Studying treatment resistance in depression using patient derived neurons in vitro

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Stylized artistic images of forebrain neurons derived from iPSCs of antidepressant (SSRI) resistant depressed patients. Neurons from SSRI-resistant patients display differential activity in response to serotonin, downstream of key excitatory serotonergic receptors, highlighting a potential mechanism underlying SSRI-resistance in major depressive disorder (MDD). Images are modified from Figure 2c of Vadodaria et al., on pages 795–807 of this issue

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Correspondence to Fred H. Gage.

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Vadodaria, K.C., Ji, Y., Skime, M. et al. Studying treatment resistance in depression using patient derived neurons in vitro. Mol Psychiatry 24, 775 (2019). https://doi.org/10.1038/s41380-019-0424-2

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