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Haploidentical versus matched donor stem cell transplantation for patients with hematological malignancies: a systemic review and meta-analysis

Bone Marrow Transplantation volume 54, pages 99–122 (2019)Cite this article

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Abstract

We compared the safety and efficacy of haploidentical stem cell transplantation (haplo-SCT) to matched donor SCT (matched-SCT) in treating hematological malignancies. The Medline, Cochrane, EMBASE, and Google Scholar databases were searched through 21 June 2017 using the search term “(hematological disease) AND matched AND (haploidentical OR haplo-identical OR haplo identical OR haplo transplantation OR haplo transplant OR haplo-SCT OR haplo-HSCT OR haplo-HCT).” Twenty-five studies enrolling 11,359 patients (haplo-SCT: 2677; matched-SCT: 8682) were included. The primary outcomes were acute and chronic graft-versus-host disease (GVHD), non-relapse mortality, and 1-year cumulative incidence of relapse. Haplo-SCT was associated with similar risks as matched-SCT for all primary endpoints. Subgroup analysis of patients who received a matched-SCT from a related donor revealed that patients who received haplo-SCT had a lower risk of acute GVHD. Among patients who received reduced-intensity conditioning (RIC), those who received haplo-SCT had a higher risk of acute grade II–IV GVHD and non-relapse mortality than did patients who received a matched-SCT from a related or unrelated donor. Haplo-SCT should continue to be considered as a safe and effective transplant option when a matched donor is unavailable, but it may not be suitable for patients who receive RIC.

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Funding

This study was supported by the National Natural Science Foundation of China (no. 81273597, no. 81302801), Clinical Support Foundation of Chinese PLA General Hospital (no. 2016FC-ZHCG-1004), the Innovation and Nursery Foundation of Chinese PLA General Hospital (no. 15KMM21), and the Capital Characteristic Key Project of Beijing Municipal Science and Technology Commission (no. Z161100000516006).

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  1. These authors contributed equally: Bo Yang, Ruili Yu, Lili Cai.

Authors and Affiliations

  1. Department of Hematology, Nanlou Division & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China

    Bo Yang, Hongfei Chen & Xuechun Lu

  2. Department of Allergy, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038, China

    Ruili Yu

  3. Department of Laboratory Medicine, Nanlou Division & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China

    Lili Cai

  4. Department of Library and Information Science, Shanxi Medical University School of Management, Taiyuan, 30001, China

    Bin Guo

  5. Department of Respiratory Disease, Nanlou Division & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China

    Hongfei Chen

  6. Department of Social Medicine and Health Service Management, Shanxi Medical University School of Management, Taiyuan, 30001, China

    Haomin Zhang & Peifeng He

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Yang, B., Yu, R., Cai, L. et al. Haploidentical versus matched donor stem cell transplantation for patients with hematological malignancies: a systemic review and meta-analysis. Bone Marrow Transplant 54, 99–122 (2019). https://doi.org/10.1038/s41409-018-0239-9

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