the arguments and get on with the science of natural killer cell testing. Hum. Reprod. 30, 1526–1531 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Rai, R., Sacks, G. & Trew, G. Natural killer cells and reproductive failure-theory, practice and prejudice. Hum. Reprod. 20, 1123–1126 (2005).

    Article  Google Scholar 

  4. 4.

    Sacks, G. et al. Detailed analysis of peripheral blood natural killer cells in women with repeated IVF failure. Am. J. Reprod. Immunol. 67, 434–442 (2012).

    CAS  Article  Google Scholar 

  5. 5.

    van der Molen, R. G. et al. Menstrual blood closely resembles the uterine immune micro-environment and is clearly distinct from peripheral blood. Hum. Reprod. 29, 303–314 (2014).

    Article  Google Scholar 

  6. 6.

    Wang, W. et al. Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle. Nat. Med. 26, 1644–1653 (2020).

    CAS  Article  Google Scholar 

  7. 7.

    Strunz, B. et al. Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy. Sci. Immunol. 6, (2021).

  8. 8.

    Fu, B. Q. et al. Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity 47, 1100 (2017).

    CAS  Article  Google Scholar 

  9. 9.

    Guo, C. et al. Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss. Cell Discov. 7, 1 (2021).

    CAS  Article  Google Scholar 

  10. 10.

    Zhou, Y. et al. PBX1 expression in uterine natural killer cells drives fetal growth. Sci. Transl. Med. 12, (2020).

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This work was supported by the National Key Research & Developmental Program of China (no. 2018YFC1003900 to H.W.) and the National Natural Science Foundation of China (81930037 to H.W.; 31870914, 81922028 to B.F.), and Youth Innovation Promotion Association of Chinese Academy of Sciences (Grant 2019442 to B.F.).

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X.T. collected tissue samples and information from patients and assisted with data interpretation. M.G. and X.D. performed the experiments and analyzed and interpreted the data. F.L. and L.W. helped to collect tissue samples and information from patients. H.W. provided strategic planning, conceived the project, and interpreted some data. B.F. supervised the project, designed and provided crucial ideas, and assisted with data interpretation. B.F. wrote the manuscript with M.G. and H.W.

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Correspondence to Haiming Wei or Binqing Fu.

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The authors declare no competing interests.

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Tong, X., Gao, M., Du, X. et al. Analysis of uterine CD49a+ NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion. Cell Mol Immunol (2021).

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