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Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper


Immunotherapy with checkpoint inhibitors against programmed cell death receptor (PD-1) and programmed cell death ligand (PD-L1) has been implemented in the treatment pathway of patients with non-small cell lung cancer (NSCLC) from locally advanced disease to the metastatic setting. This approach has resulted in improved survival and a more favourable toxicity profile when compared with chemotherapy. Following the successful introduction of single-agent immunotherapy, current clinical trials are focusing on combination treatments with chemotherapy or radiotherapy or even other immunotherapeutic agents. However, most of the data available from these trials are derived from, and therefore might be more applicable to younger and fitter patients rather than older and often frail lung cancer real-world patients. This article provides a detailed review of these immunotherapy agents with a focus on the data available regarding older NSCLC patients and makes recommendations to fill evidence gaps in this patient population.


More than half of all patients with non-small cell lung cancer (NSCLC) are aged above 70 years, and almost 10% are 80 years or older.1 The multi-organ age-related decline can alter drug pharmacokinetics and increase the risk of complications of locoregional and systemic treatments.2,3 This risk is also influenced by the increasing burden of comorbidities and polypharmacy, which increase the risk of adverse events and also impact survival.4,5 Moreover, quality of life (QoL) and functional endpoints are not well represented in clinical trials and should be considered at least as relevant as overall survival (OS).6,7

Chronological age alone provides relatively little information regarding the tolerance of older patients to cancer treatments. A comprehensive geriatric assessment (CGA), a multidisciplinary diagnostic and treatment process, can fill this knowledge gap and inform treatment decisions by identifying medical, psychosocial and functional limitations of older adults and facilitating a co-ordinated plan to maximise overall health in the context of ageing.8 In older cancer patients, the use of a CGA is associated with a number of benefits:9,10 the prediction of complications and side effects from treatment; estimation of survival; aiding patients, clinicians and family members in treatment decisions; detection of problems neglected by routine history and physical examination in the initial evaluation and new problems during follow-up care; improvement of mental health, well-being and pain control; and highlighting areas for potential intervention. Geriatric assessments have also been found to show prognostic value specifically in NSCLC patients.11,12 Furthermore, models based upon geriatric assessments have been developed to predict the risk of chemotherapy toxicity in older adults and better inform decision making.13,14 However, these assessments can be time-consuming and are not practical for all patients, and screening tools, such as G8, Flemish version of the Triage Risk Screening Tool and Vulnerable Elders Survey-13, have therefore been validated to identify those requiring a CGA.15

Appropriately selected older NSCLC patients have been shown to derive a similar survival benefit compared with their younger counterparts in the curative setting.16,17 Nonetheless, the underrepresentation of older adults in clinical trials defining the current standard of care limits the applicability of such results to the population seen in routine practice.7,18 In the palliative setting where chemotherapy is indicated, the decision-making should not be dictated by age alone.19,20,21 Single-agent chemotherapy can improve OS in older patients without adversely impacting QoL compared with best supportive care alone;22,23,24 data are controversial regarding the benefit of combination chemotherapy in this age group, particularly in those who are more frail.21,25 Tyrosine kinase inhibitors (TKIs) such as those targeting the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK) or ROS-1 are the treatment of choice for oncogene-addicted NSCLC patients, on the basis of the superiority of these agents in survival outcomes and their mild toxicity profile. Although TKIs are often a good match for older patients, these patients constitute a small subset of NSCLC and might still be at a higher risk of toxicity.

Immune checkpoint inhibitors, designed to revitalise antitumour immune responses, have revolutionised the management of a number of malignancies, including NSCLC; this type of immunotherapy also represents a potentially appropriate treatment option for older patients. Below, we outline the mechanism of action of immunotherapy and its adverse events before reviewing the data supporting the use of immunotherapy in patients with NSCLC—alone or in combination—with a particular focus on older patients, in an effort to address the issue of whether age influences the efficacy and toxicity of this approach. We also discuss the potential impact of the ageing process on the immune system and, hence, on the efficacy of immunotherapy.


Mechanism of action of immune checkpoint inhibitors

Strict regulation of the immune system is crucial for allowing the co-ordinated clearance of infected or malignant cells while sparing normal cells. In addition, mechanisms to downregulate the immune response are important to prevent immune over-reactivity once a pathogenic insult has been cleared and in cases where cells different from self are encountered in a physiological setting, such as in gamete formation or in the developing foetus.26

Evading immunosurveillance is one of the hallmarks of cancer—cancer cells hijack the key regulatory mechanisms of the immune system, such as checkpoint pathways, to enable their survival.27 Immune checkpoint pathways operate during homoeostasis to control the duration and extent of immune responses and prevent autoimmunity, but tumour cells have developed the ability to activate inhibitory checkpoints on T cells to avoid being recognised and destroyed. The importance of inhibitory checkpoint signals on T cells in immune evasion led to the development of two classes of inhibitory monoclonal antibody, which are now standard treatment options for a number of malignancies including NSCLC: those that block the interaction between cytotoxic T-lymphocyte associated protein 4 (CTLA4) on the tumour and B7 on the T cell that inhibits T-cell priming activation; and those that block the interaction between programmed death receptor-ligand 1 (PD-L1) on the tumour and programmed death receptor 1 (PD-1) on the T cell that inhibits recognition of the tumour cells by T cell and subsequent tumour cell lysis.28 Ongoing research is investigating the role of multiple targets in thoracic malignancies, including other stimulatory/inhibitory receptors involved in T-cell checkpoints and the use of novel agents in combination with currently licensed agents.26,29

Treatment-related adverse events

Immunotherapy is associated with a unique spectrum of treatment-related adverse events (TRAEs), also known as immune-related adverse events. These include dermatological, gastrointestinal, hepatic, endocrine and other less common inflammatory events arising from general immunologic enhancement.30 Older patients often have an increased risk of TRAEs with cancer treatments in general due to a decreased organ reserve, comorbidities and polypharmacy. In the case of immunotherapy, an aged immune system may, in principle, play an additional important role in determining the risk of TRAEs.


Older age correlates with a decline in organ function,31 including the composition and function of the immune system—its cells, the microenvironment in which they operate and the cytokines modulating their proliferation and activity.32 This decline might, in principle, result in an altered efficacy and safety profile of immunotherapy agents in the older cancer patient.

The remodelling of the immune system associated with the ageing process is called immunosenescence32 and involves a number of changes that can be associated with a decrease in immune surveillance both in the adaptive and innate immune system. In older patients, this reduced surveillance manifests clinically as an increased risk of developing viral and bacterial infections and reactivation of latent infections, such as varicella zoster virus and cytomegalovirus (CMV).33,34 Chemotaxis, phagocytosis and cytotoxicity are impaired, as are the mechanisms of antigen presentation by macrophages and dendritic cells.35 The responsiveness of T cells to pathogens decreases with age and involves a reduced ability to move to lymph nodes, lower proliferation in response to antigens and cytokines and reduced cytokine release. These changes result in the loss of the co-stimulatory protein CD28, particularly in CD8 lymphocytes.36 CD8+CD28 lymphocytes downregulate responses (suppressor effect) via CD4+ cells and dendritic cells, and are often clonally expanded, thereby reducing the numbers of both naïve and central memory T cells. The impact of recurrent infections—in particular, CMV infections—on naïve T cells is deemed to be a key contributor to these changes.37 Interestingly, CD8+CD28 lymphocytes gain other functions, showing increased cytotoxicity mediated by enzymes usually found in natural killer cells.38

Immunotherapy toxicity may occur as a process of autoimmunity. Although higher levels of autoantibodies are seen in older patients, it is still unclear whether this change translates into an increased risk of side effects from immunotherapy agents.39 Additionally, it has been suggested that older adults also have higher levels of myeloid-derived suppressor cells and regulatory T (Treg) cells,40,41 which are key mediators of immune evasion and resistance to checkpoint inhibitors. Older age is associated with higher levels of systemic inflammation, with increased levels of pro-inflammatory cytokines such as interleukin (IL)-6 and acute-phase proteins such as C-reactive protein (CRP), a phenomenon often called ‘inflammaging’.42 While high levels of IL-6 in the tumour microenvironment are associated with resistance to checkpoint inhibitors,26,43 more research is needed on the implications of inflammaging on outcomes of immunotherapy.32 Finally, age also influences the interaction between the microbiome and immune system. Animal models and clinical series suggest that changes in the microbiome influence the efficacy of checkpoint inhibition;44 consequently, the decline in microbiota diversity associated with ageing might negatively influence immune checkpoint inhibitors.45

Single-agent immunotherapy

As immunotherapy with immune checkpoint inhibitors started revolutionising the treatment of NSCLC, the first step was the development of monotherapy agents.


