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References
Clarke TK, Adams MJ, Davies G, Howard DM, Hall LS, Padmanabhan S, et al. Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117). Mol Psychiatry. 2017;22:1376-84.
Aschard H, Vilhjalmsson BJ, Joshi AD, Price AL, Kraft P. Adjusting for heritable covariates can bias effect estimates in genome-wide association studies. Am J Hum Genet. 2015;96:329–39.
Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ. 2014;349:g4164.
Yun KE, Chang Y, Yun SC, Davey Smith G, Ryu S, Cho SI, et al. Alcohol and coronary artery calcification: an investigation using alcohol flushing as an instrumental variable. Int J Epidemiol. 2017;46:950–62.
Dale C, Fatemifar G, Palmer T, White J, Prieto-Merino D, Zabaneh D, et al. Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes and type 2 diabetes: a Mendelian randomization analysis. Circulation. 2017;135:2373–88.
Emdin CA, Khera AV, Natarajan P, Klarin D, Zekavat SM, Hsiao AJ, et al. Genetic association of waist-to-hip ratio with cardiometabolic traits, type 2 diabetes, and coronary heart disease. JAMA. 2017;317:626–34.
Davey Smith G, Paternoster L, Relton C. When will Mendelian randomization become relevant for clinical practice and public health? JAMA. 2017;317:589–91.
Holmes MV, Ala-Korpela M, Davey Smith G. Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol. 2017;14:577–90.
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Holmes, M.V., Davey Smith, G. Problems in interpreting and using GWAS of conditional phenotypes illustrated by 'alcohol GWAS'. Mol Psychiatry 24, 167–168 (2019). https://doi.org/10.1038/s41380-018-0037-1
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DOI: https://doi.org/10.1038/s41380-018-0037-1
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