Abstract
Sociodemographic and lifestyle factors may play a role in determining whether patients with clinically localized prostate cancer (PC) are managed with active surveillance (AS), radical prostatectomy (RP), or radiation therapy (RT); however, these relationships have not been well examined. In a cross-sectional study conducted within an equal access healthcare system, multivariable adjusted regression analysis revealed that living with a spouse or partner was associated with a 65% lower chance of being managed by RT (Pā=ā0.001) and 57% lower risk of being managed by AS (Pā=ā0.042) compared with RP. No other sociodemographic or lifestyle factors were independently associated with treatment modality.
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References
Yap ML, OāConnell DL, Goldsbury DE, Weber MF, Smith DP, Barton MB. Patterns of care for men with prostate cancer: the 45 and Up Study. Med J Aust. 2021;214:271ā8.
Chierigo F, Wenzel M, Wurnschimmel C, Simone Flammia R, Horlemann B, Tian Z, et al. Survival after radical prostatectomy versus radiation therapy in high-risk and very high-risk prostate cancer. J Urol. 2022;207:375ā84.
Antonelli A, Palumbo C, Noale M, Artibani W, Bassi P, Bertoni F, et al. Overview of potential determinants of radical prostatectomy versus radiation therapy in management of clinically localized prostate cancer: results from an Italian, prospective, observational study (the Pros-IT CNR study). Minerva Urol Nefrol. 2020;72:595ā604.
Denberg TD, Beaty BL, Kim FJ, Steiner JF. Marriage and ethnicity predict treatment in localized prostate carcinoma. Cancer. 2005;103:1819ā25.
Schymura MJ, Kahn AR, German RR, Hsieh MC, Cress RD, Finch JL, et al. Factors associated with initial treatment and survival for clinically localized prostate cancer: results from the CDC-NPCR Patterns of Care Study (PoC1). BMC Cancer. 2010;10:152.
Yan Y, Carvalhal GF, Catalona WJ, Young JD. Primary treatment choices for men with clinically localized prostate carcinoma detected by screening. Cancer. 2000;88:1122ā30.
Sayyid RK, Klotz L, Benton JZ, Lodh A, Lambert JH, Woodruff P, et al. Influence of sociodemographic factors on definitive intervention among low-risk active surveillance patients. Urology. 2021;155:117ā23.
Charles C, Gafni A, Whelan T. Decision-making in the physician-patient encounter: revisiting the shared treatment decision-making model. Soc Sci Med. 1999;49:651ā61.
OāRourke ME. Narrowing the options: the process of deciding on prostate cancer treatment. Cancer Invest. 1999;17:349ā59.
Chen ZH, Yang KB, Zhang YZ, Wu CF, Wen DW, Lv JW, et al. Assessment of modifiable factors for the association of marital status with cancer-specific survival. JAMA Netw Open. 2021;4:e2111813.
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EMA: Conceptualization, writingāoriginal draft and writingāreview and editing. LG: Formal analysis, writingāreview, and editing. TO: Formal analysis, writingāreview, and editing. AMDH: Methodology, data collection, writingāreview, and editing. EW: Methodology, data collection, writingāreview, and editing. CJG: Writingāreview, and editing. DJL: Writingāreview, and editing. TJD: Methodology, writingāreview, and editing. SJF: Conceptualization, methodology, data collection, supervision, writingāreview, and editing. ZSZ: Conceptualization, methodology, supervision, writingāoriginal draft, and writingāreview and editing. IC: Conceptualization, methodology, supervision, writingāoriginal draft, and writingāreview and editing.
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The authors have no conflicts of interest related to this work. ZSZ was on the external advisory board for the Scripps Proton Therapy Center and has consulted for EMD Serono. ZSZās spouse does legal work for Johnson and Johnson and Allergan through her law firm. All other authors have no disclosures.
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Anderson, E.M., Gu, L., Oyekunle, T. et al. Lifestyle and sociodemographic factors associated with treatment choice of clinically localized prostate cancer in an equal access healthcare system. Prostate Cancer Prostatic Dis 25, 593ā595 (2022). https://doi.org/10.1038/s41391-022-00551-4
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DOI: https://doi.org/10.1038/s41391-022-00551-4