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Validated prognostic significance of YB-1 genetic variation in metastatic prostate cancer

The Pharmacogenomics Journal volume 21, pages 102–105 (2021)Cite this article

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Abstract

Genetic polymorphism in YB-1 was previously shown to be associated with the prognosis of advanced prostate cancer patients treated with primary androgen-deprivation therapy. However, the significance of this polymorphism remains invalidated. In this study, we aimed to validate the prognostic significance of the YB-1 genetic polymorphism in metastatic prostate cancer. This study included 79 Japanese patients who were diagnosed as metastatic prostate cancer between 2000 and 2016. Genomic DNA was obtained from patient whole blood samples, and genotyping on YB-1 (rs12030724) was performed by PCR-based technique. The association of genotype in YB-1 with clinicopathological parameters and oncological outcome, including progression-free survival and overall survival, was examined. Homozygous wild-type (AA), heterozygous variant (AT), and homozygous variant (TT) were identified in 47 (59.5%), 26 (32.9%) and 6 patients (7.6%), respectively. Heterozygous/homozygous variant (AT/TT) in YB-1 was significantly associated with lower progression risk compared with homozygous wild-type (AA) (hazard ratio = 0.52; 95% confidence interval = 0.30–0.88, P = 0.015). Consistent with this finding, heterozygous/homozygous variant (AT/TT) in YB-1 was significantly associated with lower risk of any-cause mortality compared with homozygous wild-type (AA) (hazard ratio = 0.46; 95% confidence interval = 0.21–0.93, P = 0.031). Gene polymorphism in YB-1 rs12030724 was validated to be a promising predictive biomarker of androgen-deprivation therapy in metastatic prostate cancer to identify patients requiring more intensive therapeutics.

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Fig. 1: Gene polymorphism in YB-1 rs12030724 correlates with prognosis in metastatic prostate cancer patients.

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Acknowledgements

We thank Edanz Group (www.edanzediting.com/ac) for editing a draft of this paper. This work was supported by a JSPS KAKENHI grant [17K11145].

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  1. These authors contributed equally: Masaki Shiota, Shintaro Narita

Authors and Affiliations

  1. Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan

    Masaki Shiota & Masatoshi Eto

  2. Department of Urology, Graduate School of Medicine, Akita University, Akita, 010-8543, Japan

    Shintaro Narita & Tomonori Habuchi

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  1. Masaki Shiota
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Correspondence to Masaki Shiota.

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Shiota, M., Narita, S., Habuchi, T. et al. Validated prognostic significance of YB-1 genetic variation in metastatic prostate cancer. Pharmacogenomics J 21, 102–105 (2021). https://doi.org/10.1038/s41397-020-00188-3

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