Abstract
Gliomas are highly malignant tumors accounting for the majority of brain neoplasms. They are characterized by nuclear atypia, high mitotic rate and cellular polymorphism that often contributes to aggressiveness and resistance to standard therapy. They often associate with challenging treatment approaches and poor outcomes. New treatment strategies or regimens to improve the efficacy of glioma treatment require a deeper understanding of glioma occurrence and development as well as elucidation of their molecular biological characteristics. Recent studies have revealed RNA modifications as a key regulatory mechanism involved in tumorigenesis, tumor progression, immune regulation, and response to therapy. The present review discusses research advances on several RNA modifications involved in glioma progression and tumor microenvironment (TME) immunoregulation as well as in the development of adaptive drug resistance, summarizing current progress on major RNA modification targeting strategies.
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CP and AGP conceived and defined the scope of the review and agreed to be accountable for all aspects of the work. MM and CP conducted the primary literature search and analysis and drafted the manuscript. AGP refined the literature search and confirmed all cited articles, revised the manuscript, and agreed to be accountable for all aspects of the work. All authors, including MM, ANG, KAP, CP, and AGP, reviewed the results, provided critical feedback and comments, and approved the final version of the manuscript.
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Piperi, C., Markouli, M., Gargalionis, A.N. et al. Deciphering glioma epitranscriptome: focus on RNA modifications. Oncogene 42, 2197–2206 (2023). https://doi.org/10.1038/s41388-023-02746-y
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DOI: https://doi.org/10.1038/s41388-023-02746-y
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