T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting

Summary

Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this ‘normalises’ CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.

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Fig. 1: Schematic showing possible strategies for targeting CAFs and overcoming CAF-mediated T-cell exclusion from tumours.

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G.T. conceived the paper and C.H contributed to its writing. Both approved the final version.

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Correspondence to Gareth J. Thomas.

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Competing interests

C.J. Hanley and G.J. Thomas are co-inventors on patent WO2019086579.

Funding information

The work described in the commentary was funded through Cancer Research UK (grant nos. A203904, A20256 and A27989) and Medical Research Council UK (grant no. MR/P013414/1).

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Hanley, C.J., Thomas, G.J. T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting. Br J Cancer (2020). https://doi.org/10.1038/s41416-020-1020-6

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