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Insights Image for “Treatment of severe Kaposiform Lymphangiomatosis positive for NRAS mutation by MEK-inhibition”

Pediatric Research volume 94, page 2117 (2023)Cite this article

Major pathways involved in KLA pathogenesis RAS-MAPK and PIK3-AKT-mTOR pathways are activated by the gain-of function NRAS mutation (p.Q61R) while CBL is an upstream protein involved in its regulation. Panel a- Lymphatic system. Panel b- Schematic of Lymphatic endothelial cell.

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Author notes

  1. These authors contributed equally: Guy Chowers, Gadi Abebe-Campino, Hana Golan.

Authors and Affiliations

  1. Pediatrics B, Edmond and Lili Safra Children’s Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Guy Chowers, Asaf Vivante & Adi Dagan

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Gadi Abebe-Campino, Hana Golan, Asaf Vivante, Shoshana Greenberger, Galia Barkai & Adi Dagan

  3. Pediatric Hematology Oncology division, Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Gadi Abebe-Campino & Hana Golan

  4. Pediatric Nephrology Unit, Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Asaf Vivante

  5. Pediatric Dermatology Unit, Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Shoshana Greenberger

  6. Pediatric Imaging Unit, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Michalle Soudack

  7. Pediatric Infectious Diseases Unit, Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Galia Barkai

  8. Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Ilana Fox-Fisher

  9. Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Dong Li, Michael March, Mark R. Battig & Hakon Hakonarson

  10. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Hakon Hakonarson & Yoav Dori

  11. Divisions of Human Genetics and Pulmonary Medicine, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Hakon Hakonarson

  12. Comprehensive Vascular Anomalies Program, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA

    Denise Adams

  13. Jill and Mark Fishman Center for Lymphatic Disorders, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Yoav Dori

  14. Pediatric Pulmonary Unit and the National Center for Cystic Fibrosis, Edmond and Lili Safra Children’s Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat-Gan, Israel

    Adi Dagan

Authors
  1. Guy Chowers
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  2. Gadi Abebe-Campino
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  3. Hana Golan
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  4. Asaf Vivante
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  5. Shoshana Greenberger
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  6. Michalle Soudack
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  7. Galia Barkai
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  8. Ilana Fox-Fisher
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  9. Dong Li
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  10. Michael March
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  11. Mark R. Battig
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  12. Hakon Hakonarson
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  13. Denise Adams
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  14. Yoav Dori
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  15. Adi Dagan
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Corresponding author

Correspondence to Adi Dagan.

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Cite this article

Chowers, G., Abebe-Campino, G., Golan, H. et al. Insights Image for “Treatment of severe Kaposiform Lymphangiomatosis positive for NRAS mutation by MEK-inhibition”. Pediatr Res 94, 2117 (2023). https://doi.org/10.1038/s41390-023-02755-3

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  • DOI: https://doi.org/10.1038/s41390-023-02755-3

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