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Steinman, R. M. & Cohn, Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med. 137, 1142–1162 (1973).
del Rio, M. L., Bernhardt, G., Rodriguez-Barbosa, J. I. & Forster, R. Development and functional specialization of CD103+ dendritic cells. Immunol. Rev. 234, 268–281 (2010).
Kessel, C. H. G. & Lambrecht, B. N. Division of labor between dendritic cell subsets of the lung. Mucosal Immunol. 1, 442–450 (2008).
Shekhar, S., Peng, Y., Wang, S. & Yang, X. CD103+ lung dendritic cells (LDCs) induce stronger Th1/Th17 immunity to a bacterial lung infection than CD11b(hi) LDCs. Cell Mol. Immunol. 15, 377–87. (2018).
Hackstein, H. et al. Modulation of respiratory dendritic cells during Klebsiella pneumonia infection. Resp. Res. 14, 91 (2013).
Helft, J. et al. Cross-presenting CD103(+) dendritic cells are protected from influenza virus infection. J. Clin. Invest. 122, 4037–4047 (2012).
Gutierrez-Martinez, E. et al. Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets. Front. Immunol. 6, 363 (2015).
O’Keeffe, M., Mok, W. H. & Radford, K. J. Human dendritic cell subsets and function in health and disease. Cell. Mol. Life Sci. 72, 4309–4325 (2015).
GeurtsvanKessel, C. H. et al. Clearance of influenza virus from the lung depends on migratory langerin(+)CD11b(−) but not plasmacytoid dendritic cells. J. Exp. Med. 205, 1621–34. (2008).
Desai, P., Tahiliani, V., Abboud, G., Stanfield, J. & Salek-Ardakani, S. Batf3-dependent dendritic cells promote optimal CD8 T cell responses against respiratory poxvirus infection. J. Virol. 92, e00495–18 (2018).
Ho, A. W. et al. Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells. J. Immunol. 187, 6011–6021 (2011).
Ng, S. L., Teo, Y. J., Setiagani, Y. A., Karjalainen, K. & Ruedl, C. Type 1 conventional CD103(+) dendritic cells control effector CD8(+) T cell migration, survival, and memory responses during influenza infection. Front. Immunol. 9, 3043 (2018).
Hemann, E. A. et al. Interferon-lambda modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus. Nat. Immunol. 20, 1035–45. (2019).
Koh, V. H. et al. Role and contribution of pulmonary CD103(+) dendritic cells in the adaptive immune response to Mycobacterium tuberculosis. Tuberculosis (Edinb.) 102, 34–46 (2017).
Zelante, T. et al. CD103(+) dendritic cells control Th17 cell function in the lung. Cell Rep. 12, 1789–1801 (2015).
Minoda, Y. et al. Human CD141(+) dendritic cell and CD1c(+) dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo. Front Immunol. 8, 1419 (2017).
The authors declare no competing interests.
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Shekhar, S., Yang, X. Pulmonary CD103+ dendritic cells: key regulators of immunity against infection. Cell Mol Immunol (2020). https://doi.org/10.1038/s41423-020-0397-8