This anti-PD-1 monoclonal antibody was the first checkpoint inhibitor agent to be investigated for the management of patients with advanced NSCLC. The Phase 3, randomised KEYNOTE-010 trial investigated the use of pembrolizumab versus docetaxel in pretreated patients with PD-L1 expression on at least 1% of tumour cells.46 The median OS was 10.4 versus 8.5 months, favouring pembrolizumab (hazard ratio [HR] 0.71, 95% confidence interval [CI] 0.58–0.88; P = 0.0008), and higher levels of PD-L1 expression on tumour cells were associated with better outcomes (HR 0.54, 95% CI 0.38–0.77; P = 0.0002 in the PD-L1 > 50% subgroup). In this setting, the median OS improvement was 13% inferior for patients aged ≥65 years (Table 1) but there was only a small proportion of patients in that upper age cohort, which limits any conclusions.

Table 1 Summary of data from immunotherapy single-agent trials for NSCLC.

In the first-line setting, the Phase 3 KEYNOTE-024 trial randomised NSCLC patients with tumour PD-L1 expression of >50% to pembrolizumab versus standard-of-care platinum-based chemotherapy.45 The median OS was 30 versus 14.2 months, favouring pembrolizumab (death HR 0.49, 95% CI 0.34–0.69, adjusted for crossover). The OS benefit was consistent across subgroups (Table 1). The 3-year survival update confirmed the durable survival benefit of pembrolizumab, with 43.7% of patients alive versus 24.9% on the chemotherapy arm (death HR 0.65, 95% CI 0.50–0.86; P < 0.01).46

The Phase 3 randomised KEYNOTE-042 trial had a similar design and treatment arms but randomised patients with tumour PD-L1 expression >1%.47 The median OS was superior for the pembrolizumab arm at different PD-L1 expression cut-offs (>1, >20 and >50%), although the magnitude of benefit was smaller in the case of lower PD-L1 expression (HR 0.81, 95% CI 0.71–0.93, P = 0.0018, for >1% expression versus HR 0.69, 95% CI 0.56–0.85, P = 0.0003 for >50% expression). Moreover, there was no benefit with pembrolizumab when explored in the subgroup of PD-L1 1–49%. With regard to older patients, the OS benefit was similar across subgroups (Table 1).

No age-specific data on toxicity are available from these three trials but the overall incidence of TRAEs of grades 3–5 varied between 13 and 31% with pembrolizumab versus 35 and 53% with chemotherapy.45,47,48 A 2019 pooled analysis of the above-mentioned Phase 3 trials focused on the efficacy and safety in patients aged 75 years or above and confirmed an OS benefit of pembrolizumab (tumour PD-L1 expression of either ≥1 or ≥50%) versus chemotherapy, with a favourable toxicity profile, similar to their younger counterparts.49,50


The anti-PD-1 monoclonal antibody nivolumab was first evaluated in two Phase 3 trials in patients who had previously been treated with platinum doublet chemotherapy. The CHECKMATE-017 and CHECKMATE-057 trials randomised patients regardless of PD-L1 expression to nivolumab versus docetaxel for squamous and non-squamous NSCLC subtypes, respectively.51,52 Several pooled analyses of both trials with increasing follow-up periods have been published: the 5-year pooled analysis represents the longest survival follow-up with immunotherapy for randomised Phase 3 trials in patients with advanced NSCLC.53,54,55,56 This latest analysis confirmed the long-term OS benefit of nivolumab (HR 0.68, 95% CI 0.59–0.78) with an OS rate at 5 years of 13% versus 3% with docetaxel.55 In the subgroup analysis, the benefit of nivolumab for patients aged 75 years or above was not clearly established considering the small number of patients within this age group in both trials (Table 1). The use of nivolumab as monotherapy had an incidence of TRAEs of grade 3–5 of 10% in the nivolumab pooled analysis compared with 55% for docetaxel.

In the CHECKMATE-026 trial, nivolumab was compared with the standard of care first-line platinum-based chemotherapy for patients with PD-L1 expression ≥1%.57 This trial was negative regarding progression-free survival (PFS), which was its primary endpoint. The Phase 2 CHECKMATE-171 trial evaluated the safety of nivolumab in a European population of pretreated patients with squamous NSCLC58 and reported an incidence of grade 3–4 TRAEs for those aged ≥70 years of 14%, compared with 12% across the study population. Similarly, the Phase 3b/4 CHECKMATE-153 trial assessed the safety profile of nivolumab in North America and reported an incidence of grade 3–4 TRAEs of 12% for those aged ≥70 years compared with 11% for younger patients.59


This anti-PD-L1 monoclonal antibody was explored as monotherapy versus docetaxel in the Phase 3 OAK trial in pretreated NSCLC patients regardless of their PD-L1 expression.60 The median OS was 13.8 months on atezolizumab compared with 9.6 months on docetaxel (HR 0.73, 95% CI 0.62–0.87; P = 0.0003). In the subgroup analysis, older patients (≥65 years) had an additional 14% reduction in the risk of death compared with younger patients (Table 1). No age-specific safety data are available, although the incidence of grade 3–5 TRAEs was 15% for atezolizumab versus 43% with docetaxel. Moreover, the use of atezolizumab delayed the time to deterioration in physical function in the study population (HR 0.75, 95% CI 0.58–0.98).61 Considering that the lung cancer population is predominantly older, with 44% of cases in the UK occurring in patients aged 75 and older, a benefit on physical function is of great clinical significance.62 Data on the use of single-agent atezolizumab in the first-line setting from IMPOWER-110 (NCT02409342) and IMPOWER-111 (NCT02409355) trials are awaited.


The Phase 3 MYSTIC trial investigated durvalumab versus platinum-based chemotherapy versus the combination of durvalumab and tremelimumab, a monoclonal anti-CTLA-4 antibody, in the first-line setting.63 In the subgroup of patients with PD-L1 expression ≥25% (primary analysis subgroup), the median OS for durvalumab versus chemotherapy was 16.3 versus 12.9 months, respectively (HR 0.76, 97.5% CI 0.56–1.02; P = 0.036)—although statistical significance was not achieved, this constitutes a clinically meaningful improvement in OS for durvalumab versus chemotherapy. A more meaningful benefit for older patients (65 years or older) was observed, with HR 0.66 (97.5% CI 0.45–0.95) favoring durvalumab over chemotherapy.64 When comparing durvalumab plus tremelimumab with chemotherapy, the median OS was 11.9 versus 12.9 months (HR 0.85, 98.8% CI 0.61–1.17; P = 0.202) with no benefit in any age groups.63,64 With regard to safety, the incidence of TRAEs of grades 3–5 was 15% with durvalumab versus 35% with chemotherapy. No age-group analyses of TRAEs were carried out.


