Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Periarteriolar stroma cells guide T cells from the red to the white pulp in the spleen

Cellular & Molecular Immunology volume 17, pages 1019–1021 (2020)Cite this article

Subjects

Abstract

While both the spleen and lymph nodes are called secondary lymphoid tissues, how lymphocytes enter these tissues are quite different from each other. This is because the architecture of the two types of organs and the mode of lymphocyte migration into these organs are quite distinct. In the spleen, T cells are passively released in the blood flow from the arterioles in the red pulp and marginal zone area. In contrast, T cells in the blood are actively captured on high endothelial venules in lymph nodes by the coordinated actions of CCR7 and several adhesion molecules. A recent finding indicates that T cells, released in the red pulp and marginal zone areas, actively find their way to the white zone by utilizing the migration track created by periarteriolar stromal cells. This finding adds one more piece to our understanding of lymphocyte migration for effective adaptive immune responses in the spleen.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

References

  1. Chauveau, A. et al. Visualization of T cell migration in the spleen reveals a network of perivascular pathways that guide entry into T zones. Immunity 52, 794–807 (2020).

    Article  CAS  Google Scholar 

  2. Mebius, R. E. & Kraal, G. Structure and function of the spleen. Nat. Rev. Immunol. 5, 606–616 (2005).

    Article  CAS  Google Scholar 

  3. Johns, J. L. & Christopher, M. M. Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals. Vet. Pathol. 49, 508–523 (2012).

    Article  CAS  Google Scholar 

  4. Kim, C. H. The greater chemotactic network for lymphocyte trafficking: chemokines and beyond. Curr. Opin. Hematol. 12, 298–304 (2005).

    Article  CAS  Google Scholar 

  5. Allen, C. D. et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat. Immunol. 5, 943–952 (2004).

    Article  CAS  Google Scholar 

  6. Hargreaves, D. C. et al. A coordinated change in chemokine responsiveness guides plasma cell movements. J. Exp. Med. 194, 45–56 (2001).

    Article  CAS  Google Scholar 

  7. Gunn, M. D. et al. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl Acad. Sci. USA. 95, 258–263 (1998).

    Article  CAS  Google Scholar 

  8. Butcher, E. C., Williams, M., Youngman, K., Rott, L. & Briskin, M. Lymphocyte trafficking and regional immunity. Adv. Immunol. 72, 209–253 (1999).

    Article  CAS  Google Scholar 

  9. Worbs, T., Mempel, T. R., Bolter, J., von Andrian, U. H. & Forster, R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med. 204, 489–495 (2007).

    Article  CAS  Google Scholar 

  10. Nieuwenhuis, P. & Ford, W. L. Comparative migration of B- and T-Lymphocytes in the rat spleen and lymph nodes. Cell Immunol. 23, 254–267 (1976).

    Article  CAS  Google Scholar 

  11. Kim, C. H. et al. Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Investig. 108, 1331–1339 (2001).

    Article  CAS  Google Scholar 

  12. Bankovich, A. J., Shiow, L. R. & Cyster, J. G. CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. J. Biol. Chem. 285, 22328–22337 (2010).

    Article  CAS  Google Scholar 

  13. Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355–360 (2004).

    Article  CAS  Google Scholar 

  14. Lortan, J. E., Roobottom, C. A., Oldfield, S. & MacLennan, I. C. Newly produced virgin B cells migrate to secondary lymphoid organs but their capacity to enter follicles is restricted. Eur. J. Immunol. 17, 1311–1316 (1987).

    Article  CAS  Google Scholar 

  15. Ansel, K. M. et al. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406, 309–314 (2000).

    Article  CAS  Google Scholar 

  16. Kim, C. H. et al. Unique gene expression program of human germinal center T helper cells. Blood 104, 1952–1960 (2004).

    Article  CAS  Google Scholar 

  17. Cyster, J. G. et al. Follicular stromal cells and lymphocyte homing to follicles. Immunol. Rev. 176, 181–193 (2000).

    Article  CAS  Google Scholar 

  18. Yi, T. et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity 37, 535–548 (2012).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

C.H.K. is the Judy and Kenneth Betz Endowed Professor in the Mary H Weiser Food Allergy Center. He was supported in part by grants from the NIH (R01AI121302 and R21AI14889801).

Author information

Authors and Affiliations

  1. Laboratory of Immunology and Hematopoiesis, Mary H. Weiser Food Allergy Center, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Chang H. Kim & Qingyang Liu

  2. Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Chang H. Kim & Qingyang Liu

  3. Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Chang H. Kim & Qingyang Liu

Authors
  1. Chang H. Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qingyang Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chang H. Kim.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, C.H., Liu, Q. Periarteriolar stroma cells guide T cells from the red to the white pulp in the spleen. Cell Mol Immunol 17, 1019–1021 (2020). https://doi.org/10.1038/s41423-020-0506-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41423-020-0506-8

Search

Advanced search

Quick links