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Addressing gaps in healthcare provider knowledge regarding germline testing for prostate cancer through development and testing of a virtual genetics board

Prostate Cancer and Prostatic Diseases (2024)Cite this article

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Abstract

Background

Germline testing is important in prostate cancer and evaluation can be complex.

Methods

We instituted a monthly multi-disciplinary virtual genetics tumor board (7/2021-3/2022). Participants and panelists were surveyed on usefulness and acceptability.

Results

101 participants attended a session, and 77 follow-up surveys were completed. Over 90% participants and 100% panelists endorsed usefulness of the case discussions and usability of the technology. The majority felt it provided new information they will use.

Conclusions

A multidisciplinary genetics board was successfully developed to address complexity in prostate cancer genetics. The virtual platform may enhance dissemination of expertise where there are regional gaps.

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References

  1. Loeb S, Giri VN. Clinical implications of germline testing in newly diagnosed prostate cancer. Eur Urol Oncol. 2021;4:1–9.

    Article  PubMed  Google Scholar 

  2. Paller CJ, Antonarakis ES, Beer TM, Borno HT, Carlo MI, George DJ, et al. Germline genetic testing in advanced prostate cancer; practices and barriers: survey results from the germline genetics working group of the prostate cancer clinical trials consortium. Clin Genitourin Cancer. 2019;17:275–82.e271.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Pillay B, Wootten AC, Crowe H, Corcoran N, Tran B, Bowden P, et al. The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: a systematic review of the literature. Cancer Treat Rev. 2016;42:56–72.

    Article  PubMed  Google Scholar 

  4. Hijazi MA, Prebay ZJ, Johnson A, Wilder S, Patel A, Mehra R, et al. Utilization of a virtual tumor board for the care of patients with renal masses: experience from a quality improvement collaborative. Urol Pract. 2023;10:380–8.

    Article  PubMed  Google Scholar 

  5. Valerio MR, Serretta V, Arico D, Fazio I, Altieri V, Baldari S, et al. A prospective observational study on the structuring process and implementation of a large regional, inter-hospital, virtual multidisciplinary tumor board on prostate cancer. Anticancer Res. 2023;43:501–8.

    Article  PubMed  Google Scholar 

  6. Loeb S, Byrne N, Walter D, Makarov DV, Wise DR, Becker D, et al. Knowledge and practice regarding prostate cancer germline testing among urologists: Gaps to address for optimal implementation. Cancer Treat Res Commun. 2020;25:100212.

    Article  PubMed  Google Scholar 

  7. Giri VN, Walker A, Gross L, Trabulsi EJ, Lallas CD, Kelly WK, et al. Helix: a digital tool to address provider needs for prostate cancer genetic testing in clinical practice. Clin Genitourin Cancer. 2022;20:e104–13.

    Article  PubMed  Google Scholar 

  8. Loeb S, Sanchez Nolasco T, Siu K, Byrne N, Giri VN. Usefulness of podcasts to provide public education on prostate cancer genetics. Prostate Cancer Prostatic Dis. 2023;26:772–7.

    Article  PubMed  Google Scholar 

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Funding

Funding

The ENGAGEMENT study was supported by the Department of Defense (080-27000-X17501).

Author information

Authors and Affiliations

  1. Department of Urology and Population Health, New York University and Manhattan Veterans Affairs, New York, NY, USA

    Stacy Loeb & Adrian Rivera

  2. Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA

    Heather H. Cheng

  3. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MA, USA

    Channing J. Paller

  4. Department of Radiation Oncology, University of Washington, Seattle, WA, USA

    Emily Weg

  5. Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA

    Jennifer Johnson

  6. Yale School of Medicine and Yale Cancer Center, New Haven, CT, USA

    Laura Gross & Veda N. Giri

  7. Division of Biostatistics and Bioinformatics, Sidney Kimmel Medical Colllege, Thomas Jefferson University, Philadelphia, PA, USA

    Scott W. Keith

  8. MD Anderson Cancer Center at Cooper University Health Care, Camden, NJ, USA

    Jessica Russo

  9. Hematology/Oncology, Biological Sciences Division, University of Chicago, Chicago, IL, USA

    Feighanne Hathaway

Authors
  1. Stacy Loeb
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  2. Heather H. Cheng
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  3. Channing J. Paller
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  4. Emily Weg
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  5. Jennifer Johnson
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  6. Laura Gross
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  7. Scott W. Keith
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  8. Jessica Russo
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  9. Feighanne Hathaway
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  10. Adrian Rivera
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  11. Veda N. Giri
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Contributions

Conceptualization SL, HHC, CP, LG, VNG, Methodology SL, LG, SWK, AR, VNG, Formal Analysis AR, Investigation All authors, Data curation LG, Writing original draft SL, Writing review and editing All authors, Supervision VNG, Funding acquision SL, VNG.

Corresponding author

Correspondence to Stacy Loeb.

Ethics declarations

Competing interests

SL reports prior equity in Gilead, unrelated to this publication. HHC reports research funding to institution from Astellas, Clovis Oncology, Color Foundation, Janssen, Medivation, Promontory Therapeutics, Sanofi; Consultant to AstraZeneca; Royalties from UpToDate. CJP reports consulting for Bayer. FH reports educational consultant for AstraZeneca. The remaining authors report no relevant COI.

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Loeb, S., Cheng, H.H., Paller, C.J. et al. Addressing gaps in healthcare provider knowledge regarding germline testing for prostate cancer through development and testing of a virtual genetics board. Prostate Cancer Prostatic Dis (2024). https://doi.org/10.1038/s41391-023-00778-9

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  • DOI: https://doi.org/10.1038/s41391-023-00778-9

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