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Long-term pulmonary function tests and complications following allogeneic stem cell transplantation

Bone Marrow Transplantation volume 56, pages 2299–2301 (2021)Cite this article

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To the Editor:

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) entails a high burden of treatment-related toxicity.

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References

  1. Solh M, Arat M, Cao Q, Majhail NS, Weisdorf D. Late-onset noninfectious pulmonary complications in adult allogeneic hematopoietic cell transplant recipients. Transplantation. 2011;91:798–803.

    Article  Google Scholar 

  2. Pagliuca S, Michonneau D, Sicre de Fontbrune F, Sutra Del Galy A, Xhaard A, Robin M, et al. Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. Blood Adv. 2019;3:2424–35.

    Article  Google Scholar 

  3. Yoshihara S, Yanik G, Cooke KR, Mineishi S. Bronchiolitis obliterans syndrome (BOS), bronchiolitis obliterans organizing pneumonia (BOOP), and other late-onset noninfectious pulmonary complications following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2007;13:749–59.

    Article  Google Scholar 

  4. Chien JW, Duncan S, Williams KM, Pavletic SZ. Bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplantation-an increasingly recognized manifestation of chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2010;16:S106–14.

    Article  Google Scholar 

  5. Couriel D, Carpenter PA, Cutler C, Bolanos-Maede J, Treister N, Gea-Banacloche J, et al. Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol Blood Marrow Transplant. 2006;12:375–96.

    Article  Google Scholar 

  6. Kwok WC, Liang BM, Lui MMS, Tam TCC, Sim JPY, Tse EWC, et al. Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome. Respirology. 2019;24:459–66.

    Article  Google Scholar 

  7. Hildebrandt GC, Fazekas T, Lawitschka A, Bertz H, Greinix H, Halter J, et al. Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD. Bone Marrow Transplant. 2011;46:1283–95.

    Article  CAS  Google Scholar 

  8. Quigg TC, Kim YJ, Goebel WS, Haut PR. Lung function before and after pediatric allogeneic hematopoietic stem cell transplantation: a predictive role for DLCOa/VA. J Pediatr Hematol Oncol. 2012;34:304–9.

    Article  Google Scholar 

  9. Jain NA, Pophali PA, Klotz JK, Ito S, Koklanaris E, Chawla K, et al. Repair of impaired pulmonary function is possible in very-long-term allogeneic stem cell transplantation survivors. Biol Blood Marrow Transplant. 2014;20:209–13.

    Article  Google Scholar 

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Acknowledgements

The authors wish to acknowledge with thanks the assistance of Sonia Kamenetsky in the preparation of this manuscript.

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Author notes

  1. These authors contributed equally: Eyal Fuchs, Emilia Hardak.

Authors and Affiliations

  1. Division of Pulmonary Medicine, Rambam Health Care Campus, Haifa, Israel

    Eyal Fuchs

  2. Division of Pulmonary Medicine, Bnai Zion Medical Center, Haifa, Israel

    Emilia Hardak

  3. Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

    Emilia Hardak & Tsila Zuckerman

  4. Department of Obstetrics-Gynecology, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel

    Or Lee Rak

  5. Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel

    Tsila Zuckerman

Authors
  1. Eyal Fuchs
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  2. Emilia Hardak
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  3. Or Lee Rak
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  4. Tsila Zuckerman
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Contributions

EF: writing—original draft, formal analysis, project administration, investigation, methodology, validation, writing—review and editing. EM: conceptualization, data curation, formal analysis, investigation, methodology, project administration, supervision, writing—review and editing. OLR: formal analysis, investigation, methodology, validation. TZ: conceptualization, project administration, supervision, writing—original draft, writing—review and editing.

Corresponding author

Correspondence to Eyal Fuchs.

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Fuchs, E., Hardak, E., Rak, O.L. et al. Long-term pulmonary function tests and complications following allogeneic stem cell transplantation. Bone Marrow Transplant 56, 2299–2301 (2021). https://doi.org/10.1038/s41409-021-01376-w

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  • DOI: https://doi.org/10.1038/s41409-021-01376-w

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