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Oral medicine considerations for the older patient

Abstract

With the proportion of the world population aged over 60 years expected to nearly double to 22% by 2050, health care professionals are faced with the challenge of ensuring they are ready to address this demographic shift. As people age, they are more likely to develop comorbidities which have implications for their oral health. The effects of polypharmacy used to address these underlying health problems can also influence the oral health of older-aged patients. From a clinician's perspective, an awareness of the variety of conditions associated with old age, such as oral-mucosal disease, swellings and manifestations of underlying health conditions, are required to ensure appropriate referral, investigation and management, both in primary and secondary care settings. This article aims to provide the practitioner with an overview of orofacial and oral mucosal conditions commonly encountered with the older patient.

Key points

  • Older patients are more likely to have established or undiagnosed medical comorbities which should be considered as a potential cause for their clinical presentation.

  • It is the clinician's duty to be conscientious when prescribing for older patients in terms of the side effects, interactions and oral manifestations associated with each medication.

  • If oral lesions do not resolve following first line management, referral to specialist hospital services should be considered.

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References

  1. World Health Organisation. Ageing and health. 2022. Available at https://www.who.int/news-room/fact-sheets/detail/ageing-and-health (accessed January 2024).

  2. Chan A K, Tamrakar M, Jiang C M, Lo E C, Leung K C, Chu C-H. Common Medical and Dental Problems of Older Adults: A Narrative Review. Geriatrics 2021; 6: 76.

  3. Rohini S, Sherlin H J, Jayaraj G. Prevalence of oral mucosal lesions among elderly population in Chennai: a survey. J Oral Med Oral Surg 2020; 26: 10.

  4. Dodds M W, Haddou M W, Day J E. The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a systematic review and meta-analysis. BMC Oral Health 2023; 23: 406.

  5. Chengappa R, Narayanan V, Khan A, Rakaraddi M P, Puttaswamy K, Puttabuddi J H. Utility of two methodologies in the clinical assessment of oral dryness in postmenopausal women. J Midlife Health 2016; 7: 114-118.

  6. Age UK. Age UK calls for a more considered approach to prescribing medicines for our older population. 2019. Available at https://www.ageuk.org.uk/latest-press/articles/2019/august/age-uk-calls-for-a-more-considered-approach-to-prescribing-medicines-for-older-people/ (accessed January 2024).

  7. Porter S R, Mercadante V, Fedele S. Oral manifestations of systemic disease. Br Dent J 2017; 223: 683-691.

  8. Arany S, Kopycka-Kedzierawski D T, Caprio T V, Watson G E. Anticholinergic medication: Related dry mouth and effects on the salivary glands. Oral Surg Oral Med Oral Pathol Oral Radiol 2021; 132: 662-670.

  9. Scully C. Drug effects on salivary glands: dry mouth. Oral Dis 2003; 9: 165-176.

  10. Prasanthi B, Kannan N, Patil R. Effect of diuretics on salivary flow, composition and oral health status: A clinico-biochemical study. Ann Med Health Sci Res 2014; 4: 549-553.

  11. Rahiotis C, Petraki V, Mitrou P. Changes in saliva characteristics and carious status related to metabolic control in patients with type 2 diabetes mellitus. J Dent 2021; 108: 103,629.

  12. Choudhry H S, Hosseini S, Choudhry H S, Fatahzadeh M, Khianey R, Dastjerdi M H. Updates in diagnostics, treatments, and correlations between oral and ocular manifestations of Sjogren's syndrome. Ocul Surf 2022; 26: 75-87.

  13. Negrini S, Emmi G, Greco M et al. Sjögren's syndrome: a systemic autoimmune disease. Clin Exp Med 2022; 22: 9-25.

  14. Shiboski C H, Shiboski S C, Seror R et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome. Ann Rheum Dis 2017; 76: 9-16.

  15. Fasano M, D'Onofrio I, Belfiore M P et al. Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy. Cancers (Basel) 2022; 14: 472.

  16. Tribius S, Bergelt C. Intensity-modulated radiotherapy versus conventional and 3D conformal radiotherapy in patients with head and neck cancer: Is there a worthwhile quality of life gain? Cancer Treat Rev 2011; 37: 511-519.

  17. Gil-Montoya J, Ferreira de Mello A L, Barrios R, Gonzalez-Moles M A, Bravo M. Oral health in the elderly patient and its impact on general well-being: a non-systematic review. Clin Interv Aging 2015; 10: 461-467.

  18. Patterson J, Willis A. Oral Medicine Considerations for Older Patients. Prim Dent J 2020; 9: 45-53.

  19. Tsifetaki N, Kitsos G, Paschides C A et al. Oral pilocarpine for the treatment of ocular symptoms in patients with Sjogren's syndrome: a randomised 12-week controlled study. Ann Rheum Dis 2003; 62: 1204-1207.