Chemotherapy coadministered with immunotherapy is a more recent development in the management of patients with advanced NSCLC. A number of reasons exist for potentially better outcomes on a combination. Cytotoxic cell death might create additional antigens that are recognised by the immune system.65 In addition, chemotherapeutic agents can reduce the number of suppressive cells, such as myeloid-derived suppressor cells and Treg cells, that would otherwise limit the efficacy of the immunotherapeutic agents.66 Furthermore, by reducing the tumour bulk, cytotoxic agents allow T-lymphocytes to infiltrate the tumour and recovery of an exhausted immune.67

Pembrolizumab combinations

In KEYNOTE-189,68 a Phase 3 double-blind, randomised placebo-controlled trial of patients with metastatic non-squamous NSCLC and any level of tumour PD-L1 expression, first-line pembrolizumab plus platinum-based chemotherapy (cisplatin or carboplatin) and pemetrexed was superior to platinum-based chemotherapy and pemetrexed in terms of OS (overall HR 0.49, 95% CI 0.38–0.64) and PFS (overall HR 0.52, 95% CI 0.43–0.64). Median OS in the chemoimmunotherapy arm was 22.0 months, versus 10.7 months for the standard chemotherapy arm (HR 0.56, 95% CI 0.45–0.70; P < 0.01).69 In subgroup analyses by age (Table 2), the OS benefit extended to patients of 65 years and over (HR 0.64, 95% CI 0.43–0.95).68 No subgroup analyses by age were conducted for PFS or for any toxicity outcomes. In the chemoimmunotherapy arm, 67.2% of patients of all ages developed TRAEs of grade 3 and above, compared with 65.8% in the chemotherapy arm. The results from KEYNOTE-18968 and its predecessor Phase 2 KEYNOTE-021 trial70,71 led to the widespread approval of pembrolizumab in combination with platinum and pemetrexed for the first-line treatment of metastatic non-squamous NSCLC in patients without EGFR or ALK genomic tumour aberrations, regardless of PD-L1 expression.

Table 2 Summary of data from combination trials of systemic treatments for NSCLC.

For patients with metastatic squamous NSCLC, only one landmark trial to date has demonstrated an OS benefit for chemoimmunotherapy compared with chemotherapy. In KEYNOTE-407,72,73 a Phase 3 double-blind randomised placebo-controlled trial of patients with metastatic squamous NSCLC and any level of tumour cell PD-L1 expression, first-line treatment with pembrolizumab plus carboplatin plus either paclitaxel or nab-paclitaxel was superior to carboplatin plus taxane alone in terms of OS (17.1 versus 11.6 months; HR 0.71, 95% CI 0.58–0.88) and PFS (8.0 versus 5.1 months; HR 0.57, 95% CI 0.47–0.69). In subgroup analyses by age, the PFS benefit extended to older adults (age > 65 years, HR 0.63, 95% CI 0.47–0.84). However, when OS was examined among older adults only, there was no longer a statistically significant benefit (age > 65 years, HR 0.74, 95% CI 0.51–1.07). Overall, TRAEs of grade 3 and above occurred similarly in both arms, affecting 69.8% of patients receiving chemoimmunotherapy and 68.2% of patients receiving chemotherapy. No age-specific data on toxicity are available.

Atezolizumab combinations

In IMpower150,74 an open-label Phase 3 randomised trial of patients with metastatic non-squamous NSCLC and any level of tumour cell PD-L1 expression (including patients with EGFR or ALK genetic alterations), a combination of carboplatin, paclitaxel, bevacizumab plus atezolizumab was superior to carboplatin, paclitaxel and bevacizumab with respect to OS (overall HR 0.78, 95% CI 0.64–0.96) and PFS (overall HR 0.62, 95% CI 0.52–0.74). In a comparison of age groups, PFS was favoured by the chemoimmunotherapy arm in patients below the age of 65 years (HR 0.65) and in those aged 65–74 years (HR 0.52). Among patients aged 75–84 (9% of patients), the HR for PFS was 0.78 but was not statistically significant. The results comparing an additional third arm consisting of carboplatin and paclitaxel plus atezolizumab have not yet been reported. Overall, grade >3 TRAEs were reported in 58.5% of patients in the chemoimmunotherapy arm and 50% in the chemotherapy arm.

In the IMpower130 trial, atezolizumab was also studied in combination with carboplatin and nab-paclitaxel compared with chemotherapy alone in patients with metastatic non-squamous NSCLC,75. PFS (HR 0.65, 95% CI 0.54–0.77) and OS (HR 0.80, 95% CI 0.65–0.99) were improved in the chemoimmunotherapy arm in the intention-to-treat population. When analysed by age group, the PFS benefit of the chemoimmunotherapy arm remained and was similar among younger and older patients (age < 65 years PFS HR 0.64, 95% CI 0.50–0.82; age >65 years PFS HR 0.64, 95% CI 0.50–0.82). By contrast, the OS benefit of the chemoimmunotherapy arm was no longer statistically significant when stratified by age group (age < 65 years OS HR 0.79, 95% CI 0.58–1.08; age >65 years OS HR 0.78, 95% CI 0.58–1.05). Grade >3 TRAEs occurred in 75% of patients in the chemoimmunotherapy arm and 60% in the chemotherapy arm.

Atezolizumab was also studied in patients with metastatic non-squamous NSCLC in combination with carboplatin or cisplatin plus pemetrexed versus chemotherapy alone in the IMpower132 trial.76 PFS (HR 0.60, 95% CI 0.49–0.72) was improved in the chemoimmunotherapy arm compared with the chemotherapy arm, and this improvement was confirmed in age-group analyses as well. Among older patients aged >65 years, the HR for PFS was 0.55 (95% CI 0.42–0.73) compared with a HR of 0.63 (95% CI 0.49–0.80) for younger patients. In the oldest group (aged 75–84 years), the PFS HR was 0.63 (95% CI 0.35–1.13). The interim OS analysis did not demonstrate a benefit at this time (HR 0.81, 95% CI 0.64–1.03), which was not influenced by age group (age < 65 OS HR 0.89, 95% CI 0.65–1.21; age >65 OS HR 0.71, 95% CI 0.50–1.01).

For patients with metastatic squamous NSCLC, the open-label Phase 3 randomised trial IMpower13177 demonstrated a PFS benefit for first-line atezolizumab plus carboplatin and nab-paclitaxel versus carboplatin and nab-paclitaxel alone (HR 0.71, 95% CI 0.60–0.85). The final OS data showed no benefit for the intent-to-treat population (HR 0.88, 95% CI 0.73–1.05; P = 0.158), but on secondary analysis for those with high PD-L1 expression (≥50% PD-L1 expression on tumour cells or ≥10% expression on tumour-infiltrating immune cells) there was an apparent benefit in OS (HR 0.48, 95% CI 0.29–0.81).78 In subgroup analyses by age, only available for PFS, a benefit to all three age groups was demonstrated (age < 65 years HR 0.77, 95% CI 0.61–0.99; age 65–74 years HR 0.66, 95% CI 0.51–0.87; age 75–84 years HR 0.51, 95% CI 0.30–0.84). TRAEs of grade 3 and above occurred in 69% of patients in the chemoimmunotherapy arm compared with 58% in the chemotherapy arm.

Combinations of immunotherapy

Combining different immunotherapy agents that target different checkpoints in T cells is the most recent development in the field of advanced NSCLC. CHECKMATE-227 is a complex randomised Phase 3 trial divided into two parts for the first-line treatment of patients with advanced NSCLC primarily exploring the combination of nivolumab plus ipilimumab versus standard platinum-based chemotherapy. The first part, which has been published, had two independent primary endpoints: PFS with nivolumab plus ipilimumab versus chemotherapy in patients with a high tumour mutational burden (≥10 mutations per megabase);79 and OS with nivolumab plus ipilimumab versus chemotherapy in patients with a tumour PD-L1 expression level of 1% or more.80 For other hierarchical endpoints, the trial included a group with PD-L1 expression below 1% and also treatment arms with nivolumab or nivolumab plus chemotherapy. Focusing on the published data for the primary OS endpoint in the case of PD-L1 expression levels ≥1%, the nivolumab plus ipilimumab combination was superior to the chemotherapy arm (17.1 versus 14.9 months; HR 0.79, 95% CI 0.65–0.96; P = 0.007). In the subgroup analysis, the benefit for the group aged 65–74 years was not clear when compared with younger patients, with a HR of 0.91 (0.70–1.19) versus HR 0.70 (0.55–0.89), respectively. Similarly, the group aged 75 years or more did not seem to benefit, although this was a small group comprising only 81 patients. With regard to toxicity, grade >3 TRAEs were reported in 32.8% of patients in the nivolumab plus ipilimumab arm and 36% in the chemotherapy arm, with more serious adverse events occurring in the immunotherapy arm (24.5% versus 13.9%).

