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HHV-6 associated diseases are one of the major factors on higher early CNS complications in CB recipients than in those of BM/PBSC

Bone Marrow Transplantation volume 56, pages 686–688 (2021)Cite this article

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Central nervous system (CNS) complications that occur after allogeneic stem cell transplantation (allo-SCT) are one of the life-threatening events [1,2,3,4,5]. Previous studies reported that the incidence of early CNS complications (ECNSCs) is ~20% in allo-SCT. Recently, human herpes virus 6 (HHV-6)-associated CNS disorder (HHV-6-AD) was reported to occur frequently after cord blood transplantation (CBT) [2]. There have been several publications investigating CNS complications after allo-SCT, but only small population of CB recipients were included [1, 2, 5]. Therefore, the medical records of 723 consecutive patients including 430 CB recipients who underwent first allo-SCT at our institution were reviewed retrospectively. The main objectives of this study were to describe the incidence and etiologies of ECNSCs, and to identify risk factors for ECNSCs in a large population of allo-SCT recipients.

The medical records of 723 patients who underwent first allo-SCT at Toranomon Hospital between January 2006 and December 2013 were analyzed. ECNSCs were defined as distinct CNS manifestations such as convulsions, impaired consciousness, short-term memory deficits, or focal symptoms occurring within 100 days post-transplant. CNS relapses of underlying diseases were excluded. This study was approved by the institutional review board.

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Authors and Affiliations

  1. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    Kosei Kageyama, Naoyuki Uchida, Hisashi Yamamoto, Shinsuke Takagi, Michiho Ebihara, Mitsuhiro Yuasa, Daisuke Kaji, Aya Nishida, Go Yamamoto, Yuki Asano-Mori, Koji Izutsu & Shuichi Taniguchi

  2. Department of Hematology, Toranomon Hospital Kajigaya, Kanagawa, Japan

    Kazuya Ishiwata & Atsushi Wake

  3. Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan

    Akiko Yoneyama

  4. Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan

    Shigeyoshi Makino

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  1. Kosei Kageyama
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Correspondence to Naoyuki Uchida.

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Kageyama, K., Uchida, N., Yamamoto, H. et al. HHV-6 associated diseases are one of the major factors on higher early CNS complications in CB recipients than in those of BM/PBSC. Bone Marrow Transplant 56, 686–688 (2021). https://doi.org/10.1038/s41409-020-01028-5

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