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STEM CELL BIOLOGY

Lactate—a new player in G-CSF-induced mobilization of hematopoietic stem/progenitor cells

Leukemia volume 37, pages 1757–1761 (2023)Cite this article

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Fig. 1: G-CSF activates neutrophils to increase BM lactate.
Fig. 2: Lactate induces HSPC proliferation and mobilization.

Data availability

All data generated or analysed during this study are included in this published article [and its supplementary information files].

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Acknowledgements

We gratefully acknowledge Tomer Itkin, Ph.D. Weill Cornell Medicine, Department of Medicine Division of Regenerative Medicine Ansary Stem Cell Institute, for critically reviewing the manuscript.

Funding

This work was supported with the aid of a grant from the Canadian Institutes of Health Research (CIHR), the International Development Research Center (IDRC), the Israel Science Foundation (ISF) and the Azrieli Foundation, the Israel Science Foundation (grant No. 2241/21), Weizmann - UK Joint Research Program and the Helen and Martin Kimmel Stem Cell Research Institute.

Author information

Author notes

  1. Eman Khatib-Massalha

    Present address: Wellcome-Medical Research Council (MRC) Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK

  2. These authors contributed equally: Lizeth-Alejandra Ordonez-Moreno, Montaser Haddad.

Authors and Affiliations

  1. Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel

    Lizeth-Alejandra Ordonez-Moreno, Montaser Haddad, Priyasmita Chakrabarti, Eman Khatib-Massalha, Harry Fruchtman, Sigalit Boura-Halfon, Tsvee Lapidot & Orit Kollet

  2. Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel

    Ekaterina Petrovich-Kopitman

Authors
  1. Lizeth-Alejandra Ordonez-Moreno
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Contributions

LAOM and MH reviewed literature, designed, and conducted experiments, analysed results, and wrote the paper. PC, EKH, SBF, EPK, and HF designed and performed experiments, analysed data, and reviewed the manuscript. TL and OK reviewed literature, designed the study concept, guided the research, and wrote the paper.

Corresponding authors

Correspondence to Tsvee Lapidot or Orit Kollet.

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The authors declare no competing interests.

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Ordonez-Moreno, LA., Haddad, M., Chakrabarti, P. et al. Lactate—a new player in G-CSF-induced mobilization of hematopoietic stem/progenitor cells. Leukemia 37, 1757–1761 (2023). https://doi.org/10.1038/s41375-023-01917-w

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