Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity

Summary

Phosphatases of regenerating liver (PRL1–3) are among the most oncogenic protein phosphatases but their mechanism of action is poorly understood. Multiple substrates have been proposed as well as a non-catalytic function regulating magnesium transport. Our recent identification of a catalytically inactive PRL mutant that retains oncogenicity in a mouse model promises to resolve the question of whether PRLs act as phosphatases or pseudo-phosphatases in different cancer models.

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Fig. 1: PRL3 acts as a pseudo-phosphatase.

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K.G. and H.M. contributed to the writing, revision, and approval of this manuscript.

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Correspondence to Kalle Gehring.

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This work was supported by the Natural Sciences and Engineering Research Council of Canada.

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Gehring, K., Miki, H. Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity. Br J Cancer (2020). https://doi.org/10.1038/s41416-020-01194-9

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