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Reimherr FW, Amsterdam JD, Quitkin FM, Rosenbaum JF, Fava M, Zajecka J, et al. Optimal length of continuation therapy in depression: a prospective assessment during long-term fluoxetine treatment. Am J Psychiatry. 1998;155:1247–53.
Kato M, Hori H, Inoue T, Iga J, Iwata M, Inagaki T, et al. Discontinuation of antidepressants after remission with antidepressant medication in major depressive disorder: a systematic review and meta-analysis. Mol Psychiatry. 2021;26:118–33.
Kishi T, Sakuma K, Hatano M, Okuya M, Matsuda Y, Kato M et al. Relapse and its modifiers in major depressive disorder after antidepressant discontinuation: meta-analysis and meta-regression. Mol Psychiatry. 2022;28:974–76.
Wilson K, Mottram P, Ashworth L, Abou-Saleh M. Older community residents with depression: long-term treatment with sertraline. Randomised, double-blind, placebo-controlled study. Br J Psychiatry. 2003;182:492–7.
Keller M, Kocsis J, Thase M, Gelenberg A, Rush A, Koran L, et al. Maintenance phase efficacy of sertraline for chronic depression: a randomized controlled trial. JAMA. 1998;280:1665–72.
Hochstrasser B, Isaksen P, Koponen H, Lauritzen L, Mahnert F, Rouillon F, et al. Prophylactic effect of citalopram in unipolar, recurrent depression: placebo-controlled study of maintenance therapy. Br J Psychiatry. 2001;178:304–10.
Dalery J, Dagens-Lafont V, Bodinat C. Efficacy of tianeptine vs placebo in the long-term treatment (16.5 months) of unipolar major recurrent depression. Hum Psychopharmacol. 2001;16:S39–s47.
Goodwin G, Boyer P, Emsley R, Rouillon F, Bodinat C. Is it time to shift to better characterization of patients in trials assessing novel antidepressants? An example of two relapse prevention studies with agomelatine. Int Clin Psychopharmacol. 2013;28:20–28.
Kocsis J, Thase M, Trivedi M, Shelton R, Kornstein S, Nemeroff C, et al. Prevention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT Study. J Clin Psychiat. 2007;68:1014–23.
McGrath P, Stewart J, Quitkin F, Chen Y, Alpert J, Nierenberg A, et al. Predictors of relapse in a prospective study of fluoxetine treatment of major depression. Am J Psychiatry. 2006;163:1542–8.
Montgomery SA, Dunbar G. Paroxetine is better than placebo in relapse prevention and the prophylaxis of recurrent depression. Int Clin Psychopharmacol. 1993;8:189–95.
Aoki Y, Takaesu Y, Baba H, Iga JI, Hori H, Inoue T, et al. Development and acceptability of a decision aid for major depressive disorder considering discontinuation of antidepressant treatment after remission. Neuropsychopharmacol Rep. 2022;42:306–14.
MK has received grant funding from the Ministry of Health, Labor and Welfare of Japan, the Japan Society for the Promotion of Science, SENSHIN Medical Research Foundation, and Japan Research Foundation for Clinical Pharmacology, and speaker’s honoraria from Sumitomo Dainippon Pharma, Otsuka, Meiji-Seika Pharma, Eli Lilly, MSD K.K., GlaxoSmithKline, Pfizer, Janssen Pharmaceutical, Shionogi, Mitsubishi Tanabe Pharma, Takeda Pharmaceutical, Lundbeck, and Ono Pharmaceutical. AT received lecture fees from Sumitomo Dainippon Pharma, Eisai, Janssen Pharmaceutical, Meiji-Seika Pharma, Mitsubishi Tanabe Pharma, Otsuka and Takeda Pharmaceutical. HH received speaker honoraria from Eisai, Eli Lilly, Janssen Pharmaceutical, Meiji-Seika Pharma, Otsuka, Pfizer, Sumitomo Dainippon Pharma, and Takeda Pharmaceutical.
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Kato, M., Hori, H. & Tajika, A. Appropriate duration of antidepressant medications for prevention of depressive relapse and the impact of life stage. Mol Psychiatry (2023). https://doi.org/10.1038/s41380-023-02023-0