Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Clinical

Does Retzius-Sparing robot-assisted radical prostatectomy guarantee optimal urinary continence recovery across all ages?

Prostate Cancer and Prostatic Diseases (2024)Cite this article

Subjects

Abstract

The association between age at surgery and urinary continence (UC) recovery after Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) is not well established. We addressed this knowledge gap, relying on a large series of 1,417 patients treated with RS-RARP at a high-volume centre between 2010 and 2021. Multivariable logistic models, as well as LOESS plot functions were performed. The probability of immediate, as well as 12-month UC-recovery progressively declined with increasing age at surgery, and per 5-years age at surgery increase reached the independent predictor status for both immediate and 12-month UC-recovery. These findings may significantly improve the quality of patient counseling regarding RS-RARP.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Graphical depiction of the multivariable logistic regression-derived relationship between age at surgery and probability of immediate, as well as 12-month urinary continence recovery.

Similar content being viewed by others

References

  1. Mottet N, Cornford P, van den Bergh RCN, Briers E, De Santis M, Gillessen S, et al. EAU - EANM - ESTRO - ESUR - ISUP - SIOG Guidelines on Prostate Cancer 2022. Eur. Assoc. Urol. Guidel. 2022.

  2. Checcucci E, Veccia A, Fiori C, Amparore D, Manfredi M, Di Dio M, et al. Retzius-sparing robot-assisted radical prostatectomy vs the standard approach: a systematic review and analysis of comparative outcomes. BJU Int. 2020;125:8–16.

    Article  PubMed  Google Scholar 

  3. Rosenberg JE, Jung JH, Edgerton Z, Lee H, Lee S, Bakker CJ, et al. Retzius-sparing versus standard robotic-assisted laparoscopic prostatectomy for the treatment of clinically localized prostate cancer. Cochrane Datab Syst Rev. 2020;2020. https://doi.org/10.1002/14651858.CD013641.pub2.

  4. Dell’Oglio P, Tappero S, Longoni M, Buratto C, Scilipoti P, Secco S, et al. Retzius-sparing robot-assisted radical prostatectomy in high-risk prostate cancer patients: results from a large single-institution series. Eur Urol Open Sci. 2022;38:69–78.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Mandel P, Graefen M, Michl U, Huland H, Tilki D. The effect of age on functional outcomes after radical prostatectomy. Urol Oncol. 2015;33:203.e11–203.e18.

    Article  PubMed  Google Scholar 

  6. Gondoputro W, Thompson J, Evans M, Bolton D, Frydenberg M, Murphy DG, et al. How does age affect urinary continence following robot-assisted radical prostatectomy? a prospective multi-institutional study using independently collected, validated questionnaires. J Urol. 2022;207:1048–56.

    Article  PubMed  Google Scholar 

  7. Traboulsi SL, Nguyen DD, Zakaria AS, Law KW, Shahine H, Meskawi M, et al. Functional and perioperative outcomes in elderly men after robotic-assisted radical prostatectomy for prostate cancer. World J Urol. 2020;38:2791–8.

    Article  CAS  PubMed  Google Scholar 

  8. Assel M, Sjoberg D, Elders A, Wang X, Huo D, Botchway A, et al. Guidelines for reporting of statistics for clinical research in urology. Eur Urol. 2019;75:358–67.

    Article  PubMed  Google Scholar 

  9. Tappero S, Dell’Oglio P, Longoni M, Buratto C, Palagonia E, Scilipoti P, et al. Challenging cases in high-risk prostate cancer patients treated with Retzius-sparing robot-assisted radical prostatectomy. World J Urol. 2022;40:1993–9.

    Article  PubMed  Google Scholar 

  10. Tappero S, Vecchio E, Palagonia E, Longoni M, Martiriggiano M, Granelli G, et al. Retzius-sparing robot-assisted radical prostatectomy after previous trans-urethral resection of the prostate: Assessment of functional and oncological outcomes. Eur J Surg Oncol. 2023. https://doi.org/10.1016/j.ejso.2023.03.218.

Download references

Acknowledgements

The authors have no acknowledgments. The research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Author information

Authors and Affiliations

  1. Department of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy

    Paolo Dell’Oglio, Ofir Maltzman, Alberto Olivero, Silvia Secco, Dario Di Trapani, Aldo Massimo Bocciardi & Antonio Galfano

  2. Department of Urology, Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Paolo Dell’Oglio

  3. Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

    Paolo Dell’Oglio

  4. Ospedale Policlinico San Martino, Genova, Italy

    Stefano Tappero

  5. Department of Surgical and Diagnostic Integrated Sciences (DISC), University of Genova, Genova, Italy

    Stefano Tappero

Authors
  1. Paolo Dell’Oglio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefano Tappero
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ofir Maltzman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alberto Olivero
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Silvia Secco
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Dario Di Trapani
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Aldo Massimo Bocciardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Antonio Galfano
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Study concept and design: PD, ST. Acquisition of data: PD, OM, SS, AO, DDT. Analysis and interpretation of data: PD, ST. Drafting of the manuscript: PD, ST. Critical revision of the manuscript for important intellectual content: AMB, AG. Statistical analysis: ST. Obtaining funding: none. Supervision: AG, AMB.

Corresponding author

Correspondence to Paolo Dell’Oglio.

Ethics declarations

Competing interests

The authors declare no cometing interests.

Ethics consent

Due to the anonymously coded design of the exploited database, study-specific Institutional Review Board ethics approval was not required.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Patient consent statement, permission to reproduce material from other sources and clinical trial registration Not applicable.

Supplementary information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dell’Oglio, P., Tappero, S., Maltzman, O. et al. Does Retzius-Sparing robot-assisted radical prostatectomy guarantee optimal urinary continence recovery across all ages?. Prostate Cancer Prostatic Dis (2024). https://doi.org/10.1038/s41391-023-00784-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41391-023-00784-x

Search

Advanced search

Quick links