CHECKMATE-817 is a Phase 3b/4 trial primarily exploring the safety (grade 3–5 TRAEs) of a flat dose of nivolumab combined with ipilimumab (standard weight-based dose) in the first-line treatment of advanced NSCLC. The trial included two cohorts: a standard cohort of 391 patients with a performance status (PS) of 0–1, and a smaller, ‘special populations’ cohort of 198 patients comprising those with a PS of 2 or of 0–1 plus other factors that might have excluded them from other clinical studies of immunotherapy agents (asymptomatic untreated brain metastasis, hepatic impairment, renal impairment or human immunodeficiency virus).81,82 In the main cohort (those with PS 0–1), 15% was aged 75 years or above, whilst 22% of the PS 2 group within the special populations’ cohort (comprising 139 patients) was aged 75 years or above. The incidence of grade 3–4 TRAEs was 35% and 26%, respectively, favouring the older, more frail group, with no difference in treatment-related death. Moreover, the overall safety data of nivolumab flat-dosing was identical to the weight-based dosing modality.


Between 30 and 50% of patients diagnosed with NSCLC receive radiotherapy in the early- or late-stage disease setting and, as such, radiotherapy is a valuable treatment modality. Radiotherapy is known to induce immune and inflammatory changes that can prime the tumour microenvironment to initiate an immune response. Moreover, this initial immune priming can be augmented systemically by combining radiotherapy with immunotherapies to relay an abscopal response. Radiation-induced immunogenic cell death induces the release of tumour antigens, dendritic cell maturation, augmentation of T-cell priming, upregulation of MHC-I and PD-L1 expression, and upregulation of the levels of cytokines and chemokines83,84,85,86,87—consequently, interest in combining radiotherapy with immunotherapy agents to improve antitumour immunity and responses has increased.

Clinical evidence on the combination of thoracic radiotherapy and immunotherapy for patients with NSCLC is lacking. However, some data are available on their sequential use.88 A secondary analysis of KEYNOTE-001, a Phase 1 study that included patients with metastatic NSCLC, showed that those who previously received radiotherapy had a significantly longer PFS and OS than non-irradiated patients when subsequently treated with pembrolizumab.88 However, these patients also experienced a greater degree of pulmonary toxicity compared with non-irradiated patients. Although increasing age was associated with improved PFS in this model on univariate analysis; it no longer reached significance on multivariate analysis, which may be linked with the presence of clinical confounding factors.

The efficacy of durvalumab in the setting of unresectable stage III NSCLC following concurrent chemoradiotherapy was explored in the PACIFIC trial.89 Durvalumab significantly prolonged the median OS compared with placebo (HR 0.68, 99.7% CI, 0.47–0.997; P = 0.0025). Nevertheless, the OS benefit was less clear for older patients (Table 2). In this trial, the incidence of pneumonitis of any grade was higher in the durvalumab arm than in the placebo (34% versus 25%), although the rates of grade 3–4 pneumonitis were similar (4% versus 3%). An exploratory analysis investigated the efficacy of durvalumab in patients who developed pneumonitis, and the survival outcomes were similar to the intent-to-treat population.90 Although radiation pneumonitis becomes more common with age,91 this does not appear to be the case for immunotherapy pneumonitis.92


Immune checkpoint inhibition therapy targeting PD-1/PD-L1 has changed the treatment landscape for advanced NSCLC. Although due to the ageing immune system (immunosenescence) there is a concern that older patients might be at risk of lower efficacy and/or increased adverse effects with these agents, limited subgroup analyses from pivotal clinical trials indicate that older patients might gain the same benefit from immunotherapy as younger patients, with an acceptable toxicity profile.

However, methodologically and conceptually, results from the pivotal Phase 3 trials cannot yet be generalised to older patient populations. These trials only included patients with a PS of 0–1; consequently, the evidence in vulnerable/frail patients remains very limited. The median age at trial enrolment was about 10 years younger than the median age of NSCLC diagnosis in Western countries. The subgroup analyses on older patients were conducted post-hoc and the trials not powered for age-group comparison. Data on patients >75 years old are lacking, and any available data in this group are conflicting, potentially reflecting the small sample size of these elderly cohorts, or poorer tolerance of therapy and additional comorbidities within this population.

Moreover, the pivotal Phase 3 trials did not include CGA or geriatric screening at baseline as suggested by current guidelines.93 Prospective studies with a real-world population are therefore required to incorporate geriatric assessments into their design, such as is the case in the ELDERS study. This observational cohort study of 140 patients (with NSCLC or melanoma) was designed with the primary aim of assessing safety, but also to investigate the QoL of immunotherapy in younger and older patients (cut-off at 70 years). The PS value was not part of the selection criteria and the study integrated geriatric screening and assessments for subsequent exploratory analysis. An interim analysis of the first 32 patients with NSCLC reported no significant differences in toxicity between the age groups in a real-world population where 30% of patients were PS 2 and 46% of the older patients failed the geriatric screening (using the G8 tool).94 The final results of this study are expected in late 2020.

It is still not entirely clear whether the poorer PS and increased incidence of comorbidities that can be associated with older age predict for more toxicity and/or less efficacy with immunotherapy. In two large cohort studies of nivolumab, patients with PS 2 had similar adverse events compared with PS 0–1 but poorer outcomes in terms of OS.95,96 However, these results were not reproduced in the PePS2 study assessing pembrolizumab in a PS 2 population, in which the response and OS appeared similar to previous reports in patients with PS 0–1.97 Additionally, the CheckMate-171 trial, which included elderly and PS 2 patients, reported no differences in terms of toxicity and OS between the overall population and the elderly subgroup.58 Real-world data derived from the Italian expanded access programme (EAP) for nivolumab in pretreated patients also suggested a similar OS across age groups and, although toxicities were not analysed separately, their overall incidence was similar to data derived from randomised trials.98,99,100 Further data from an Italian multicentre retrospective study of patients >75 years old treated with anti-PD-1 agents (either nivolumab or pembrolizumab) were also consistent with previous registration trials in terms of toxicity profile and efficacy.101 Therefore, there is currently no need to exclude patients with reasonable performance status from treatment with immunotherapy on the basis of age.

Contrary to chemotherapy, the duration of treatment with immunotherapy is long, and patients can receive treatment for many months or even years. However, the impact of long-term treatment on patient fitness and comorbidities is unclear. In patients experiencing immune-related adverse effects, steroids are recommended—often at high doses and for prolonged courses.102 The impact on older patients of managing these effects is not clear but might be as problematical as immunotherapy treatment itself, as long-term steroid use can influence muscle bulk, bone strength, glucose tolerance and immune function.

The combination of immunotherapy and chemotherapy is now integrated as a standard of care in the first-line treatment setting of NSCLC.103 Although such combinations result in improved response rates, PFS and OS (regardless of PD-L1 status) compared with chemotherapy only, the toxicity rates are higher. Although sequential chemotherapy and immunotherapy might therefore seem a better option for older patients to reduce toxicity, appropriately selected older patients might benefit in some cases from combination strategies. It is therefore imperative to adequately assess older patients within this treatment scenario for a frailty or prefrailty status in order to avoid over- or under-treatment and to determine which patients will be able to tolerate the combination. Older patients are more prone to experience chemotherapy toxicity and are more likely to discontinue chemotherapy as a result;104 determining the aetiology of a given toxicity and managing it appropriately can be even more challenging when combining chemotherapy and immunotherapy. The major concern is that toxicities cause a functional decline that results in a loss of independence and a poorer QoL.

