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Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome

Pediatric Research (2024)Cite this article

Impact

  • This study reveals the effects of maternal gestational diabetes mellitus (GDM) on the transcriptome of CD71+ erythroid cells (CECs) in cord blood.

  • It highlights the role of CECs in immunosuppressive function and identifies potential mechanisms linking GDM to adverse outcomes in offspring.

  • This understanding might lead to improved strategies for managing and preventing adverse outcomes in infants born to mothers with GDM.

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Fig. 1: Clustering of erythrocytes showing an impaired immunomodulatory function of CECs affected by maternal GDM.

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Data availability

The raw scRNA-seq datasets in the FASTQ format with filtered barcode matrix have been uploaded to the Gene Expression Omnibus (GEO) database: GSE212309. Other data generated and/or analyzed in this study are available on reasonable request from the corresponding author.

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Funding

Funding

This study was supported by the National Natural Science Foundation of China (grant no. 82070812), the Science and Technology Innovation Program of Hunan Province(2020RC4044).

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Authors and Affiliations

  1. National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China

    Min Yin, Yan Zhang, Xinyu Li & Xia Li

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  1. Min Yin
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  2. Yan Zhang
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  3. Xinyu Li
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  4. Xia Li
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Contributions

All authors contributed to the manuscript preparation. M.Y. and X.L. codesigned the topics and research framework. M.Y., Y.Z. and X.Y.L contributed to the data analysis. M.Y. wrote the manuscript. X.L. revised the manuscript. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Xia Li.

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The authors declare no competing interests.

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Yin, M., Zhang, Y., Li, X. et al. Unveiling the impact of maternal gestational diabetes mellitus on cord blood CD71+ erythroid cell transcriptome. Pediatr Res (2024). https://doi.org/10.1038/s41390-024-03139-x

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  • DOI: https://doi.org/10.1038/s41390-024-03139-x

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