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Aberrant qNSC activity mediates decreased active neurogenesis in the Shank3 deficient Autism development

Molecular Psychiatry volume 27, page 2637 (2022)Cite this article

Fig. 1 Representative imaging of active neural stem cells (aNSCs) with specific markers from SHANK3-deficient human iPSC derived NSCs. Immunostaining of GFAP+SOX2+EGFR+ aNSCs (upper panels) and KI67+ proliferating NSCs (lower panels) derived from control or SHANK3-deficient human qNSCs. Scale bar = 20 µm. For more information, please refer to the article by Kim et al. in this issue.

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Author notes

  1. These authors contributed equally: Hongwon Kim, Byounggook Cho, Hanseul Park.

Authors and Affiliations

  1. Laboratory of Stem Cells & Cell Reprogramming, Department of Chemistry and Biomedical Engineering, Dongguk University, Seoul, 04620, Republic of Korea

    Hongwon Kim, Byounggook Cho, Hanseul Park, Junyeop Kim, Siyoung Kim, Jaein Shin & Jongpil Kim

  2. Department of Biomedical Sciences, School of Veterinary Medicine and Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Christopher J. Lengner

  3. Biotech Research and Innovation Centre (BRIC) and Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen, Copenhagen, Denmark

    Kyoung-Jae Won

Authors
  1. Hongwon Kim
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  2. Byounggook Cho
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  3. Hanseul Park
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  4. Junyeop Kim
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  5. Siyoung Kim
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  7. Christopher J. Lengner
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  8. Kyoung-Jae Won
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  9. Jongpil Kim
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Correspondence to Kyoung-Jae Won or Jongpil Kim.

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Kim, H., Cho, B., Park, H. et al. Aberrant qNSC activity mediates decreased active neurogenesis in the Shank3 deficient Autism development. Mol Psychiatry 27, 2637 (2022). https://doi.org/10.1038/s41380-022-01607-6

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