In conclusion, there is an essential need to generate data to address the use of immunotherapy in the older population as a whole, including in vulnerable and pre-frail patients.105 These data should include functional measures of frailty such as the G8, with a formal CGA in patients identified as vulnerable. Endpoints should not only be based around survival or response to treatment shown by imaging but should also include patient-reported outcomes such as maintaining QoL, which might be a more relevant goal in older patients. In addition, a further consideration is the potential impact of immunosenescence on immunotherapy. To this end, various biological markers and tests for immunosenescence could be incorporated into clinical trials to help determine whether the changes in the immune system associated with ageing have any impact on treatment efficacy and/or toxicity. Such assays include an assessment of T-cell phenotype, including the presence of circulating Treg cells and CD8+/CD28 T-cells and response to antigen challenge using EliSpot; the presence of autoantibodies; the presence of inflammatory markers, including the neutrophil to lymphocyte ratio and levels of CRP and IL-6; and an assessment of the stool microbiome for Firmicutes and Bacteroides species. Conducting such trials, however, can be difficult due to the heterogeneity of this population and the complex clinical variables. In addition, pharmaceutical companies might be less interested in focussing their studies on older patients or those with comorbidities where higher rates of adverse events are often encountered. In this regard, a good methodological compromise might be to design Phase 2 studies focusing on such patient populations, or to include specific preplanned subgroup analysis on older patients in pivotal randomised trials. Additionally, functional endpoints and patient-reported outcomes for older individuals could be included as exploratory or secondary endpoints in registration trials. Lastly, real-world data are an invaluable, readily available resource and should be collected and shared to help inform decision making when discussing treatment in these patient groups.


  1. 1.

    SEER. Cancer statistics factsheets: lung and bronchus cancer. (2019).

  2. 2.

    Sawhney, R., Sehl, M. & Naeim, A. Physiologic aspects of aging: impact on cancer management and decision making, part I. Cancer J. 11, 449–460 (2005).

    PubMed  Google Scholar 

  3. 3.

    Sehl, M., Sawhney, R. & Naeim, A. Physiologic aspects of aging: impact on cancer management and decision making, part II. Cancer J. 11, 461–473 (2005).

    PubMed  Google Scholar 

  4. 4.

    Williams, G. R., Mackenzie, A., Magnuson, A., Olin, R., Chapman, A., Mohile, S. et al. Comorbidity in older adults with cancer. J. Geriatr. Oncol. 7, 249–257 (2016).

    PubMed  Google Scholar 

  5. 5.

    Tam-McDevitt, J. Polypharmacy, aging, and cancer. Oncology 22, 1052–1055 (2008).

    PubMed  Google Scholar 

  6. 6.

    Yellen, S. B., Cella, D. F. & Leslie, W. T. Age and clinical decision making in oncology patients. J. Natl Cancer Institute 86, 1766–1770 (1994).

    CAS  Google Scholar 

  7. 7.

    Hurria, A., Dale, W., Mooney, M., Rowland, J. H., Ballman, K. V., Cohen, H. J. et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J. Clin. Oncol. 32, 2587–2594 (2014).

    PubMed  PubMed Central  Google Scholar 

  8. 8.

    Devons, C. A. Comprehensive geriatric assessment: making the most of the aging years. Curr. Opin. Clin. Nutr. Metab. Care 5, 19–24 (2002).

    PubMed  Google Scholar 

  9. 9.

    Extermann, M., Aapro, M., Bernabei, R., Cohen, H. J., Droz, J. P., Lichtman, S. et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit. Rev. Oncol. Hematol. 55, 241–252 (2005).

    PubMed  Google Scholar 

  10. 10.

    Mohile, S. G., Dale, W., Somerfield, M. R., Schonberg, M. A., Boyd, C. M., Burhenn, P. S. et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO Guideline for Geriatric Oncology. J. Clin. Oncol. 36, 2326–2347 (2018).

    PubMed  PubMed Central  Google Scholar 

  11. 11.

    Antonio, M., Saldana, J., Linares, J., Ruffinelli, J. C., Palmero, R., Navarro, A. et al. Geriatric assessment may help decision-making in elderly patients with inoperable, locally advanced non-small-cell lung cancer. Br. J. Cancer 118, 639–647 (2018).

    PubMed  PubMed Central  Google Scholar 

  12. 12.

    Maione, P., Perrone, F., Gallo, C., Manzione, L., Piantedosi, F., Barbera, S. et al. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J. Clin. Oncol. 23, 6865–6872 (2005).

    PubMed  Google Scholar 

  13. 13.

    Extermann, M., Boler, I., Reich, R. R., Lyman, G. H., Brown, R. H., DeFelice, J. et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer 118, 3377–3386 (2012).

    PubMed  Google Scholar 

  14. 14.

    Hurria, A., Togawa, K., Mohile, S. G., Owusu, C., Klepin, H. D., Gross, C. P. et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J. Clin. Oncol. 29, 3457–3465 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Decoster, L., Van Puyvelde, K., Mohile, S., Wedding, U., Basso, U., Colloca, G. et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendationsdagger. Ann. Oncol. 26, 288–300 (2015).

    CAS  PubMed  Google Scholar 

  16. 16.

    Fruh, M., Rolland, E., Pignon, J. P., Seymour, L., Ding, K., Tribodet, H. et al. Pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected non-small-cell lung cancer. J. Clin. Oncol. 26, 3573–3581 (2008).

    CAS  PubMed  Google Scholar 

  17. 17.

    Pepe, C., Hasan, B., Winton, T. L., Seymour, L., Graham, B., Livingston, R. B. et al. Adjuvant vinorelbine and cisplatin in elderly patients: National Cancer Institute of Canada and Intergroup Study JBR.10. J. Clin. Oncol. 25, 1553–1561 (2007).

    CAS  PubMed  Google Scholar 

  18. 18.

    Battisti, N. M. L., Sehovic, M. & Extermann, M. Assessment of the external validity of the National Comprehensive Cancer Network and European Society for Medical Oncology Guidelines for non-small-cell lung cancer in a population of patients aged 80 years and older. Clin. Lung Cancer 18, 460–471 (2017).

    PubMed  Google Scholar 

  19. 19.

    Abe, T., Takeda, K., Ohe, Y., Kudoh, S., Ichinose, Y., Okamoto, H. et al. Randomized phase III trial comparing weekly docetaxel plus cisplatin versus docetaxel monotherapy every 3 weeks in elderly patients with advanced non-small-cell lung cancer: the intergroup trial JCOG0803/WJOG4307L. J. Clin. Oncol. 33, 575–581 (2015).

    CAS  PubMed  Google Scholar 

  20. 20.

    Gridelli, C., Perrone, F., Gallo, C., Cigolari, S., Rossi, A., Piantedosi, F. et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J. Natl Cancer Institute 95, 362–372 (2003).

    CAS  Google Scholar 

  21. 21.

    Quoix, E., Zalcman, G., Oster, J. P., Westeel, V., Pichon, E., Lavole, A. et al. Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial. Lancet 378, 1079–1088 (2011).

    CAS  PubMed  Google Scholar 

  22. 22.

    The Elderly Lung Cancer Vinorelbine Italian Study Group. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J. Natl Cancer Institute 91, 66–72 (1999)

  23. 23.

    Kudoh, S., Takeda, K., Nakagawa, K., Takada, M., Katakami, N., Matsui, K. et al. Phase III study of docetaxel compared with vinorelbine in elderly patients with advanced non-small-cell lung cancer: results of the West Japan Thoracic Oncology Group Trial (WJTOG 9904). J. Clin. Oncol. 24, 3657–3663 (2006).

    CAS  PubMed  Google Scholar 

  24. 24.

    Hanna, N., Johnson, D., Temin, S., Baker, S. Jr., Brahmer, J., Ellis, P. M. et al. Systemic therapy for stage IV non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J. Clin. Oncol. 35, 3484–3515 (2017).

    CAS  PubMed  Google Scholar 

  25. 25.

    Gridelli, C., Morabito, A., Cavanna, L., Luciani, A., Maione, P., Bonanno, L. et al. Cisplatin-based first-line treatment of elderly patients with advanced non-small-cell lung cancer: joint analysis of MILES-3 and MILES-4 phase III trials. J. Clin. Oncol. 36, 2585–2592 (2018).

    CAS  PubMed  Google Scholar 

  26. 26.

    Chen, D. S. & Mellman, I. Elements of cancer immunity and the cancer-immune set point. Nature 541, 321–330 (2017).

    CAS  PubMed  Google Scholar 

  27. 27.

    Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. 28.

    Cavnar, S., Valencia, P., Brock, J., Wallenstein, J. & Panier, V. The immuno-oncology race: myths and emerging realities. Nat. Rev. Drug Discov. 16, 83–84 (2017).

    CAS  PubMed  Google Scholar 

  29. 29.

    Tang, J., Shalabi, A. & Hubbard-Lucey, V. M. Comprehensive analysis of the clinical immuno-oncology landscape. Ann. Oncol. 29, 84–91 (2018).

    CAS  PubMed  Google Scholar 

  30. 30.

    Naidoo, J., Page, D. B., Li, B. T., Connell, L. C., Schindler, K., Lacouture, M. E. et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann. Oncol. 26, 2375–2391 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. 31.

    Kirkwood, T. B. & Austad, S. N. Why do we age? Nature. 408, 233–238 (2000).

    CAS  PubMed  Google Scholar 

  32. 32.

    Nikolich-Zugich, J. The twilight of immunity: emerging concepts in aging of the immune system. Nat. Immunol. 19, 10–19 (2018).

    CAS  PubMed  Google Scholar 

  33. 33.

    Molony, R. D., Malawista, A. & Montgomery, R. R. Reduced dynamic range of antiviral innate immune responses in aging. Exp. Gerontol. 107, 130–135 (2018).

    CAS  PubMed  Google Scholar 

  34. 34.

    Gavazzi, G. & Krause, K. H. Ageing and infection. Lancet Infect. Dis. 2, 659–666 (2002).

    PubMed  Google Scholar 

  35. 35.

    Hazeldine, J. & Lord, J. M. Innate immunesenescence: underlying mechanisms and clinical relevance. Biogerontology 16, 187–201 (2015).

    CAS  PubMed  Google Scholar 

  36. 36.

    Weng, N. P., Akbar, A. N. & Goronzy, J. CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 30, 306–312 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. 37.

    Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V. et al. Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans. J. Immunol. 192, 2143–2155 (2014).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. 38.

    Seyda, M., Elkhal, A., Quante, M., Falk, C. S. & Tullius, S. G. T cells going innate. Trends Immunol. 37, 546–556 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  39. 39.

    Manoussakis, M. N., Tzioufas, A. G., Silis, M. P., Pange, P. J., Goudevenos, J. & Moutsopoulos, H. M. High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin. Exp. Immunol. 69, 557–565 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. 40.

    Verschoor, C. P., Johnstone, J., Millar, J., Dorrington, M. G., Habibagahi, M., Lelic, A. et al. Blood CD33(+)HLA-DR(-) myeloid-derived suppressor cells are increased with age and a history of cancer. J. Leuk. Biol. 93, 633–637 (2013).

    CAS  Google Scholar 

  41. 41.

    Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A. et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 181, 1835–1848 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

  42. 42.

    De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett. 579, 2035–2039 (2005).

    PubMed  Google Scholar 

  43. 43.

    Johnson, D. E., O’Keefe, R. A. & Grandis, J. R. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat. Rev. Clin. Oncol. 15, 234–248 (2018).

    CAS  PubMed  PubMed Central  Google Scholar 

  44. 44.

    Routy, B., Gopalakrishnan, V., Daillere, R., Zitvogel, L., Wargo, J. A. & Kroemer, G. The gut microbiota influences anticancer immunosurveillance and general health. Nat. Rev. Clin. Oncol. 15, 382–396 (2018).

    CAS  PubMed  Google Scholar 

  45. 45.

    Reck, M., Rodríguez–Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A. et al. Updated analysis of KEYNOTE-024: pembrolizumab versus platinum-based chemotherapy for advanced non–small-cell lung cancer with PD-L1 tumor proportion Score of 50% or Greater. J. Clin. Oncol. 37, 537–546 (2019).

    CAS  PubMed  Google Scholar 

  46. 46.

    Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A. et al. KEYNOTE-024 3-year survival update: pembrolizumab vs platinum-based chemotherapy for advanced non-small-cell lung cancer. J. Thorac. Oncol. 14, S243 (2019).

    Google Scholar 

  47. 47.

    Mok, T. S. K., Wu, Y.-L., Kudaba, I., Kowalski, D. M., Cho, B. C., Turna, H. Z. et al. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial. Lancet 393, 1819–1830 (2019).

    CAS  PubMed  Google Scholar 

  48. 48.

    Herbst, R. S., Baas, P., Kim, D.-W., Felip, E., Pérez-Gracia, J. L., Han, J.-Y. et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 387, 1540–1550 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  49. 49.

    Nosaki, K., Hosomi, Y., Saka, H., Baas, P., de Castro, G., Jr., Reck, M. et al. Safety and efficacy of pembrolizumab (Pembro) monotherapy in elderly patients (Pts) with PD-L1–positive advanced NSCLC: pooled analysis from KEYNOTE-010, −024, and −042. Ann. Oncol. 30(Suppl_2), ii48–48 (2019).

    Google Scholar 

  50. 50.

    Nosaki, K., Saka, H., Hosomi, Y., Baas, P., de Castro, G. Jr., Reck, M. et al. Safety and efficacy of pembrolizumab monotherapy in elderly patients with PD-L1-positive advanced non-small-cell lung cancer: Pooled analysis from the KEYNOTE-010, KEYNOTE-024, and KEYNOTE-042 studies. Lung Cancer 135, 188–195 (2019).

    PubMed  Google Scholar 

  51. 51.

    Brahmer, J., Reckamp, K. L., Baas, P., Crinò, L., Eberhardt, W. E. E., Poddubskaya, E. et al. Nivolumab versus docetaxel in advanced squamous-cell non–small-cell lung cancer. N. Engl. J. Med. 373, 123–135 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. 52.

    Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D. R., Steins, M., Ready, N. E. et al. Nivolumab versus docetaxel in advanced nonsquamous non–small-cell lung cancer. N. Engl. J. Med. 373, 1627–1639 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  53. 53.

    Vokes, E. E., Ready, N., Felip, E., Horn, L., Burgio, M. A., Antonia, S. J. et al. Nivolumab versus docetaxel in previously treated advanced non-small-cell lung cancer (CheckMate 017 and CheckMate 057): 3-year update and outcomes in patients with liver metastases. Ann. Oncol. 29, 959–965 (2018).

    CAS  PubMed  Google Scholar 

  54. 54.

    Horn, L., Spigel, D. R., Vokes, E. E., Holgado, E., Ready, N., Steins, M. et al. Nivolumab versus docetaxel in previously treated patients with advanced non-small-cell lung cancer: two-year outcomes from two randomized, open-label, phase III trials (CheckMate 017 and CheckMate 057). J. Clin. Oncol. 35, 3924–3933 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  55. 55.

    Gettinger, S., Borghaei, H., Brahmer, J., Chow, L., Burgio, M., De Castro Carpeno, J. et al. Five-year outcomes from the randomized, phase 3 trials CheckMate 017/057: nivolumab vs docetaxel in previously treated NSCLC. J. Thorac. Oncol. 14, S244–S245 (2019).

    Google Scholar 

  56. 56.

    Antonia, S. J., Borghaei, H., Ramalingam, S. S., Horn, L., De Castro Carpeño, J., Pluzanski, A. et al. Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis. Lancet Oncol. 20, 1395–1408 (2019).

    CAS  PubMed  PubMed Central  Google Scholar 

  57. 57.

    Carbone, D. P., Reck, M., Paz-Ares, L., Creelan, B., Horn, L., Steins, M. et al. First-line nivolumab in stage IV or recurrent non–small-cell lung cancer. N. Engl. J. Med. 376, 2415–2426 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  58. 58.

    Popat, S., Ardizzoni, A., Ciuleanu, T., Cobo Dols, M., Laktionov, K., Szilasi, M. et al. Nivolumab in previously treated patients with metastatic squamous NSCLC: results of a European single-arm, phase 2 trial (CheckMate 171) including patients aged ≥70 years and with poor performance status. Ann. Oncol. 28(suppl_5), 463–463 (2017).

    Google Scholar 

  59. 59.

