Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Differentiating essential hypertension from autonomic dysreflexia: a case report

Abstract

Introduction

Autonomic dysreflexia (AD), a condition of critically raised blood pressure, is a severe complication of spinal cord injury. Primary (essential) hypertension may present with similar blood pressure levels to AD, though the causes, pathophysiology, presentation and treatment will differ.

Case presentation

We report a case of a 74-year-old patient with a C1 spinal injury, who developed primary (essential) hypertension during her rehabilitation phase of care, requiring extensive investigations for autonomic dysreflexia. Despite this, no underlying cause was found; essential hypertension was subsequently confirmed with 24-hour ambulatory blood pressure monitoring. Treatment with an ACE inhibitor was introduced to good effect.

Discussion

Essential hypertension can affect patients with spinal injury, even though most patients with higher level injuries (particularly cervical spinal cord injuries) are expected to have low resting baseline hypotension. Relevant features of this are presented within this case; a set of criteria to differentiate essential hypertension from autonomic dysreflexia are also proposed.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Ambulatory BP readings, showing BP and heart rate over a 24-hour period.

Similar content being viewed by others

Data availability

Patient data is retained by Royal Rehab and is not available for release due to legislative requirements regarding patient privacy.

References

  1. American Spinal Injury Association. International Standards for Neurological Classification of Spinal Cord Injury. Richmond, VA: American Spinal Injury Association; 2019.

  2. Ditunno JF, Donovan WH, Oleson CV, Goshgarian HG, Kim RC, Perez-Rosendahl M, et al. Spinal Cord Medicine [Internet]. 3rd ed. Kirshblum SL, Vernon W, editor. New York: Springer Publishing Company; Available from: https://connect.springerpub.com/content/book/978-0-8261-3775-3.

  3. Eldahan KC, Rabchevsky AG. Autonomic dysreflexia after spinal cord injury: systemic pathophysiology and methods of management. Auton Neurosci Basic Clin. 2018;209:59–70.

    Article  Google Scholar 

  4. Krassioukov A, Linsenmeyer TA, Beck LA, Elliott S, Gorman P, Kirshblum S, et al. Evaluation and management of autonomic dysreflexia and other autonomic dysfunctions: preventing the highs and lows. Top Spinal Cord Inj Rehabil. 2021;27:225–90.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Milligan J, Lee J, McMillan C, Klassen H. Autonomic dysreflexia: recognizing a common serious condition in patients with spinal cord injury. Can Fam Physician. 2012 ;58:831–5.

    PubMed  PubMed Central  Google Scholar 

  6. McLean AN. The spinal cord-injured patient in the medical ward. Clin Med. 2013;13:549–52.

    Article  Google Scholar 

  7. Barry W, St Andre JR, Evans CT, Sabharwal S, Miskevics S, Weaver FM, et al. Hypertension and antihypertensive treatment in veterans with spinal cord injury and disorders. Spinal Cord. 2013;51:109–15.

    Article  CAS  PubMed  Google Scholar 

  8. Krassioukov A, Warburton DE, Teasell R, Eng JJ. A systematic review of the management of autonomic dysreflexia following spinal cord injury. Arch Phys Med Rehabil. 2009;90:682–95.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Hubli M, Krassioukov AV. Ambulatory blood pressure monitoring in spinal cord injury: clinical practicability. J Neurotrauma. 2014;31:789–97.

    Article  PubMed  PubMed Central  Google Scholar 

  10. West CR, Bellantoni A, Krassioukov AV. Cardiovascular function in individuals with incomplete spinal cord injury: a systematic review. Top Spinal Cord Inj Rehabil. 2013;19:267–78.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Funding

No external funding was received for the production of this manuscript. LS and GW are both employees of Royal Rehab, which was not involved in the creation, content or decision to publish this manuscript.

Author information

Authors and Affiliations

Authors

Contributions

LS and GW were both involved in the patient’s clinical care. LS authored the initial manuscript and GW provided review and comments.

Corresponding author

Correspondence to Leon Smith.

Ethics declarations

Competing interests

The author declare no competing interests.

Informed consent

Informed consent was provided by the patient’s next of kin (acting as her person responsible) for publication of this case.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smith, L., Weber, G. Differentiating essential hypertension from autonomic dysreflexia: a case report. Spinal Cord Ser Cases 9, 51 (2023). https://doi.org/10.1038/s41394-023-00607-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41394-023-00607-0

Search

Quick links