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Towards the understanding of the genetics of somatic mutations

British Journal of Cancer volume 125, pages 627–628 (2021)Cite this article

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Summary

A recent study from Sun et al. reveals a polygenic architecture for pan-cancer tumour mutational burden (TMB) and shows the identification of genes underpinning the associations between germline genetic variants and TMB in specific cancer types. Here we discuss the main findings of the Sun et al. study and the implications for further studies.

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Authors and Affiliations

  1. Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, China

    Xiwei Sun

  2. School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China

    Xiwei Sun & Jian Yang

  3. Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China

    Jian Yang

Authors
  1. Xiwei Sun
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  2. Jian Yang
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X.S. and J.Y. wrote the manuscript.

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Correspondence to Jian Yang.

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The authors declare no competing interests.

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This work is partly supported by the Westlake Education Foundation.

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Sun, X., Yang, J. Towards the understanding of the genetics of somatic mutations. Br J Cancer 125, 627–628 (2021). https://doi.org/10.1038/s41416-021-01369-y

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  • DOI: https://doi.org/10.1038/s41416-021-01369-y

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