Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Clinical
  • Published:

The continuation of oral anticoagulation and antiplatelet therapy for dento-alveolar surgery: a service evaluation

Abstract

Background Patients taking oral anticoagulants (OACs) and oral antiplatelets (OAPs) have a risk of post-operative bleeding when dental extractions are required. Guidance exists to assist dental practitioners on how best to clinically manage these patients, but this is based upon low-quality evidence. The current service evaluation provides real world clinical data when these drugs are not discontinued for oral surgery procedures.

Materials and methods All OACs and OAPs were continued and patients requiring dental extractions had local haemostatic measures (local anaesthesia with adrenaline, socket packing with haemostat and resorbable sutures). All patients were offered a follow-up via a telephone clinic service after surgery to assess any post-operative bleeding.

Results A total of 439 patients underwent 513 surgical episodes, equating to 1,001 dental extractions. Overall, 412 (95.9%) patients reported no post-operative bleeding complications. A total of 18 (4.1%) patients reported post-operative bleeding requiring further intervention. All but two patients were managed with local haemostatic measures, and no patient required hospital admission. For the single novel OAC cohort of patients, 8/185 (4.3%) procedures had post-operative bleeding.

Conclusion This current service evaluation highlights that the risk of significant or life-threatening bleeding following dental extraction when OACs or OAPs are continued remains rare.

Key points

  • Highlights the low risk of significant or life-threatening bleeding following dental extractions in patients on oral anticoagulants or antiplatelets.

  • There was a higher percentage of post-operative bleeding from patients taking warfarin than those on direct oral anticoagulants.

  • Provides much-needed evidence on this subject, which is currently dictated by guidance acknowledging limited evidence.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ho K, van Hove M, Leng G. Trends in anticoagulant prescribing: a review of local policies in English primary care. BMC Health Serv Res 2020; 20: 279.

  2. Scottish Dental Clinical Effectiveness Programme. Management of Dental Patients Taking Anticoagulants or Antiplatelet Drugs - New guidance from SDCEP. 2015. Available at https://www.scottishdental.org/management-of-dental-patients-taking-anticoagulants-or-antiplatelet-drugs-new-guidance-from-sdcep/ (accessed August 2023).

  3. Scottish Dental Clinical Effectiveness Programme. Management of Dental Patients Taking Anticoagulant or Antiplatelet Drugs. 2015. Available at https://www.sdcep.org.uk/published-guidance/anticoagulants-and-antiplatelets/ (accessed August 2023).

  4. Wahl M J. Dental surgery in anticoagulated patients. Arch Intern Med 1998; 158: 1610-1616.

  5. Blacker D J, Wijdicks E F, McClelland R L. Stroke risk in anticoagulated patients with atrial fibrillation undergoing endoscopy. Neurology 2003; 61: 964-968.

  6. Yasaka M, Naritomi H, Minematsu K. Ischemic stroke associated with brief cessation of warfarin. Thromb Res 2006; 118: 290-293.

  7. Kitchen L, Erichson R B, Sideropoulos H. Effect of drug-induced platelet dysfunction on surgical bleeding. Am J Surg 1982; 143: 215-217.

  8. Cade J F, Hunt D, Stubbs K P, Gallus A S. Guidelines for the management of oral anticoagulant therapy in patients undergoing surgery. Med J Aust 1979; 2: 292-294.

  9. National Patient Safety Agency. Managing patients who are taking warfarin and undergoing dental treatment. Available at http://www.mfch.cz/wp-content/uploads/2017/04/NHS-antikoagulans.pdf (accessed December 2022).

  10. Woolcombe S A, Ball R E, Patel J P. Managing direct oral anticoagulants in accordance with the Scottish Dental Clinical Effectiveness Programme guidance for patients undergoing dentoalveolar surgery. Br Dent J 2022; 232: 547-554.