  20. Nayee S, Herbert C, Shirlaw P, Cook R. Dry mouth. Dent Update 2021; 48: 761-768.

  21. tLakraj A A, Moghimi N, Jabbari B. Sialorrhoea: anatomy, pathophysiology and treatment with emphasis on the role of botulinum toxins. Toxins (Basel) 2013; 5: 1010-1031.

  22. Willis A W, Roberts E, Beck J C et al. Incidence of Parkinson disease in North America. NPJ Parkinsons Dis 2022; 8: 170.

  23. National Institute for Health and Care Excellence. Xeomin (botulinum neurotoxin type A) for treating chronic sialorrhoea. 2019. Available at https://www.nice.org.uk/guidance/ta605 (accessed January 2024).

  24. Chen S, Lin Z, Chen J et al. Older age is a risk factor associated with poor prognosis of patients with squamous cell carcinoma of the oral cavity. Eur Arch Otorhinolaryngol 2020; 277: 2573-2580.

  25. Barrett T F, Mazul A L, Stepan K O et al. The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database. Oral Oncol 2021; 118: 105330.

  26. National Institute for Health and Care Excellence. Suspected cancer: recognition and referral. 2023. Available at https://www.nice.org.uk/guidance/ng12 (accessed January 2024).

  27. Lewis M A. Mouth cancer: presentation, detection and referral in primary dental care. Br Dent J 2018; 225: 833-840.

  28. Jinbu Y, Demitsu T. Oral ulcerations due to drug medications. Jpn Dent Sci Rev 2014; 50: 40-46.

  29. Bell A, Kasi A. Oral Mucositis. Treasure Island (FL): StatPearls Publishing, 2022.

  30. Bartlett D, O'Toole S. Tooth wear and aging. Aust Dent J 2019; 64: 59-62.

  31. BMJ Best Practice. Sialadenitis. 2023. Available at https://bestpractice.bmj.com/topics/en-gb/1038 (accessed January 2024).

  32. Parajuli R, Maharjan S. Tubercular Ulcer of Tongue in an Elderly Patient Masquerading as a Traumatic Ulcer. Case Rep Otolaryngol 2017; 2017: 8416963.

  33. Meurman J H, Hämäläinen P. Oral health and morbidity - implications of oral infections on the elderly. Gerodontology 2006; 23: 3-16.

  34. Thiyahuddin N M, Lamping E, Rich A M, Cannon R D. Yeast Species in the Oral Cavities of Older People: A Comparison between People Living in Their Own Homes and Those in Rest Homes. J Fungi (Basel) 2019; 5: 30.

  35. Warnakulasuriya S. White, red, and mixed lesions of oral mucosa: A clinicopathologic approach to diagnosis. Periodontology 2000 2019; 80: 89-104.

  36. Lorenzo-Pouso A I, Pérez-Jardón A, Caponio V C et al. Oral Chronic Hyperplastic Candidiasis and Its Potential Risk of Malignant Transformation: A Systematic Review and Prevalence Meta-Analysis. J Fungi (Basel) 2022; 8: 1093.

  37. Bandara H M, Samaranayake L P. Viral, bacterial, and fungal infections of the oral mucosa: Types, incidence, predisposing factors, diagnostic algorithms, and management. Periodontology 2000 2019; 80: 148-176.

  38. Sartawi S Y, Abu-Hammad S, Salim N A, Al-Omoush S. Denture Stomatitis Revisited: A Summary of Systematic Reviews in the Past Decade and Two Case Reports of Papillary Hyperplasia of Unusual Locations. Int J Dent 2021; 2021: 7338143.

  39. Martori E, Ayuso-Montero R, Martinez-Gomis J, Viñas M, Peraire M. Risk factors for denture-related oral mucosal lesions in a geriatric population. J Prosthet Dent 2014; 111: 273-279.

  40. Aydintuğ Y S, Bayar G R, Ozkan A, Günhan O, Musabak U. Thymoma with immunodeficiency with multiple recurrent oral herpetic infections. J Dent Sci 2016; 11: 103-106.

  41. Kalantzis A, Scully C. Oxford Specialist Handbook of Applied Medicine and Surgery in Dentistry. Oxford: Oxford University Press, 2012.

  42. Andrei E C, Baniță I M, Munteanu M C et al. Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity - An Update. Medicina (Kaunas) 2022; 58: 1103.

  43. Rotbeh A, Kazeminia M, Kalantari M, Rajati F. Global prevalence of oral pigmentation and its related factors: a systematic review and meta-analysis. J Stomatol Oral Maxillofac Surg 2022; 123: 411-424.

  44. Binmadi N O, Bawazir M, Alhindi N et al. Medication-Induced Oral Hyperpigmentation: A Systematic Review. Patient Prefer Adherence 2020; 14: 1961-1968.

