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Reply to Brune M and Theiss C: Remaining questions in the relationship between T. gondii infection and major mental illness

Molecular Psychiatry volume 25, pages 4–5 (2020)Cite this article

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References

  1. Brune M, Theiss C. Commentary on: “Host-parasite interaction associated with major mental illness”. Why we need integrative explanations based on evolutionary theory. Mol Psychiatry. 2019. https://doi.org/10.1038/s41380-019-0541-y.

  2. Kano SI, Hodgkinson CA, Jones-Brando L, Eastwood S, Ishizuka K, Niwa M et al. Host-parasite interaction associated with major mental illness. Mol Psychiatry. 2018. https://doi.org/10.1038/s41380-018-0217-z

  3. Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K, Erwin JM, et al. The von Economo neurons in the frontoinsular and anterior cingulate cortex. Ann N Y Acad Sci. 2011;1225:59–71.

    Article  Google Scholar 

  4. Kim EJ, Sidhu M, Gaus SE, Huang EJ, Hof PR, Miller BL, et al. Selective frontoinsular von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia. Cereb Cortex. 2012;22:251–9.

    Article  Google Scholar 

  5. Santos M, Uppal N, Butti C, Wicinski B, Schmeidler J, Giannakopoulos P, et al. Von Economo neurons in autism: a stereologic study of the frontoinsular cortex in children. Brain Res. 2011;1380:206–17.

    Article  CAS  Google Scholar 

  6. Brune M, Schobel A, Karau R, Faustmann PM, Dermietzel R, Juckel G, et al. Neuroanatomical correlates of suicide in psychosis: the possible role of von Economo neurons. PLoS One. 2011;6:e20936.

    Article  Google Scholar 

  7. Allman JM, Tetreault NA, Hakeem AY, Manaye KF, Semendeferi K, Erwin JM, et al. The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain Struct Funct. 2010;214:495–517.

    Article  Google Scholar 

  8. Xiao J, Prandovszky E, Kannan G, Pletnikov MV, Dickerson F, Severance EG, et al. Toxoplasma gondii: biological parameters of the connection to schizophrenia. Schizophr Bull. 2018;44:983–92.

    Article  Google Scholar 

  9. Network, Pathway Analysis Subgroup of Psychiatric Genomics C. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci. 2015;18:199–209.

    Article  Google Scholar 

  10. Burgdorf KS, Trabjerg BB, Pedersen MG, Nissen J, Banasik K, Pedersen OB, et al. Large-scale study of toxoplasma and cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain Behav Immun. 2019;79:152–8.

    Article  Google Scholar 

  11. Behnke MS, Dubey JP, Sibley LD. Genetic mapping of pathogenesis determinants in Toxoplasma gondii. Annu Rev Microbiol. 2016;70:63–81.

    Article  CAS  Google Scholar 

  12. Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet. 2004;363:1965–76.

    Article  CAS  Google Scholar 

  13. Brown AS, Schaefer CA, Quesenberry CP Jr., Liu L, Babulas VP, Susser ES. Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry. 2005;162:767–73.

    Article  Google Scholar 

  14. Rosshart SP, Herz J, Vassallo BG, Hunter A, Wall MK, Badger JH, et al. Laboratory mice born to wild mice have natural microbiota and model human immune responses. Science. 2019;365:6452.

    Article  Google Scholar 

  15. Gamo NJ, Sawa A. Human stem cells and surrogate tissues for basic and translational study of mental disorders. Biol Psychiatry. 2014;75:918–9.

    Article  Google Scholar 

  16. Di Lullo E, Kriegstein AR. The use of brain organoids to investigate neural development and disease. Nat Rev Neurosci. 2017;18:573–84.

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA

    Shin-ichi Kano

  2. Departments of Psychiatry, Neuroscience, Biomedical Engineering, and Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA

    Akira Sawa

  3. Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21287, USA

    Akira Sawa

Authors
  1. Shin-ichi Kano
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  2. Akira Sawa
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Correspondence to Shin-ichi Kano or Akira Sawa.

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Kano, Si., Sawa, A. Reply to Brune M and Theiss C: Remaining questions in the relationship between T. gondii infection and major mental illness. Mol Psychiatry 25, 4–5 (2020). https://doi.org/10.1038/s41380-019-0556-4

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