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Medication-related osteonecrosis of the jaw in a paediatric patient taking denosumab: a case report

British Dental Journal volume 236, pages 453–456 (2024)Cite this article

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a known complication of antiresorptive and anti-angiogenic therapies in adults. Increasingly, these drugs are being prescribed for children with a variety of conditions, such as osteogenesis imperfecta and cancers of the bone. Review of the literature, however, reveals no reported paediatric MRONJ cases to date. We present such a case in a nine-year-old female patient with a vertebral aneurysmal bone cyst, who received dental extractions subsequent to denosumab therapy.

Key points

  • Increase awareness of the existence of paediatric medication-related osteonecrosis of the jaw.

  • Highlight the possible impact of dental treatment on children on antiresorptive medication.

  • Encourage further reporting of cases for future review.

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Authors and Affiliations

  1. Dental Core Trainee 2, Oral Surgery and Oral Medicine, School of Dentistry, Belfast, UK

    Dominic Innes-Taylor

  2. Consultant Oral Surgeon, School of Dentistry, Belfast, UK

    Vicky Adams

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  1. Dominic Innes-Taylor
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  2. Vicky Adams
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Dominic Innes-Taylor - designer and writer of the article. Vicky Adams - reviewer and editor.

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Correspondence to Dominic Innes-Taylor.

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Innes-Taylor, D., Adams, V. Medication-related osteonecrosis of the jaw in a paediatric patient taking denosumab: a case report. Br Dent J 236, 453–456 (2024). https://doi.org/10.1038/s41415-024-7139-8

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  • DOI: https://doi.org/10.1038/s41415-024-7139-8

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