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Heat-shock proteins: chaperoning DNA repair

Oncogene volume 39, pages 516–529 (2020)Cite this article

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Abstract

Cells are repeatedly exposed to environmental or endogenous stresses that can alter normal cell behavior and increase cell vulnerability. In order to ensure tissue integrity and function, cells cope with cellular injuries by adapting their metabolism, protecting essential intracellular constituents, inhibiting cell death signaling pathways and activating those devoted to damage repair. The molecular chaperones of the heat-shock protein (HSP) family are critical effectors of this adaptive response. They protect intracellular proteins from misfolding or aggregation, inhibit cell death signaling cascades and preserve the intracellular signaling pathways that are essential for cell survival. Most HSPs are rapidly overexpressed in response to cellular injuries including genotoxic stress. DNA damage can dramatically alter cell behavior and contribute to a number of diseases including developmental defects, neurodegenerative disorders, and cancer. Thus, the ability of cells to repair DNA damage is essential for preserving cell integrity. DNA damage activates a coordinated response that includes detecting DNA lesions before their transmission to daughter cells, blocking cell cycle progression and DNA replication and repairing the damage. Although the role of HSPs in proteins homeostasis and cell death, especially apoptosis has been widely reported, much less is known about their function in DNA repair. This review aims to present the role of HSPs in DNA repair signaling pathways.

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Acknowledgements

Our work was supported by grants from the Institut National du Cancer, Ligue Nationale Contre le Cancer, the Conseil Regional de Bourgogne, a French Government grants managed by the French National Research Agency under the program“Investissements d’Avenir” with reference ANR-11-LABX-0021 (LabEX LipSTIC) and ANR-15-IDEX-0003 (I-SITE-UBFC). We thank the “Fondation de France” (SC) and the European Union program FEDER.

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Authors and Affiliations

  1. INSERM UMR 1231, « Equipe labellisée » Ligue National contre le Cancer » and Laboratoire d’Excellence LipSTIC, Dijon, France

    Laurence Dubrez, Sébastien Causse, Natalia Borges Bonan, Baptiste Dumétier & Carmen Garrido

  2. Université de Bourgogne- Franche Comté, Dijon, France

    Laurence Dubrez, Sébastien Causse, Natalia Borges Bonan, Baptiste Dumétier & Carmen Garrido

  3. Anticancer Center Georges François Leclerc-Unicancer, Dijon, France

    Carmen Garrido

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  1. Laurence Dubrez
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Dubrez, L., Causse, S., Borges Bonan, N. et al. Heat-shock proteins: chaperoning DNA repair. Oncogene 39, 516–529 (2020). https://doi.org/10.1038/s41388-019-1016-y

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