    Spigel, D., Schwartzberg, L., Waterhouse, D., Chandler, J., Hussein, M., Jotte, R. et al. Is nivolumab safe and effective in elderly and PS2 patients with non-small cell lung cancer (NSCLC)? Results of CheckMate 153: Topic: IT. J. Thorac. Oncol. 12, S1287–S1288 (2017).

    Google Scholar 

  60. 60.

    Rittmeyer, A., Barlesi, F., Waterkamp, D., Park, K., Ciardiello, F., von Pawel, J. et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 389, 255–265 (2017).

    Google Scholar 

  61. 61.

    Bordoni, R., Ciardiello, F., von Pawel, J., Cortinovis, D., Karagiannis, T., Ballinger, M. et al. Patient-reported outcomes in OAK: a phase III study of atezolizumab versus docetaxel in advanced non-small-cell lung cancer. Clin. Lung Cancer 19, 441–449 (2018).

    CAS  PubMed  Google Scholar 

  62. 62.

    CRUK. Cancer statistics in lung cancer. (2019).

  63. 63.

    Rizvi, N. A., Chul Cho, B., Reinmuth, N., Lee, K. H., Ahn, M. J., Luft, A. et al. Durvalumab with or without tremelimumab vs platinum-based chemotherapy as first-line treatment for metastatic non-small cell lung cancer: MYSTIC. Ann. Oncol. 29(suppl_10), X40–41 (2018).

    Google Scholar 

  64. 64.

    Cho, B. C., Reinmuth, N., Lee, K. H., Ahn, M. J., Luft, A., den Heuvel, M. V. et al. Efficacy and safety of first-line durvalumab (D) ± tremelimumab (T) vs platinum-based chemotherapy (CT) based on clinical characteristics in patients with metastatic (m) NSCLC: Results from MYSTIC. Ann. Oncol. 30(Supplement_2), ii79–80 (2019).

    Google Scholar 

  65. 65.

    Bracci, L., Schiavoni, G., Sistigu, A. & Belardelli, F. Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer. Cell Death Differ. 21, 15–25 (2014).

    CAS  PubMed  Google Scholar 

  66. 66.

    Wang, Z., Till, B. & Gao, Q. Chemotherapeutic agent-mediated elimination of myeloid-derived suppressor cells. Oncoimmunology 6, e1331807 (2017).

    PubMed  PubMed Central  Google Scholar 

  67. 67.

    Huang, A. C., Postow, M. A., Orlowski, R. J., Mick, R., Bengsch, B., Manne, S. et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545, 60–65 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  68. 68.

    Gandhi, L., Rodriguez-Abreu, D., Gadgeel, S., Esteban, E., Felip, E., De Angelis, F. et al. Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer. N. Engl. J. Med. 378, 2078–2092 (2018).

    CAS  PubMed  Google Scholar 

  69. 69.

    Gadgeel, S. M., Garassino, M. C., Esteban, E., Speranza, G., Felip, E., Hochmair, M. J. et al. KEYNOTE-189: Updated OS and progression after the next line of therapy (PFS2) with pembrolizumab (pembro) plus chemo with pemetrexed and platinum vs placebo plus chemo for metastatic nonsquamous NSCLC. J. Clin. Oncol. 37(15_suppl), 9013 (2019).

    Google Scholar 

  70. 70.

    Langer, C. J., Gadgeel, S. M., Borghaei, H., Papadimitrakopoulou, V. A., Patnaik, A., Powell, S. F. et al. Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Lancet Oncol. 17, 1497–1508 (2016).

    CAS  PubMed  PubMed Central  Google Scholar 

  71. 71.

    Borghaei, H., Langer, C. J., Gadgeel, S., Papadimitrakopoulou, V. A., Patnaik, A., Powell, S. F. et al. 24-month overall survival from KEYNOTE-021 cohort G: pemetrexed and carboplatin with or without pembrolizumab as first-line therapy for advanced nonsquamous non-small cell lung cancer. J. Thorac. Oncol. 14, 124–129 (2019).

    CAS  PubMed  Google Scholar 

  72. 72.

    Paz-Ares, L., Luft, A., Vicente, D., Tafreshi, A., Gumus, M., Mazieres, J. et al. Pembrolizumab plus chemotherapy for squamous non-small-cell lung cancer. N. Engl. J. Med. 379, 2040–2051 (2018).

    CAS  PubMed  Google Scholar 

  73. 73.

    Paz-Ares, L., Vicente, D., Tafreshi, A., Robinson, A., Soto Parra, H., Mazières, J. et al. Pembrolizumab (pembro) + chemotherapy (chemo) in metastatic squamous NSCLC: final analysis and progression after the next line of therapy (PFS2) in KEYNOTE-407. Ann. Oncol. 30(Suppl_5), V918–919 (2019).

    Google Scholar 

  74. 74.

    Socinski, M. A., Jotte, R. M., Cappuzzo, F., Orlandi, F., Stroyakovskiy, D., Nogami, N. et al. Atezolizumab for first-line treatment of metastatic nonsquamous NSCLC. N. Engl. J. Med. 378, 2288–2301 (2018).

    CAS  Google Scholar 

  75. 75.

    West, H., McCleod, M., Hussein, M., Morabito, A., Rittmeyer, A., Conter, H. J. et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 20, 924–937 (2019).

    CAS  PubMed  Google Scholar 

  76. 76.

    Barlesi, F., Nishio, M., Cobo, M., Steele, N., Paramonov, V., Parente, B. et al. IMpower132: efficacy of atezolizumab + carboplatin/cisplatin + pemetrexed as 1L treatment in key subgroups with stage IV non-squamous NSCLC. Ann. Oncol. 29(S8), VIII743–744 (2018).

    Google Scholar 

  77. 77.

    Jotte, R. M., Cappuzzo, F., Vynnychenko, I., Stroyakovskiy, D., Abreu, D. R., Hussein, M. A. et al. IMpower131: Primary PFS and safety analysis of a randomized phase III study of atezolizumab + carboplatin + paclitaxel or nab-paclitaxel vs carboplatin + nab-paclitaxel as 1L therapy in advanced squamous NSCLC. J. Clin. Oncol. 36(S18), LBA9000 (2018).

    Google Scholar 

  78. 78.

    Jotte, R., Cappuzzo, F., Vynnychenko, I., Stroyakovskiy, D., Abreu, D. R., Hussein, M. et al. IMpower131: final OS results of carboplatin + nab-paclitaxel +/- atezolizumab in advanced squamous NSCLC. J. Thorac. Oncol. 14, S243–S244 (2019).

    Google Scholar 

  79. 79.

    Hellmann, M. D., Ciuleanu, T.-E., Pluzanski, A., Lee, J. S., Otterson, G. A., Audigier-Valette, C. et al. Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden. N. Engl. J. Med. 378, 2093–2104 (2018).

    CAS  PubMed  PubMed Central  Google Scholar 

  80. 80.

    Hellmann, M. D., Paz-Ares, L., Bernabe Caro, R., Zurawski, B., Kim, S. W., Carcereny Costa, E. et al. Nivolumab plus ipilimumab in advanced non-small-cell lung cancer. N. Engl. J. Med. 381, 2020–2031 (2019).

    CAS  PubMed  Google Scholar 

  81. 81.

    Paz-Ares, L., Urban, L., Audigier-Valette, C., Grossi, F., Jao, K., Aucoin, J. et al. CheckMate 817: safety of flat-dose nivolumab plus weight-based ipilimumab for the first-line (1L) treatment of advanced NSCLC. J. Thorac. Oncol. 13, S493 (2018).

    Google Scholar 

  82. 82.

    Barlesi, F., Audigier-Valette, C., Felip, E., Ciuleanu, T., Jao, K., Rijavec, E. et al. CheckMate 817: first-line nivolumab + ipilimumab in patients with ECOG PS 2 and other special populations with advanced NSCLC. J. Thorac. Oncol. 14, S214–S215 (2019).

    Google Scholar 

  83. 83.

    Demaria, S., Ng, B., Devitt, M. L., Babb, J. S., Kawashima, N., Liebes, L. et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int. J. Radiat. Oncol. Biol. Phys. 58, 862–870 (2004).

