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Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation

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Acknowledgements

We thank P. Pelegrin (Instituto Murciano de Investigación Biosanitaria) and E. Latz (Institute of Innate Immunity) for the immortalized ASC-mCherry macrophages. We acknowledge Paola Brun, Ignazio Castagliuolo, Bianca Cali, Sara Zumerle, and Denis Martin-Valet for helpful discussion and Luisa Bin and Alberto Zecca for their contribution in performing experiments. The study was supported by ERC Steps 322823 to A.V. and IRP-PENTA Grant 18/07-1 to M.C.

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A.V. and M.C. designed the study, wrote the manuscript, and provided funds; R.S.R., F.M., A.A., F.V., and R.A. performed most of the experiments and the subsequent data analyses and prepared the figures; M.P.C.G. helped in performing experiments; R.L. performed in vivo experiments in the murine endotoxemia model; A.C. performed mass spectrometric analyses.

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Correspondence to Antonella Viola or Marcella Canton.

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The authors declare no competing interests.

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Sánchez-Rodríguez, R., Munari, F., Angioni, R. et al. Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation. Cell Mol Immunol 18, 1311–1313 (2021). https://doi.org/10.1038/s41423-020-0441-8

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