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Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Bone Marrow Transplantation volume 54, pages 798–809 (2019)Cite this article

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Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission is a standard of care for adult patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) and high risk of relapse. However, the stratification systems vary among study groups. Inadequate response at the level of minimal residual disease is the most commonly accepted factor indicating the need for alloHSCT. In this consensus paper on behalf of the European Working Group for Adult Acute Lymphoblastic Leukemia and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize available evidence and reflect current clinical practice in major European study groups regarding both indications for HSCT and particular aspects of the procedure including the choice of donor, source of stem cells and conditioning. Finally, we propose recommendations for daily clinical practice as well as for planning of prospective trials.

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Authors and Affiliations

  1. Maria Sklodowska-Curie Institute–Cancer Center, Gliwice Branch, Gliwice, Poland

    Sebastian Giebel & Nicola Gökbuget

  2. University Hospitals Bristol National Health Service Foundation Trust, Bristol, UK

    David I. Marks

  3. Hopital St. Louis, Paris, France

    Nicolas Boissel, Nicola Gökbuget & Hervé Dombret

  4. CHU Sart-Tilman, University of Liege, Liege, Belgium

    Frederic Baron

  5. Sapienza University, Rome, Italy

    Sabina Chiaretti & Robin Foa

  6. San Raffaele Scientific Institute, Milan, Italy

    Fabio Ciceri

  7. Erasmus MC Cancer Institute University Medical Center, Rotterdam, The Netherlands

    Jan J. Cornelissen & Anita W. Rijneveld

  8. University Hospital, Brno, Czechia

    Michael Doubek

  9. IDIBAPS, Hospital Clinic, Barcelona, Spain

    Jordi Esteve

  10. North London Cancer Network, Univ. College London Hosp, London, UK

    Adele Fielding, Mohamad Mohty & Arnon Nagler

  11. EBMT Acute Leukemia Working Party Office, Paris, France

    Norbert-Claude Gorin & Mohamad Mohty

  12. Hospital Saint-Antoine, Paris, France

    Norbert-Claude Gorin

  13. Uppsala University, Uppsala, Sweden

    Helene Hallböök

  14. University Hospital, Goethe University, Frankfurt, Germany

    Dieter Hoelzer

  15. FGBU Hematology Research Center, Russia Federation Ministry of Public Health, Moscow, Russia

    Elena Paravichnikova

  16. ICO-Hospital Germans Trias I Pujol, Jose Carreras Research Institute, Badalona, Spain

    Josep-Maria Ribera

  17. Vanderbilt University Medical Center, Nashville, USA

    Bipin Savani

  18. Klinikum Augsburg, Ludwig-Maximilians-Universitaet, Munich–Augsburg, Germany

    Christoph Schmid

  19. Helsinki University Hospital, Helsinki, Finland

    Ulla Wartiovaara-Kautto

  20. Chaim Sheba Medical Center, Tel-Hashomer, Israel

    Arnon Nagler

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  1. Sebastian Giebel
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Giebel, S., Marks, D.I., Boissel, N. et al. Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 54, 798–809 (2019). https://doi.org/10.1038/s41409-018-0373-4

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