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Iodine staining and p16 immunohistochemistry as a novel screening for secondary esophageal neoplasm after hematopoietic stem cell transplantation

Bone Marrow Transplantation 53, 1359–1363 (2018) | Download Citation

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References

  1. 1.

    Atsuta Y, Suzuki R, Yamashita T, Fukuda T, Miyamura K, Taniguchi S, et al. Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease. Ann Oncol. 2014;25:435–41.

  2. 2.

    Rizzo JD, Curtis RE, Socie G, Sobocinski KA, Gilbert E, Landgren O, et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood. 2009;113:1175–83.

  3. 3.

    Kolb HJ, Socie G, Duell T, Van Lint MT, Tichelli A, Apperley JF, et al. Malignant neoplasms in long-term survivors of bone marrow transplantation. Late Effects Working Party of the European Cooperative Group for Blood and Marrow Transplantation and the European Late Effect Project Group. Ann Intern Med. 1999;131:738–44.

  4. 4.

    Kakei Y, Akashi M, Komatsubara H, Minamikawa T, Komori T. p16 overexpression in malignant and premalignant lesions of the oral and esophageal mucosa following allogeneic hematopoietic stem cell transplantation. Head Neck Oncol. 2012;4:38.

  5. 5.

    Katz J, Islam MN, Bhattacharyya I, Sandow P, Moreb JS. Oral squamous cell carcinoma positive for p16/human papilloma virus in post allogeneic stem cell transplantation: 2 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e74–8.

  6. 6.

    Curtis RE, Metayer C, Rizzo JD, Socie G, Sobocinski KA, Flowers ME, et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood. 2005;105:3802–11.

  7. 7.

    Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007;370:59–67.

  8. 8.

    Bucchi D, Stracci F, Buonora N, Masanotti G. Human papillomavirus and gastrointestinal cancer: a review. World J Gastroenterol. 2016;22:7415–30.

  9. 9.

    Mulvany NJ, Allen DG, Wilson SM. Diagnostic utility of p16INK4a: a reappraisal of its use in cervical biopsies. Pathology. 2008;40:335–44.

  10. 10.

    Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48:452–8.

  11. 11.

    Tachimori Y, Ozawa S, Numasaki H, Ishihara R, Matsubara H, Muro K, et al. Comprehensive registry of esophageal cancer in Japan, 2010. Esophagus. 2017;14:189–214.

  12. 12.

    Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C, et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012;18:348–71.

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Acknowledgements

The authors thank all the patients who consented to participate in this study.

Author contribution

AS, KM, and MI designed and launched the study; TS, AS, YK, NK, and DK collected data; TS and AS analyzed results and wrote the manuscript; MI evaluated biopsy samples; all authors contributed to discussion; YO, KM, TY, JH, and IM supervised the study and revised the manuscript.

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Affiliations

  1. Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    • Takahiko Sato
    • , Aika Seto
    • , Yusuke Kagaya
    • , Naomi Kawashima
    • , Daisuke Koyama
    • , Takanobu Morishita
    • , Yukiyasu Ozawa
    •  & Koichi Miyamura

  2. Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    • Takeo Yamaguchi
    •  & Jun-ichi Haruta

  3. Department of Pathology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    • Masafumi Ito

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Masafumi Ito.

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DOI

https://doi.org/10.1038/s41409-018-0197-2