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  1. Monaghan, M. et al. Pediatric Lyme disease: systematic assessment of post-treatment symptoms and quality of life. Pediatr. Res. (2023).

  2. Salazar, J. C., Gerber, M. A. & Goff, C. W. Long-term outcome of Lyme disease in children given early treatment. J. Pediatr. 122, 591–593 (1993).

    Article  CAS  PubMed  Google Scholar 

  3. Rose, C. D. et al. Pediatric Lyme arthritis: clinical spectrum and outcome. J. Pediatr. Orthop. 14, 238–241 (1994).

    Article  CAS  PubMed  Google Scholar 

  4. Gerber, M. A., Shapiro, E. D., Burke, G. S., Parcells, V. J. & Bell, G. L. Lyme disease in children in southeastern Connecticut. Pediatric Lyme Disease Study Group. N. Engl. J. Med. 335, 1270–1274 (1996).

    Article  CAS  PubMed  Google Scholar 

  5. Gerber, M. A., Zemel, L. S. & Shapiro, E. D. Lyme arthritis in children: clinical epidemiology and long-term outcomes. Pediatrics 102, 905–908 (1998).

    Article  CAS  PubMed  Google Scholar 

  6. Eppes, S. C. & Childs, J. A. Comparative study of cefuroxime axetil versus amoxicillin in children with early Lyme disease. Pediatrics 109, 1173–1177 (2002).

    Article  PubMed  Google Scholar 

  7. Thorstrand, C., Belfrage, E., Bennet, R., Malmborg, P. & Eriksson, M. Successful treatment of neuroborreliosis with ten day regimens. Pediatr. Infect. Dis. J. 21, 1142–1145 (2002).

    Article  PubMed  Google Scholar 

  8. van Samkar, A. et al. Clinical characteristics of Lyme neuroborreliosis in Dutch children and adults. Eur. J. Pediatr. 182, 1183–1189 (2023).

    Article  PubMed  Google Scholar 

  9. Berglund, J., Stjernberg, L., Ornstein, K., Tykesson-Joelsson, K. & Walter, H. 5-y Follow-up study of patients with neuroborreliosis. Scand. J. Infect. Dis. 34, 421–425 (2002).

    Article  PubMed  Google Scholar 

  10. Skogman, B. H. et al. Long-term clinical outcome after Lyme neuroborreliosis in childhood. Pediatrics 130, 262–269 (2012).

    Article  PubMed  Google Scholar 

  11. Fallon, B. A., Madsen, T., Erlangsen, A. & Benros, M. E. Lyme borreliosis and associations with mental disorders and suicidal behavior: a nationwide Danish Cohort Study. Am. J. Psychiatry 178, 921–931 (2021).

    Article  PubMed  Google Scholar 

  12. Haahr, R. et al. Risk of neurological disorders in patients with European Lyme neuroborreliosis: a nationwide, population-based cohort study. Clin. Infect. Dis. 71, 1511–1516 (2020).

    Article  PubMed  Google Scholar 

  13. Adams, W. V., Rose, C. D., Eppes, S. C. & Klein, J. D. Long-term cognitive effects of Lyme disease in children. Appl. Neuropsychol. 6, 39–45 (1999).

    Article  CAS  PubMed  Google Scholar 

  14. Vazquez, M., Sparrow, S. S. & Shapiro, E. D. Long-term neuropsychologic and health outcomes of children with facial nerve palsy attributable to Lyme disease. Pediatrics 112, e93–e97 (2003).

    Article  PubMed  Google Scholar 

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This work was supported by the Clinical and Translational Science Institute at Children’s National (CTSI-CN) [Grant numbers UL1TR001876-05 and UL1TR001876-02S1] and the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (to A.M.).

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All authors drafted the response, revised it critically for important intellectual content, and provided final approval of the submitted manuscript.

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Correspondence to Roberta L. DeBiasi.

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Competing interests

M.M. is currently employed by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. All data for this manuscript were collected prior to her employment at the National Institutes of Health. A.M. is employed by the National Institute of Allergy and Infectious Diseases, National Institutes of Health; A.M. has a patent (US 8,926,989) and serves as an unpaid scientific advisor to the Global Lyme Alliance and the American Lyme Disease Foundation. The other authors declare no competing interests.

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Monaghan, M., Norman, S., Gierdalski, M. et al. Reply to Correspondence. Pediatr Res (2023).

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