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The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT

Bone Marrow Transplantation volume 54, pages 721–726 (2019)Cite this article

Abstract

One of the remaining and unresolved problems in allogeneic stem cell transplantation, especially following a T cell-depleted transplant as often performed in the setting of haploidentical transplantation, is the relapse of the underlying hematological malignancy. It has been demonstrated that in the last years we have made major progress in controlling infections, acute and chronic GvHD and making stem cell transplantation available to elderly patients. However, little improvement has been made to achieve better tumor control and to lower the relapse rate. Thus, novel immunotherapeutic strategies are increasingly used prior to or even following allogeneic stem cell transplantation to better control the underlying malignancy and thus, to reduce the relapse rate. These novel immunotherapeutic strategies comprise monoclonal antibodies, immunotoxins and even more effective T cell redirecting strategies like bispecific antibodies and T cells transduced with either chimeric antigen receptors (CAR) or (affinity-tuned) T cell receptors (TCR).

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Funding

Publication of this supplement was sponsored by Gilead Sciences Europe Ltd, Cell Source, Inc. The Chorafas Institute for Scientific Exchange of the Weizmann Institute of Science, Kiadis Pharma, Miltenyi Biotec, Celgene, Centro Servizi Congressuali, Almog Diagnostic.

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Authors and Affiliations

  1. Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany

    Hermann Einsele, Leo Rasche, Max S. Topp, K. Martin Kortüm & Johannes Duell

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  1. Hermann Einsele
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  2. Leo Rasche
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  3. Max S. Topp
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  4. K. Martin Kortüm
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  5. Johannes Duell
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Correspondence to Hermann Einsele.

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Conflict of interest

LR has received consulting fees from Pfizer and grant support from DFG. HE has received consulting fees, grants, and honoraria from Amgen, Celgene, Janssen, and BMS. KMK has received consulting fees from Janssen, and Oncopeptide. MST received lecture fees from Amgen, Regeneron, Roche, and lecture fees from Amgen. JD received consulting fees from Gilead.

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Einsele, H., Rasche, L., Topp, M.S. et al. The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT. Bone Marrow Transplant 54 (Suppl 2), 721–726 (2019). https://doi.org/10.1038/s41409-019-0596-z

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