Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Clinical
  • Published:

The prosthodontic management of medication-related osteonecrosis of the jaw: a case report

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) has clear staging and management guidance from the American Association of Oral and Maxillofacial Surgeons. There is, however, less guidance on the prosthodontic rehabilitation for this cohort of patients. This paper aims to bring increased understanding on the staging of MRONJ as well as approaches to its prosthodontic management. This case report outlines a removable prosthodontic method that successfully rehabilitated a patient suffering from MRONJ. This case is well documented with the use of clinical photography. The article demonstrates techniques in overcoming the challenges of necrotic bone in the denture-bearing area, and how such methods can improve both tissue health and patient symptoms.

Key points

  • Provides an overview of the epidemiology of medication-related osteonecrosis of the jaw (MRONJ) and the latest staging criteria.

  • Highlights how removable prosthodontics can potentially reduce MRONJ's progression and arrest its symptoms.

  • Presents clear photographic documentation and description of the techniques used.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. NHS Education for Scotland and Scottish Dental Clinical Effectiveness Programme. Oral Health Management of Patients at Risk of Medication-related Osteonecrosis of the Jaw guidance. 2017. Available at https://www.sdcep.org.uk/wp-content/uploads/2017/04/SDCEP-Oral-Health-Management-of-Patients-at-Risk-of-MRONJ-Guidance-full.pdf (accessed November 2020).

  2. Ruggiero S L, Dodson T B, Fantasia J et al. American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw - 2014 update. J Oral Maxillofac Surg 2014; 72: 1938-1956.

  3. Saad F, Brown J E, Van Poznak C et al. Incidence, risk factors, and outcomes of osteonecrosis of the jaw: Integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol 2012; 23: 1341-1347.

  4. Otto S, Pautke C, Van den Wyngaert T et al. Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases. Cancer Treat Rev 2018; 69: 177-187.

  5. Troeltzsch M, Cagna D, Stähler P et al. Clinical features of peri-implant medication-related osteonecrosis of the jaw: Is there an association to peri-implantitis? J Craniomaxillofac Surg 2016; 44: 1945-1951.

  6. Khan A A, Morrison A, Hanley D A et al. Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. J Bone Miner Res 2015; 30: 3-23.

  7. Lesclous P, Abi Najm S, Carrel J P et al. Bisphosphonate-associated osteonecrosis of the jaw: A key role of inflammation? Bone 2009; 45: 843-852.

  8. Vahtsevanos K, Kyrgidis A, Verrou E et al. Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol 2009; 27: 5356-5362.

  9. Aghaloo T L, Tetradis S. Osteonecrosis of the Jaw in the Absence of Antiresorptive or Anti-angiogenic Exposure: A Series of 6 Cases. J Oral Maxillofac Surg 2017; 75: 129-142.

  10. Henien M, Carey B, Hullah E, Sproat C, Patel V. Methotrexate-associated osteonecrosis of the jaw: A report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol 2017; DOI: 10.1016/j.oooo.2017.09.005.

  11. FGDP (UK). Prophylactic Antimicrobials. 2014. Available online at https://www.fgdp.org.uk/antimicrobial-prescribing-standards/prophylactic-antimicrobials (accessed June 2020).

  12. von Wowern N. Correlation between the development of an oroantral fistula and the size of the corresponding bony defect. J Oral Surg 1973; 31: 98-102.

  13. Hasegawa T, Kawakita A, Ueda N et al. A multicentre retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ? Osteoporos Int 2017; 28: 2465-2473.

  14. Migliorati C A, Saunders D, Conlon M S et al. Assessing the association between bisphosphonate exposure and delayed mucosal healing after tooth extraction. J Am Dent Assoc 2013; 144: 406-414.

  15. Mozzati M, Arata V, Gallesio G, Carossa S. Tooth extraction and oral bisphosphonates: Comparison of different surgical protocols. Joint Bone Spine 2011; 78: 647-654.

  16. Hasegawa Y, Kawabe M, Kimura H, Kurita K, Fukuta J, Urade M. Influence of dentures in the initial occurrence site on the prognosis of bisphosphonate-related osteonecrosis of the jaws: A retrospective study. Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 114: 318-324.

  17. Göllner M, Holst S, Fenner M, Schmitt J. Prosthodontic treatment of a patient with bisphosphonate-induced osteonecrosis of the jaw using a removable dental prosthesis with a heat-polymerized resilient liner: A clinical report. J Prosthet Dent 2010; 103: 196-201.

  18. Leven A J, Preston A J. Conservative prosthetic rehabilitation of medication-related osteonecrosis of the jaw (MRONJ). Dent Update 2016; 43: 939-942.

  19. Schmidt W F, Smith D E. A six-year retrospective study of Molloplast -B -lined dentures. Part II: Liner serviceability. J Prosthet Dent 1983; 50: 459-465.

  20. Pinto J R R, Mesquita M F, Henriques G E P, de Arruda Nóbilo M A. Effect of thermocycling on bond strength and elasticity of 4 long-term soft denture liners. J Prosthet Dent 2002; 88: 516-521.

  21. Okita N, Ørstavik D, Ørstavik J, Ostby K. In vivo and in vitro studies on soft denture materials: microbial adhesion and tests for antibacterial activity. Dent Mater 1991; 7: 155-160.

  22. Patel V, Mansi J, Ghosh S et al. MRONJ risk of adjuvant bisphosphonates in early stage breast cancer. Br Dent J 2018; 224: 74-79.

Download references

Acknowledgements

The authors would like to thank the laboratory support from Leigh Davidson at Leeds Dental Institute and the patient who allowed the publication of this case.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas Dennis.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dennis, T., Gahan, M. The prosthodontic management of medication-related osteonecrosis of the jaw: a case report. Br Dent J 230, 23–26 (2021). https://doi.org/10.1038/s41415-020-2500-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41415-020-2500-z

Search

Quick links