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Kirpalani, H. et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J. Pediatr. 149, 301–307 (2006).
Guillen, U. et al. International survey of transfusion practices for extremely premature infants. Semin. Perinatol. 36, 244–247 (2012).
Keir, A. K., Yang, J., Harrison, A., Pelausa, E. & Shah, P. S., Canadian Neonatal Network. Temporal changes in blood product usage in preterm neonates born at less than 30 weeks’ gestation in Canada. Transfusion 55, 1340–1346 (2015).
Ringer, S. A., Richardson, D. K., Sacher, R. A., Keszler, M. & Churchill, W. H. Variations in transfusion practice in neonatal intensive care. Pediatrics 101, 194–200 (1998).
Vu, P. T. et al. Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial. Pediatr Res. 11, 1–8 (2021). https://doi.org/10.1038/s41390-020-01273-w.
Juul, S. E. et al. A randomized trial of erythropoietin for neuroprotection in preterm infants. N. Engl. J. Med. 382, 233–243 (2020).
Bell, E. F. et al. Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 115, 1685–1691 (2005).
Westkamp, E. et al. Blood transfusion in anemic infants with apnea of prematurity. Biol. Neonate 82, 228–232 (2002).
Valieva, O. A., Strandjord, T. P., Mayock, D. E. & Juul, S. E. Effects of transfusions in extremely low birth weight infants: a retrospective study. J. Pediatr. 155, 331–337 e1 (2009).
Teiserskas, J., Bartasiene, R. & Tameliene, R. Associations between red blood cell transfusions and necrotizing enterocolitis in very low birth weight infants: ten-year data of a tertiary neonatal unit. Medicine 55, 1 (2019).
Blau, J. et al. Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J. Pediatr. 158, 403–409 (2011).
Rai, S. E., Sidhu, A. K. & Krishnan, R. J. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. J. Perinat. Med. 46, 665–676 (2018).
Christensen, R. D. et al. Is “transfusion-associated necrotizing enterocolitis” an authentic pathogenic entity? Transfusion 50, 1106–1112 (2010).
Bajaj, M., Lulic-Botica, M., Hanson, A. & Natarajan, G. Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants. J. Perinatol. 39, 540–546 (2019).
Slidsborg, C. et al. Neonatal risk factors for treatment-demanding retinopathy of prematurity: a Danish National Study. Ophthalmology 123, 796–803 (2016).
Baer, V. L., Lambert, D. K., Henry, E., Snow, G. L. & Christensen, R. D. Red blood cell transfusion of preterm neonates with a grade 1 intraventricular hemorrhage is associated with extension to a grade 3 or 4 hemorrhage. Transfusion 51, 1933–1939 (2011).
Rashid, N., Al-Sufayan, F., Seshia, M. M. & Baier, R. J. Post transfusion lung injury in the neonatal population. J. Perinatol. 33, 292–296 (2013).
McCoy, T. E. et al. Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol. 17, 347–367 (2011).
Nopoulos, P. C. et al. Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. Arch. Pediatr. Adolesc. Med. 165, 443–450 (2011).
Ohlsson, A. & Aher, S. M. Early erythropoiesis-stimulating agents in preterm or low birth weight infants. Cochrane Database Syst. Rev. 2, CD004863 (2020).
Juul, S. E. et al. Effect of high-dose erythropoietin on blood transfusions in extremely low gestational age neonates: post hoc analysis of a randomized clinical trial. JAMA Pediatr. 174, 933–943 (2020).
Aher, S. M. & Ohlsson, A. Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst. Rev. 4, CD004868 (2014).
Fogarty, M. et al. Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis. Am. J. Obstet. Gynecol. 218, 1–18 (2018).
Mahieu, L. et al. Implementation of a multi-parameter point-of-care-blood test analyzer reduces central laboratory testing and need for blood transfusions in very low birth weight infants. Clin. Chim. Acta 413, 325–330 (2012).
Jin, H. X., Wang, R. S., Chen, S. J., Wang, A. P. & Liu, X. Y. Early and late Iron supplementation for low birth weight infants: a meta-analysis. Ital. J. Pediatr. 41, 16 (2015).
Franz, A. R. et al. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial. JAMA 324, 560–570 (2020).
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Piersigilli, F. Transfusions and neurodevelopmental outcomes in extremely low gestation neonates: to transfuse or not to transfuse, that is the question…. Pediatr Res (2021). https://doi.org/10.1038/s41390-021-01470-1