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Cord blood is a suitable donor source of allogeneic hematopoietic cell transplantation for adult T-cell leukemia-lymphoma: a nationwide retrospective study

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Fig. 1: Transplantation outcoms after propensity score-matched analyses.

Data availability

The data of this study are not publicly available ethical restrictions that it exceeds the scope of the recipient/donor’s consent for research use in the registry. Data may be available from the corresponding author upon reasonable request and with permission of the JSTCT and the Japanese Data Center for Hematopoietic Cell Transplantation.

References

  1. Utsunomiya A, Miyazaki Y, Takatsuka Y, Hanada S, Uozumi K, Yashiki S, et al. Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transpl. 2001;27:15–20. https://doi.org/10.1038/sj.bmt.1702731.

    Article  CAS  Google Scholar 

  2. Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, et al. Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. J Clin Oncol. 2019;37:677–87. https://doi.org/10.1200/JCO.18.00501.

    Article  CAS  Google Scholar 

  3. Hishizawa M, Kanda J, Utsunomiya A, Taniguchi S, Eto T, Moriuchi Y, et al. Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood. 2010;116:1369–76. https://doi.org/10.1182/blood-2009-10-247510.

    Article  CAS  Google Scholar 

  4. Ishida T, Hishizawa M, Kato K, Tanosaki R, Fukuda T, Taniguchi S, et al. Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study. Blood. 2012;120:1734–41. https://doi.org/10.1182/blood-2012-03-414490.

    Article  CAS  Google Scholar 

  5. Kato K, Choi I, Wake A, Uike N, Taniguchi S, Moriuchi Y, et al. Treatment of patients with adult T cell leukemia/lymphoma with cord blood transplantation: a Japanese nationwide retrospective survey. Biol Blood Marrow Transpl. 2014;20:1968–74. https://doi.org/10.1016/j.bbmt.2014.08.012.

    Article  Google Scholar 

  6. Konuma T, Kanda J, Inamoto Y, Hayashi H, Kobayashi S, Uchida N, et al. Improvement of early mortality in single-unit cord blood transplantation for Japanese adults from 1998 to 2017. Am J Hematol. 2020;95:343–53. https://doi.org/10.1002/ajh.25705.

    Article  CAS  Google Scholar 

  7. Atsuta Y. Introduction of Transplant Registry Unified Management Program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data). Int J Hematol. 2016;103:3–10. https://doi.org/10.1007/s12185-015-1894-x.

    Article  Google Scholar 

  8. Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transpl. 2013;48:452–8. https://doi.org/10.1038/bmt.2012.244.

    Article  CAS  Google Scholar 

  9. Yoshimitsu M, Tanosaki R, Kato K, Ishida T, Choi I, Takatsuka Y, et al. Risk Assessment in Adult T Cell Leukemia/Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transpl. 2018;24:832–9. https://doi.org/10.1016/j.bbmt.2017.11.005.

    Article  Google Scholar 

  10. Fuchs EJ, O’Donnell PV, Eapen M, Logan B, Antin JH, Dawson P, et al. Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial. Blood. 2021;137:420–8. https://doi.org/10.1182/blood.2020007535.

    Article  CAS  Google Scholar 

  11. Tanaka T, Nakamae H, Ito A, Fuji S, Hirose A, Eto T, et al. A Phase I/II Multicenter Trial of HLA-Haploidentical PBSCT with PTCy for Aggressive Adult T Cell Leukemia/Lymphoma. Transplant Cell Ther. 2021;27:928 e921–928 e927. https://doi.org/10.1016/j.jtct.2021.07.010.

    Article  CAS  Google Scholar 

  12. Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, et al. Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study. Blood. 2021;138:1429–40. https://doi.org/10.1182/blood.2021011719.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank all the physicians and data managers at the institutions that contributed valuable data on HCT for ATL at JSTCT. We also thank all the members of the data management committees of the JSTCT. We thank Editage (www.editage.com) for English language editing. This work was supported, in part, by Practical Research Programs of the Japan Agency for Medical Research and Development (AMED) (22ck0106742h0001).

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MT, NN, SF, AW, AU, TF, MY, and KK participated in research design, data analyses, and writing of the paper. AI, TE, Toshio K, Yoshio M, Yukiyoshi M, Youko S, Yasuhiko M, NU, Yasushi S and KI participated in data collection and writing of the paper. JK, Takafumi K, TI, and YA participated in data management and writing of the paper.

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Correspondence to Masahito Tokunaga.

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Tokunaga, M., Nakano, N., Fuji, S. et al. Cord blood is a suitable donor source of allogeneic hematopoietic cell transplantation for adult T-cell leukemia-lymphoma: a nationwide retrospective study. Bone Marrow Transplant (2023). https://doi.org/10.1038/s41409-023-01919-3

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