The role of interim-foscarnet prophylaxis in preventing cytomegalovirus infection after ex vivo αβ T cell-depleted haploidentical hematopoietic cell transplant in children

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Fig. 1: Cumulative incidence of CMV reactivation according to prophylaxis group.

References

  1. 1.

    Teira P, Battiwalla M, Ramanathan M, Barrett AJ, Ahn KW, Chen M, et al. Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis. Blood. 2016;127:2427–38. https://doi.org/10.1182/blood-2015-11-679639.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Laberko A, Bogoyavlenskaya A, Shelikhova L, Shekhovtsova Z, Balashov D, Voronin K, et al. Risk factors for and the clinical impact of cytomegalovirus and Epstein-Barr virus infections in pediatric recipients of TCR-alpha/beta- and CD19-depleted grafts. Biol Blood Marrow Transpl. 2017;23:483–90. https://doi.org/10.1016/j.bbmt.2016.12.635.

    Article  Google Scholar 

  3. 3.

    Boeckh M, Ljungman P. How we treat cytomegalovirus in hematopoietic cell transplant recipients. Blood. 2009;113:5711–9. https://doi.org/10.1182/blood-2008-10-143560.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Hammerstrom AE, Lombardi LR, Pingali SR, Rondon G, Chen J, Milton DR, et al. Prevention of cytomegalovirus reactivation in haploidentical stem cell transplantation. Biol Blood Marrow Transpl. 2018;24:353–8. https://doi.org/10.1016/j.bbmt.2017.09.018.

    CAS  Article  Google Scholar 

  5. 5.

    Milano F, Pergam SA, Xie H, Leisenring WM, Gutman JA, Riffkin I, et al. Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients. Blood. 2011;118:5689–96. https://doi.org/10.1182/blood-2011-06-361618.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Im HJ, Koh KN, Suh JK, Lee SW, Choi ES, Jang S, et al. Haploidentical HCT using an alphabeta T-cell-depleted graft with targeted alphabeta(+) cells by add-back after a reduced intensity preparative regimen containing low-dose TBI. Bone Marrow Transpl. 2016;51:1217–22. https://doi.org/10.1038/bmt.2016.114.

    CAS  Article  Google Scholar 

  7. 7.

    Ljungman P, Boeckh M, Hirsch HH, Josephson F, Lundgren J, Nichols G, et al. Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials. Clin Infect Dis. 2017;64:87–91. https://doi.org/10.1093/cid/ciw668.

    Article  PubMed  Google Scholar 

  8. 8.

    Stern L, Withers B, Avdic S, Gottlieb D, Abendroth A, Blyth E, et al. Human cytomegalovirus latency and reactivation in allogeneic hematopoietic stem cell transplant recipients. Front Microbiol. 2019;10:1186. https://doi.org/10.3389/fmicb.2019.01186.

    Article  PubMed  PubMed Central  Google Scholar 

  9. 9.

    Slobedman B, Mocarski ES. Quantitative analysis of latent human cytomegalovirus. J Virol. 1999;73:4806–12.

    CAS  Article  Google Scholar 

  10. 10.

    Goodrum F, Jordan CT, Terhune SS, High K, Shenk T. Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. Blood. 2004;104:687–95.

    CAS  Article  Google Scholar 

  11. 11.

    Doherty PC, Allan W, Eichelberger M, Carding SR. Roles of alpha beta and gamma delta T cell subsets in viral immunity. Annu Rev Immunol. 1992;10:123–51. https://doi.org/10.1146/annurev.iy.10.040192.001011.

    CAS  Article  PubMed  Google Scholar 

  12. 12.

    Xia C-Q, Chernatynskaya AV, Wasserfall CH, Wan S, Looney BM, Eisenbeis S, et al. Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice. BMC Immunol. 2012;13:70. https://doi.org/10.1186/1471-2172-13-70.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Ho Joon Im.

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Kang, S.H., Yoo, J.W., Seo, J.K. et al. The role of interim-foscarnet prophylaxis in preventing cytomegalovirus infection after ex vivo αβ T cell-depleted haploidentical hematopoietic cell transplant in children. Bone Marrow Transplant (2020). https://doi.org/10.1038/s41409-020-01020-z

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