This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Choy, E. H. et al. Translating IL-6 biology into effective treatments. Nat. Rev. Rheumatol. 16, 335–345 (2020).
Bijlsma, J. W. J. et al. Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial. Lancet 388, 343–355 (2016).
Yang, J. et al. Chikusetsusaponin IVa butyl ester (CS-IVa-Be), a novel IL6R antagonist, inhibits IL6/STAT3 signaling pathway and induces cancer cell apoptosis. Mol. Cancer Ther. 15, 1190–1200 (2016).
Finzel, S. et al. Comparison of the effects of tocilizumab monotherapy and adalimumab in combination with methotrexate on bone erosion repair in rheumatoid arthritis. Ann. Rheum. Dis. 78, 1186–1191 (2019).
Heo, Y. J. et al. IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett. 127, 150–156 (2010).
Samson, M. et al. Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis Rheum. 64, 2499–2503 (2012).
Fujimoto, M. et al. Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 58, 3710–3719 (2008).
Acknowledgements
The authors would like to thank Professor Liwei Lu in Hong Kong University for assistance for CIA model establishment and manuscript revision, and Professor You Yang at East China University of Science and Technology for synthesizing CS. This work was supported by a grant from the National Natural Science Foundation of China (No. 81773973).
Author information
Authors and Affiliations
Contributions
Study conception and design: P.C., J.Y., C.H. Acquisition of data: J.Y., C.Z., Y.L., D.H. Analysis and interpretation of data: J.Y., Y.L., D.H. Paper writing: J.Y. Manuscript editing and revision: P.C., X.S., X.C., J.C.
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Supplementary information
Rights and permissions
About this article
Cite this article
Yang, J., Ling, Y., Hua, D. et al. IL-6R blockade by chikusetsusaponin IVa butyl ester inhibits Th17 cell differentiation and ameliorates collagen-induced arthritis. Cell Mol Immunol 18, 1584–1586 (2021). https://doi.org/10.1038/s41423-021-00651-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41423-021-00651-6