Can electronic health records revive central nervous system clinical trials?

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Correspondence to Roy H. Perlis.

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In the past three years, Roy Perlis has served on advisory boards or provided consulting to Genomind, Psy Therapeutics, RIDVentures, and Takeda. He receives patent royalties from Massachusetts General Hospital. In the past three years, Maurizio Fava reports the following research support: Alkermes, Inc., Johnson & Johnson, Axsome, Acadia Pharmaceuticals, Cerecor, Lundbeck Inc., Neuralstem, Otsuka, Taisho, Marinus Pharmaceuticals, BioHaven, Takeda, Vistagen, Relmada Therapeutics Inc., Stanley Medical Research Institute (SMRI), National Institute of Drug Abuse (NIDA), National Institute of Mental Health (NIMH), and PCORI. Dr. Fava has not done any personal consulting. Any consulting he has done has been on behalf of Massachusetts General Hospital. Dr. Fava has equity holdings in Compellis and PsyBrain Inc. Dr. Fava has patents for Sequential Parallel Comparison Design (SPCD), licensed by MGH to Pharmaceutical Product Development, LLC; a patent application for a combination of Ketamine plus Scopolamine in Major Depressive Disorder (MDD), licensed by MGH to Biohaven; and patents for pharmacogenomics of Depression Treatment with Folate. Dr. McCoy declares that he has no conflict of interest.

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Perlis, R.H., Fava, M. & McCoy, T.H. Can electronic health records revive central nervous system clinical trials?. Mol Psychiatry 24, 1096–1098 (2019). https://doi.org/10.1038/s41380-018-0278-z

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