  11. Schwarb H, Tsakiris D A. New Direct Oral Anticoagulants (DOAC) and Their Use Today. Dent J (Basel) 2016; 4: 5.

  12. Hasan S S, Kow C S, Curley L E, Baines D L, Babar Z U. Economic evaluation of prescribing conventional and newer oral anticoagulants in older adults. Expert Rev Pharmacoecon Outcomes Res 2018; 18: 371-377.

  13. Davis C, Robertson C, Shivakumar S, Lee M. Implications of Dabigatran, a Direct Thrombin Inhibitor, for Oral Surgery Practice. J Can Dent Assoc 2013; 79: 74.

  14. Johansson K, Götrick B, Holst J, Tranæus S, Naimi-Akbar A. Impact of direct oral anticoagulants on bleeding tendency and postoperative complications in oral surgery: a systematic review of controlled studies. Oral Surg Oral Med Oral Pathol Oral Radiol 2023; 135: 333-346.

  15. Yang S, Shi Q, Liu J, Li J, Xu J. Should oral anticoagulant therapy be continued during dental extraction? A meta-analysis. BMC Oral Health 2016; 16: 81.

  16. Chahine J, Khoudary M, Nasr S. Anticoagulation Use prior to Common Dental Procedures: A Systematic Review. Cardiol Res Pract 2019; DOI: 10.1155/2019/9308631.

  17. Calcia T B, Oballe H J, de Oliveira Silva A M, Friedrich S A, Muniz F W. Is alteration in single drug anticoagulant/antiplatelet regimen necessary in patients who need minor oral surgery? A systematic review with meta-analysis. Clin Oral Investig 2021; 25: 3369-3381.

  18. Manfredi M, Dave B, Percudani D et al. World workshop on oral medicine VII: Direct anticoagulant agents management for invasive oral procedures: A systematic review and meta-analysis. Oral Dis 2019; 25: 157-173.

  19. European Medicines Agency. Annex I: Summary of Product Characteristics. Eliquis. Available at https://www.ema.europa.eu/en/documents/product-information/eliquis-epar-product-information_en.pdf (accessed November 2022).

  20. European Medicines Agency. Annex I: Summary of Product Characteristics. Xarelto. Available at https://www.ema.europa.eu/en/documents/product-information/xarelto-epar-product-information_en.pdf (accessed November 2022).

  21. Dodson T B. Managing anticoagulated patients requiring dental extractions: an exercise in evidence-based clinical practice. Evid Based Dent 2002; 3: 23-26.

  22. Kovich O, Otley C C. Thrombotic complications related to discontinuation of warfarin and aspirin therapy perioperatively for cutaneous operation. J Am Acad Dermatol 2003; 48: 233-237.

  23. Patel N, Patel V, Sarkar D, Nokes T, Blacklock P. Dual anti-platelet therapy and dento-alveolar surgery. How do we manage patients on anti-platelet medication? Br Dent J 2014; DOI: 10.1038/sj.bdj.2014.1055.

Download references

Acknowledgements

The authors would like to thank all clinical staff members in the oral surgery department at our hospital who kindly contributed towards this service evaluation.

Author information

Authors and Affiliations

Authors

Contributions

Conceptualisation (Vinod Patel, Christopher Sproat, Jerry Kwok, Kiran Beneng), data curation (Pradeep Sandhu, Serena Mayor), data analysis (Pradeep Sandhu), manuscript preparation (Pradeep Sandhu, Vinod Patel), manuscript review (Pradeep Sandhu, Vinod Patel, Christopher Sproat, Jerry Kwok, Kiran Beneng).

Corresponding author

Correspondence to Vinod Patel.

Ethics declarations

The authors declare no conflicts of interest.

Ethical approval was not applicable as this is a clinical service evaluation of current longstanding practice and not a research study. The service evaluation utilised psuedonymised data collection via dental records.

Data availability: not applicable.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sandhu, P., Mayor, S., Sproat, C. et al. The continuation of oral anticoagulation and antiplatelet therapy for dento-alveolar surgery: a service evaluation. Br Dent J 235, 313–318 (2023). https://doi.org/10.1038/s41415-023-6227-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41415-023-6227-5

This article is cited by

Search

Quick links