    PubMed  Google Scholar 

  84. 84.

    Wang, X., Schoenhals, J. E., Li, A., Valdecanas, D. R., Ye, H., Zang, F. et al. Suppression of Type I IFN signaling in tumors mediates resistance to anti-PD-1 treatment that can be overcome by radiotherapy. Cancer Res. 77, 839–850 (2017).

    CAS  Google Scholar 

  85. 85.

    Dovedi, S. J., Adlard, A. L., Lipowska-Bhalla, G., McKenna, C., Jones, S., Cheadle, E. J. et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 74, 5458 (2014).

    CAS  PubMed  Google Scholar 

  86. 86.

    Sato, H., Niimi, A., Yasuhara, T., Permata, T. B. M., Hagiwara, Y., Isono, M. et al. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nat. Commun. 8, 1751 (2017).

    PubMed  PubMed Central  Google Scholar 

  87. 87.

    Barker, H. E., Paget, J. T., Khan, A. A. & Harrington, K. J. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Nat. Rev. Cancer 15, 409–425 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  88. 88.

    Shaverdian, N., Lisberg, A. E., Bornazyan, K., Veruttipong, D., Goldman, J. W., Formenti, S. C. et al. Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: a secondary analysis of the KEYNOTE-001 phase 1 trial. Lancet Oncol. 18, 895–903 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  89. 89.

    Antonia, S. J., Villegas, A., Daniel, D., Vicente, D., Murakami, S., Hui, R. et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N. Engl. J. Med. 379, 2342–2350 (2018).

    CAS  PubMed  Google Scholar 

  90. 90.

    Vansteenkiste, J. F., Naidoo, J., Faivre-Finn, C., Özgüroğlu, M., Villegas, A., Daniel, D. et al. Efficacy of durvalumab in patients with stage III NSCLC who experience pneumonitis (PACIFIC). Ann. Oncol. 30(Supp_5), V592–593 (2019).

    Google Scholar 

  91. 91.

    Palma, D. A., Senan, S., Tsujino, K., Barriger, R. B., Rengan, R., Moreno, M. et al. Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis. Int. J. Radiat. Oncol. Biol Phys. 85, 444–450 (2013).

    PubMed  Google Scholar 

  92. 92.

    Voong, K. R., Hazell, S. Z., Fu, W., Hu, C., Lin, C. T., Ding, K. et al. Relationship between prior radiotherapy and Checkpoint-inhibitor pneumonitis in patients with advanced non-small-cell lung cancer. Clin. Lung Cancer 20, e470–e479 (2019).

    PubMed  Google Scholar 

  93. 93.

    Mohile, S. G., Dale, W., Somerfield, M. R., Schonberg, M. A., Boyd, C. M., Burhenn, P. S. et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO Guideline for Geriatric Oncology. J. Clin. Oncol. 36, 2326–2347 (2018).

    PubMed  PubMed Central  Google Scholar 

  94. 94.

    Gomes, F., Woolley, S., Califano, R., Summers, Y., Baker, K., Burns, K. et al. Elderly lung cancer patients on immunotherapy: preliminary results from the ELDERS study. J. Thorac. Oncol. 12, S1841–S1842 (2017).

    Google Scholar 

  95. 95.

    Popat, S., Ardizzoni, A., Ciuleanu, T., Cobo Dols, M., Laktionov, K., Szilasi, M. et al. 1303PDNivolumab in previously treated patients with metastatic squamous NSCLC: Results of a European single-arm, phase 2 trial (CheckMate 171) including patients aged ≥70 years and with poor performance status. Ann. Oncol. 28(suppl_5), V463–463 (2017).

    Google Scholar 

  96. 96.

    Spigel, D., Schwartzberg, L., Waterhouse, D., Chandler, J., Hussein, M., Jotte, R. et al. P3.02c-026 is nivolumab safe and effective in elderly and PS2 patients with non-small cell lung cancer (NSCLC)? Results of CheckMate 153: Topic: IT. J. Thorac. Oncol. 12, S1287–S1288 (2017).

    Google Scholar 

  97. 97.

    Middleton, G., Brock, K., Summers, Y., Connibear, J., Shah, R., Ottensmeier, C. et al. Pembrolizumab in performance status 2 patients with non-small cell lung cancer (NSCLC): results of the PePS2 trial. Ann. Oncol. 29(suppl_8), VIII497–497 (2018).

    Google Scholar 

  98. 98.

    Grossi, F., Crino, L., Logroscino, A., Canova, S., Delmonte, A., Melotti, B. et al. Use of nivolumab in elderly patients with advanced squamous non-small-cell lung cancer: results from the Italian cohort of an expanded access programme. Euro. J. Cancer 100, 126–134 (2018).

    CAS  Google Scholar 

  99. 99.

    Migliorino, M. R., Gelibter, A., Grossi, F., Fagnani, D., Bordi, P., Franchina, T. et al. Use of nivolumab in elderly patients with advanced non-squamous NSCLC: results from the Italian expanded access program (EAP). Ann. Oncol. 28(suppl_5), V471–471 (2017).

    Google Scholar 

  100. 100.

    Grossi, F., Genova, C., Crinò, L., Delmonte, A., Turci, D., Signorelli, D. et al. Real-life results from the overall population and key subgroups within the Italian cohort of nivolumab expanded access program in non-squamous non–small cell lung cancer. Euro. J. Cancer 123, 72–80 (2019).

    CAS  Google Scholar 

  101. 101.

    Luciani, A., Toschi, L., Fava, S., Cortinovis, D., Filipazzi, V., Tuzi, A. et al. 1472PImmunotherapy in elderly patients (≥ 75 yrs) with advanced non-small cell lung cancer (NSCLC): a multicenter Italian experience. Ann. Oncol. 29(suppl_8), VIII533–533 (2018).

    Google Scholar 

  102. 102.

    Haanen, J., Carbonnel, F., Robert, C., Kerr, K. M., Peters, S., Larkin, J. et al. Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 28(suppl_4), iv119–iv142 (2017).

    CAS  Google Scholar 

  103. 103.

    Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C. et al. Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 29(Suppl 4), iv192–iv237 (2018).

    CAS  PubMed  Google Scholar 

  104. 104.

    Gajra, A., Zemla, T. J., Jatoi, A., Feliciano, J. L., Wong, M. L., Chen, H. et al. Time-to-treatment-failure and related outcomes among 1000+ advanced non-small cell lung cancer patients: comparisons between older versus younger patients (Alliance A151711). J. Thorac. Oncol. 13, 996–1003 (2018).

    PubMed  PubMed Central  Google Scholar 

  105. 105.

    Wildiers, H., Mauer, M., Pallis, A., Hurria, A., Mohile, S. G., Luciani, A. et al. End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer–Alliance for Clinical Trials in Oncology–International Society Of Geriatric Oncology position article. J. Clin. Oncol. 31, 3711–3718 (2013).

    PubMed  Google Scholar 

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We would like to thank the International Society of Geriatric Oncology (SIOG) for their support.

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F.G. proposed the review topic and co-ordinated the review. N.B. wrote the introduction. A.G. wrote the immunotherapy introductory section. F.G. wrote the single-agent immunotherapy section. M.W. wrote the combination section on immunotherapy and chemotherapy with F.G. collaboration. M.K. and T.K. wrote the radioimmunotherapy section. A.L. and A.G. wrote the discussion. All authors provided feedback on the entire review.

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Correspondence to Fabio Gomes.

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M.W. has reported a conflict of interest outside of the submitted work (immediate family member is an employee of Genentech with stock ownership). N.B. has reported a conflict of interest outside of the submitted work (speaker fees from Pfizer, travel grants from Genomic Health). A.G. is an Editorial Board Member of the British Journal of Cancer. The other authors have no relevant conflicts of interest to declare.

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Gomes, F., Wong, M., Battisti, N.M.L. et al. Immunotherapy in older patients with non-small cell lung cancer: Young International Society of Geriatric Oncology position paper. Br J Cancer 123, 874–884 (2020).

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