Review Article | Published:

Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review

Pediatric Researchvolume 85pages134145 (2019) | Download Citation

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Abstract

Background

Maternal depression complicates a large proportion of pregnancies. Current evidence shows numerous harmful effects on the offspring. Reviews, which include depression, concluded that stress has harmful effects on the offspring’s outcomes neuro-cognitive development, temperament traits, and mental disorders.

Objective

This mini review of recent studies, sought to narrow the scope of exposure and identify studies specifically assessing prenatal depression and offspring neuropsychiatric outcomes.

Study eligibility criteria

The review included longitudinal, cohort, cross-sectional, clinical, quasi-experimental, epidemiological, or intervention study designs published in English from 2014 to 2018.

Participants

Study populations included mother-child dyads, mother-father-child triads, mother-alternative caregiver-child triads, and family studies utilizing sibling comparisons.

Methods

We searched PubMED and Web of Science. Study inclusion and data extraction were based on standardized templates. The quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS).

Results

Thirteen studies examining neuropsychiatric outcomes were included. We judged the evidence to be moderate to high quality.

Conclusions

Our review supports that maternal prenatal depression is associated with neuropsychiatric adversities in children.

Implications

Future investigations should unravel the biological underpinnings and target timely interventions as early in pregnancy as possible to prevent offspring neuropsychiatric harms.

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Acknowledgements

Funding for this review comes from an Academy of Finland Program Grant, European Commission Horizon 2020 Award SC1-2016-RTD-733280 for RECAP, European Commission Dynamics of Inequality Across the Life-course: structures and processes (DIAL) No. 724363 for PremLife, and the Signe and Ane Gyllenberg Foundation.

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Affiliations

  1. Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland

    • Rachel Robinson
    • , Marius Lahti-Pulkkinen
    • , Kati Heinonen
    •  & Katri Räikkönen
  2. University/British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

    • Rebecca M. Reynolds

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The authors declare no competing interests.

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Correspondence to Rachel Robinson.

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https://doi.org/10.1038/s41390-018-0173-y