Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this ‘normalises’ CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.
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C.J. Hanley and G.J. Thomas are co-inventors on patent WO2019086579.
The work described in the commentary was funded through Cancer Research UK (grant nos. A203904, A20256 and A27989) and Medical Research Council UK (grant no. MR/P013414/1).
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Hanley, C.J., Thomas, G.J. T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting. Br J Cancer (2020). https://doi.org/10.1038/s41416-020-1020-6