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Organophosphorus poisoning induced delayed neurotoxicity: a report of two cases

Spinal Cord Series and Cases volume 9, Article number: 54 (2023) Cite this article

Subjects

Abstract

Introduction

Organophosphorus compounds (OPC) are one of the most commonly used pesticides worldwide and are often misused for suicidal poisoning due to their easy availability. Acute manifestations and management of organophosphorus (OP) poisoning have been reported several times. Organophosphorus-induced delayed neurotoxicity (OPIDN) is a rare delayed presentation of OP poisoning that involves central-peripheral distal axonopathy.

Case presentation

In this study, we report two cases of OPIDN developed after a few weeks of OP poisoning. Clinical features, electrodiagnostic study findings, and rehabilitative measures adopted for the patients and their follow-up have been described in the report.

Discussion

Organophosphorus (OP) poisoning may rarely produce features of delayed neurotoxicity, which may gradually appear after acute cholinergic symptoms. This report shows the importance of considering the delayed presentation of possible OPC toxicity in patients with neurological symptoms and a history of OPC exposure.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, Bhubaneswar, India

    Amrutha Viswanath, Apurba Barman, Jagannatha Sahoo, Souvik Bhattacharjee & Suman Patel

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  1. Amrutha Viswanath
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  2. Apurba Barman
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All authors participated in drafting of the paper, and critical revision of the article. All authors approved the final version of the article.

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Correspondence to Amrutha Viswanath.

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Viswanath, A., Barman, A., Sahoo, J. et al. Organophosphorus poisoning induced delayed neurotoxicity: a report of two cases. Spinal Cord Ser Cases 9, 54 (2023). https://doi.org/10.1038/s41394-023-00611-4

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