A recent study from Sun et al. reveals a polygenic architecture for pan-cancer tumour mutational burden (TMB) and shows the identification of genes underpinning the associations between germline genetic variants and TMB in specific cancer types. Here we discuss the main findings of the Sun et al. study and the implications for further studies.
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The authors declare no competing interests.
This work is partly supported by the Westlake Education Foundation.
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Sun, X., Yang, J. Towards the understanding of the genetics of somatic mutations. Br J Cancer 125, 627–628 (2021). https://doi.org/10.1038/s41416-021-01369-y