  45. Felix D H, Luker J, Scully C. Oral medicine: 7. Red and pigmented lesions. Dent Update 2013; 40: 231-238.

  46. Voloshyna D, Al Barznji S, Shaik T A et al. Atorvastatin as a Rare Primary Cause of Drug-Induced Angioedema: A Case Report. Cureus 2022; 14: e28788.

  47. Lees T F, Bogdashich L, Godden D. Conserving resources in the diagnosis of intraoral fibroepithelial polyps. Br J Oral Maxillofac Surg 2021; 59: 9-12.

  48. Marshall M, Otero D, Niklander S, Martínez-Flores R. Cowden's syndrome diagnosed through oral lesions: A case report. J Clin Exp Dent 20211; 13: 1162-1166.

  49. Sarfi D, Konaté M, Adnane S, Elbouhairi M, Yahya I B. Intra oral lipoma: Report of 3 histologically different cases. Adv Oral Maxillofac Surg 2021 4: 100182.

  50. Linares M F, Leonel A C, Carvalho E J, de Castro J F, de Almeida O P, Perez D E. Intraoral lipomas: A clinicopathological study of 43 cases, including four cases of spindle cell/pleomorphic subtype. Med Oral Patol Oral Cir Bucal 2019; 24: 373-378.

  51. Bharath T S, Krishna Y R, Nalabolu G R, Pasupuleti S, Surapaneni S, Ganta S B. Neurofibroma of the palate. Case Rep Dent 2014; 2014: 898505.

  52. Badham N J. Blood blisters and the oesophageal cast. J Laryngol Otol 1967; 81: 791-803.

  53. De las Heras M E, Moreno R, Núñez M, Gómez M I, Ledo A. Angina bullosa haemorrhagica. J Dermatol 1996; 23: 507-509.

  54. Ordioni U, Hadj Saïd M, Thiery G, Campana F, Catherine J-H, Lan R. Angina bullosa haemorrhagica: a systematic review and proposal for diagnostic criteria. Int J Oral Maxillofac Surg 2019; 48: 28-39.

  55. Bustamante J G, Zaidi S R. Amyloidosis. Treasure Island (FL): StatPearls Publishing, 2023.

  56. Deng J, Chen Q, Ji P, Zeng X, Jin X. Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis. Oral Dis 2019; 25: 670-675.

  57. Yogarajah S, Setterfield J. Mouth ulcers and diseases of the oral cavity. Medicine 2021; 49: 407-413.

  58. Wong T, Yap T, Wiesenfeld D. Common causes of ‘swelling' in the oral cavity. Aust J Gen Pract 2020 49: 575-580.

  59. Parihar S, Garg R K, Narain P. Primary extra-nodal non-Hodgkin's lymphoma of gingiva: A diagnostic dilemma. J Oral Maxillofac Pathol 2013; 17: 320.

  60. Scully C, Bagán J V, Eveson J W, Barnard N, Turner F M. Sialosis: 35 cases of persistent parotid swelling from two countries. Br J Oral Maxillofac Surg 2008; 46: 468-472.

  61. Derafshi R, Rezazadeh F, Ghapanchi J, Basandeh Sharif D, Farzin M. Prevalence of Chronic Orofacial Pain in Elderly Patients Referred to Shiraz Dental School From 2005 to 2017. Anaesth Pain Med 2019; 9: e91182.

  62. Daumas A, Bichon A, Rioland C et al. Characteristics of giant cell arteritis patients under and over 75-years-old: A comparative study on 164 patients. Rev Med Interne 2019; 40: 278-285.

  63. Jang H Y, Kim J H, Song Y-K et al. Antidepressant Use and the Risk of Major Adverse Cardiovascular Events in Patients Without Known Cardiovascular Disease: A Retrospective Cohort Study. Front Pharmacol 2020; 11: 594474.

  64. World Health Organisation. Mental health of older adults. 2023. Available at https://www.who.int/news-room/fact-sheets/detail/mental-health-of-older-adults (accessed January 2024).

  65. Karamat A, Smith J G, Melek L N, Renton T. Psychologic Impact of Chronic Orofacial Pain: A Critical Review. J Oral Facial Pain Headache 2022; 36: 103-140.

  66. Fialová D, Topinková E, Gambassi G et al. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA 2005; 293: 1348-1358.

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Acknowledgments

The authors would like to acknowledge Professor Philip Lamey as well as the Medical Illustration Department at Belfast Health & Social Care Trust for the provision of clinical photographs.

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Conor O'Gorman and Amanda Willis both contributed equally to this article and accept responsibility for the entire content of the manuscript. Both authors approve its submission.

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Correspondence to Conor O’Gorman.

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O’Gorman, C., Willis, A. Oral medicine considerations for the older patient. Br Dent J 236, 251–260 (2024). https://doi.org/10.1038/s41415-024-7060-1

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